What is a neuromuscular transmission?

In the process of neuromuscular transmission of nerves, they send a signal to muscle fibers to trigger movement and relaxation. This occurs in a place known as a neuromuscular intersection because it forms the connection point between the nervous system and muscle fibers. Neuromuscular transmission disorders can lead to conditions such as partial paralysis and muscle weakness. It is also possible to invoke delays or stop transmission with medicines for activities such as medical procedures. Neurotransmitter reacts with the receptors in the muscle and quickly distracts. In the body it is metabolized for recycling to form more acetylcholine, which provides continuous restoration of the chemical. Fast deliveries and processing allow very fine -grained control, as the nerve can recover quickly and relax more for a permanent muscle enthusiasm has been achieved by the desired goal. These include conscious movements, such as the decision to open the door to the room, as well as unconscious movements such as reflexive reactions. For example, when the knee is hit in the rightThe angle, starts a very fast reflective reaction that ends with a neuromuscular transmission to make the kick of the legs.

One potential disorder involving this process is called myasthenia gravis. This was among the earliest identified and studied neuromuscular disorders and the research of the subject provided important information about how neuromuscular transmission worked. This has become important not only for the treatment of the disease, but also the neuromuscular blocks. In the block, medicines can temporarily stop signal transmission to cause paralysis. Paralytic drugs are used in procedures such as surgery to protect patient safety.

Another useful tool for studies on neuromuscular transmission was the use of knockout studies in mice. In the study Knockout, scientists "set off" the gene and stop the expression. This allows them to find out what the gene is doing and how organisms are adapted when it is no longer functional.Because mouse physiology is similar to physics in humans in terms of neuromuscular transmission, the study of the disease in mice can offer insight into how to effectively treat people. Controlled genetic research with knockout studies can help scientists exactly to determine which genes do what.