What is bone morphogenetic protein?

Bone morphogenetic protein (BMP) is a protein in the family of transformation growth factor (TGF) that can stimulate bone production and cartilage. BMP plays a key role in the formation of embryonic vertebrae, and they also seem to play a key role in signaling the arrangement of another tissue design in the body. A disorder of this system can cause disease. He found that demineralized, dissolved bone segments caused the formation of a new bone when implanted in rabbit cases. Dr. Urist is the one who designed the term bone morphogenetic protein.

There are currently 20 types of bone morphogenetic protein. Originally, only seven and six of them, BMP2-BMP7, were considered as part of the transforming growth factor of beta superstin. BMP1 is what is called metalloprotease, which is the enzyme catalytic process involves metal. Each BMP is placed on a specific chromosome.

bone morphogenetic proteins work with interaction with cellular receptors known as bone morphogenethical protein receptors (BMPR). BMPR then indicates other proteins called SMADS to induce growth. This process contributes to the development of the central nervous system (CNS), heart and cartilage. It also contributes to the development of postnatal bone.

All these proteins play a role in the early formation of the embryo. If the processes and signals they create are impaired, this may affect the development of the skeletal system and the overall pattern of the body. Research has found that 70% of hereditary pulmonary arterial hypertension is caused by mutation in BMPR2. Mutations on chromosomes and related bone morphogenetic protein can also cause abnormalities and skeletal disorders. M.KDs you include a failure of the BMP signaling system.

Members of bone morphogenetic protein were found to be useful in spine therapy. In the United States, BMP-2 and BMP-7 have received food and drug approval (FDA) for use on people because it was found thatE helps with problems where bone structures suffer from neezion and delayed department, two aspects involved in the bone healing process. They can be combined with a bone implant that will be released gradually for weeks to maintain healing. Although expensive, BMP treatment may cost less over time, taking into account the number of corrective operations that may be required from bone injury. It has also been found that the BMP-7 helps to treat damage caused by the kidney glomeruli due to sclerosis.