What Is a Hemostat?

Any drug that can stop bleeding inside and outside the body is called a hemostatic drug. Blood is an important substance in the human body. If bleeding disorders are not stopped in a timely and effective manner, blood loss will be caused, and the body will be weakened, or even life-threatening. Therefore, the application of hemostatic drugs is of great significance.

Hemostatic

(drug)

Any drug that can stop bleeding inside and outside the body is called a hemostatic drug. Blood is an important substance in the human body. If bleeding disorders are not stopped in a timely and effective manner, blood loss will be caused, and the body will be weakened, or even life-threatening. Therefore, the application of hemostatic drugs is of great significance.

Drug Name

Hemostatic

Whether prescription drugs

Non-prescription drugs

Main indications

For various parts of bleeding syndrome

Athletes use with caution

Inadvertent use

Whether to include health insurance

Incorporate

Drug type

Agrimony,

1. Drugs that reduce capillary permeability and fragility can treat bleeding caused by vascular factors, such as Anluoxue, vitamin C, and rutin, etc .; pituitary hormones can act on vascular smooth muscle, making small arteries, small veins, and Capillary blood vessels contract and have a hemostatic effect, especially for hemorrhage of esophageal varices caused by hemoptysis and portal hypertension.

Hemostasis is mainly applicable to bleeding disorders in various parts , such as hemoptysis, hemorrhage , vomiting blood, urine blood, blood in the stool, bleeding, purpura and wound bleeding .

Hemostasis has different medicinal properties, such as medicinal cold, functional hemostasis and hemostasis, suitable for hemorrhagic hemorrhage; medicinal warm, can warm and stop bleeding, suitable for deficient cold hemorrhage; both functions of blood stasis, functional stasis , Suitable for bleeding and blood stasis; medicine convergence, functional convergence to stop bleeding, can be used for bleeding more than a long time.

Main medicine: Agrimony,

There are two contradictory and unified contradictory processes of blood coagulation and anticoagulation in function, and the two complement each other.

Hemostasis can produce hemostatic effects by constricting arterioles and capillaries, or enhancing platelet function, or accelerating and strengthening the blood coagulation process, or inhibiting the clot dissolution process. In the past ten years, the biochemical hemostatic drugs with hemostatic enzymes extracted from snake venom as the main component have been the most popular in clinical application, and have become the mainstream drugs for clinical treatment of bleeding diseases or bleeding states. At present, there are about 20 kinds of hemostatic drugs commonly used in clinical practice in China, which are divided into four categories according to different links acting on the coagulation mechanism.

Procoagulant active drug: It stops bleeding by affecting certain coagulation factors and promoting or restoring the coagulation process. Representative drugs are hemagglutinase, desmopressin,

Precautions for Hemostatic Application

I. Hemostasis According to its medicinal properties, there are differences between cooling blood to stop bleeding, warming to stop bleeding, removing blood stasis and stopping bleeding, and converging to stop bleeding. Clinical application must be treated according to the drug selected according to the drug properties.

2. Hemostasis is a cure for symptoms, and clinical applications need to be accompanied by corresponding drugs such as

Hemostatic drugs include:

1. Hemostasis: Nepeta, windproof (

Clotting

clotting time measurement. The measurement of coagulation time is the main test method to observe whether traditional Chinese medicine has an effect on the mechanism of blood coagulation. If it is found that the traditional Chinese medicine extract has an effect on the clotting time, other experiments can be further considered. Therefore, this method is also a common screening method for screening traditional Chinese medicine. Commonly used methods are the slide method and the test tube method. For example, Hunan Medical College editor "Pharmacological Experiment Guide", the procoagulant effect of calcium chloride. Following the above method, the hemostatic effect test of rhubarb lime water can be performed. When using this method, in addition to comparing the differences in clotting time between normal and medicated animals, several dose groups can be set for testing Chinese medicine, and known Chinese medicines or synthetic medicines can be used as positive control groups. Such as tranexamic acid or tranexamic acid injection, can be used as a control drug, another set.

Prothrombin time measurement. This method is a test method reflecting the presence or absence of obstacles in the exogenous coagulation system.

The effect of traditional Chinese medicine on coagulation factors related to endogenous coagulation system. It is used in studying the hemostatic mechanism of traditional Chinese medicine. This method is also one of the routine screening methods for studying anticoagulants.

Fibrinolysis

Measuring the effect of traditional Chinese medicine on the fibrinolytic process is also an important test method for discovering coagulants and anticoagulants. Because drugs interfere with the fibrinolytic process in the body, coagulation or anticoagulation can occur. Generally, the whole blood or plasma clot is used to measure the fibrinolytic activity, and then the euglobulin dissolution time is measured.

Platelet function

Including platelet adhesion and platelet aggregation experiments. Both have in vitro and in vivo assays. Generally used in vitro assays.

thrombus

This method can reflect the adhesion and aggregation function of platelets in the whole animal blood stream, and its thrombus structure is similar to white thrombus in arteries. The formation of this platelet thrombus is not only affected by drugs, but also with blood flow velocity. Platelet count. When the platelet adhesion and aggregation function is inhibited by the drug, the weight of the thrombus is light, so the platelet adhesion and aggregation function can be determined from the weight of the thrombus. This method can be used to study the effect of activating blood and removing blood stasis.