What Is a Xenograft?

Xenotransplantation or xenografting is the transplantation of tissue from one species into another, for example, from pig to human. Unlike the same kind of transplantation, there are large differences between the different kinds, so that the possibility of this kind of transplantation is very small.

Xenograft

Xenotransplantation or xenografting

The immunization system responsible for organizational exclusion will easily identify the foreign organization and strongly exclude it. Since animals can provide an endless source of transplants, xenotransplantation has always been a dream of people. Although pigs look very different from humans, they have similar organ structures and have become the focus of research in this field; monkeys are another attractive species.

In theory, it is the best solution to choose other primates that are closest to humans as the source of the transplant. However, primates are scarce, they are not easy to breed and breed, and they are expensive.

Title: Xenotransplantation

Author:

This book is written by experts who participated in the National Natural Science Foundation's major project "Basic Research of Xenotransplantation". It mainly introduces the basic theory of xenotransplantation, research progress, problems faced, and ideas and methods to solve these problems, including xenotransplantation. Mechanism and control measures of animal rejection, genetic modification and breeding of donor animals, prevention of zoonotic diseases, heterogeneous skin and

Chapter Xenotransplantation: History, Status, and Future

Chapter 2 Immunology Concepts and Problems Related to Xenotransplantation

Chapter III Hyperacute Rejection

Chapter 4 Genetic modification of donor pigs to prevent hyperacute rejection

Chapter 5. Endothelial Cell Activation and Delayed Xenograft Rejection

Chapter 6 Natural Killer Cells and Delayed Xenograft Rejection

Chapter VII Expression, Function and Regulation of Xenograft Related Genes

Chapter 8 Acute Cellular Rejection

Chapter IX Co-signaling Molecules and Xenograft Immunity

Chapter 10 Regulatory T Cells and Organ Transplantation

Chapter XI The Role of Thymus Modification and Thymus Transplantation in Xenograft Immune Tolerance

Chapter XII Xenotransplantation