What Is Cholestasis?
Cholestasis (cholestasis) is a pathophysiological process caused by bile secretion and excretion disorders. It is manifested by the excessive accumulation of bile components such as bile acid, cholesterol and bilirubin in the liver and systemic circulation, causing damage to liver cells and the body. Long-term persistent cholestasis will progress to liver fibrosis and even cirrhosis.
Cholestasis
- Cholestasis (cholestasis) is a pathophysiological process caused by bile secretion and excretion disorders. It is manifested by the excessive accumulation of bile components such as bile acid, cholesterol and bilirubin in the liver and systemic circulation, causing damage to liver cells and the body. Long-term persistent cholestasis will progress to liver fibrosis and even cirrhosis.
- The most common intrahepatic causes are viral or other hepatitis, drug toxicity, and alcoholic liver disease. Less common causes include primary biliary cirrhosis, cholestasis during pregnancy,
- Bile flow disorders can occur from
- Sinus basal membrane and capillaries
- 1.
- 1. Treatment for underlying causes
- For cholestasis with a clear underlying cause, if possible, all efforts should be made to cure or control the underlying disease. Obstructions caused by tumors and stones can be removed by surgical radical tumor resection or ERCP; repair of biliary tract stenosis can restore biliary drainage to normal; immunological damage to bile ducts may be effective; drug-resistant bile Sedimentation, stop relevant drugs in time.
- 2. Support and symptomatic treatment
- Ursodeoxycholic acid, dolyfosylcholine capsules, adenosylmethionine, phenobarbital. Traditional Chinese medicine preparations are beneficial for bile yellowing and enzyme reduction, such as Bupleurum, Baiji, Yinchen, Danshen, etc .; Itching treatment can be supplemented with fat-soluble vitamins, calcium and vitamin D.
- 3 Liver Transplantation
- Some types of end-stage cholestasis patients, such as primary biliary cirrhosis (PBS), primary sclerosing cholangitis (PSC), and biliary atresia, have a one-year survival rate of about 90%.