What Is Hepatitis A Immunoglobulin?

Hepatitis A antibody is a specific antibody against hepatitis A. Hepatitis A virus (HAV) is an icosahedral three-dimensionally symmetrical spherical particle with a diameter of 27-32 nm, without an envelope, and the core is a single-stranded positive-stranded RNA. HAV is a member of the Hepatovirus or Heparnavirus family of the picornaviridae. HAV is mainly transmitted through the hand-to-mouth route, with an incubation period of 15-50 days, with an average of 28 days. The virus is usually present in the patient's blood and feces 5-6 days before the patient's serum ALT increases. 2-3 weeks after the onset, with the production of specific antibodies in serum, the infectivity of serum and feces gradually disappeared. The laboratory diagnosis of HAV allows for antibody detection. The most commonly used clinically is to check the anti-HAV antibody by ELISA method.

Name: Hepatitis A antibody

category: Immunology

Normal hepatitis A antibody

ELISA (1) Hepatitis A antibody immunoglobulin M (anti-HAVIgM): negative (2) Hepatitis A antibody immunoglobulin G (anti-HAVIgG): negative

Clinical significance of hepatitis A antibodies

HAV infection combined with clinical can be used as diagnostic criteria for viral hepatitis A. Anti-HAVIgM is positive after HAV infection, but usually turns negative after 3-4 months. Once infected with hepatitis A, its total antibodies are positive. The first is the IgM antibody, while the IgG appears 3-12 weeks after infection and lasts for life. It can protect the body from HAV infection.

Hepatitis A antibody precautions

When tested: Anti-HAV-IgG appears late and lasts longer, often negative at the beginning of infection. Epidemiological investigations are commonly used. Anti-HAIgM positive can be diagnosed as hepatitis A. If a low titer is detected, the test should be repeated every 2 weeks, but attention should be paid to false positives caused by rheumatism. Anti-HAIgG positive indicates that they have been infected with HAV, but the double anti-HAIgG titer increased more than 4 times, which is also diagnostic. Not suitable for people: No.

Hepatitis A antibody test process

Anti-HAVIgM: Hepatitis A specific antibody- (anti-HAVIgM) appears early and can usually be detected within a few days of onset. The jaundice peaks, the antibody titer decreases from January to February, and most of it disappears from March to April. . It is an important indicator for the early diagnosis of hepatitis A. Common methods include enzyme-linked immunosorbent assay (ELISA) and solid-phase radioimmunoassay (SPRIA), which have high sensitivity and specificity. A routine test for patients with acute hepatitis. Rheumatoid factor-positive specimens may exhibit anti-HAVIgM false positives and should be noted. Anti-HAVIgG: When patients with acute hepatitis A have symptoms, anti-HAVIgG can be detected in the serum, the initial titer is low, and then gradually increases, reaching a peak in March after illness, maintaining a high level and low level within 1 year Can last for decades or even life in blood. For example, the anti-HAV IgG titer of the duplicate serum can increase the serum by more than 4 times during the recovery period, which can diagnose hepatitis A. Often because of the late visit of the patient, no early serum can be obtained, and the result of a 4-fold increase in antibody titer is not available, so this diagnosis method is basically not used clinically. Anti-HAVIgG is mainly used for epidemiological investigation to detect the immune level of the population. HAV-RNA uses cloned HAV cDNA fragments to make probes, and uses cDNA-RNA molecular hybridization technology to detect HAV-RNA in serum and feces in the acute phase of hepatitis A. Since the application of polymerase chain reaction (PCR) in the clinic, a more sensitive method for detecting HAV-RNA has been provided. The reverse transcription PCR (RT-PCR) method was used to first convert HAV-RNA to cDNA using reverse transcriptase, and then performed PCR detection. Positive HAV-RNA is direct evidence of acute infection with HAV.

Hepatitis A antibody related diseases

Antibodies, vomiting due to cold, trauma from internal trauma, vomiting due to cold in the stomach, menstrual fever, aversion to fever, nausea and vomiting, inhalation of vomitus, recurrent vomiting in children, etc.

Hepatitis A antibody related symptoms

Postoperative fever, postpartum fever, liver capsule tension, lower limb swelling and fatigue, palpitations with weakness, pale complexion, fever with joint swelling and pain, fever with lymphadenopathy and tenderness, fever with bleeding, fever with cough and expectoration , Chest pain, fever with chills, etc.

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