What Is the Connection Between Diabetes and Metabolic Disorders?

Metabolic disorder is a state of the body. It is a state in which the body's digestion, absorption, and excretion of the body appear pathological, and the state of unbalanced supply and demand is unbalanced. It can be expressed as a disorder of multiple substances. Disorders of various metabolic states vary. Disorders of glucose metabolism cause diabetes, disorders of lipid metabolism cause hyperlipidemia, disorders of uric acid metabolism cause gout, and so on. Electrolytes also have metabolic disorders, which cause corresponding disorders, such as hyperkalemia and hypokalemia. The mechanism leading to the occurrence of metabolic disorders is the mechanism of metabolic disorders.

Metabolic Disorders Mechanisms of Uremic Protein Metabolism Disorders

The onset of acute intermittent complications of uremia can affect protein metabolism, especially when incomplete protein and energy intake and drastic changes in the endogenous hormone environment. Several hormones can alter protein metabolism during uremia. INs are potent metabolic hormones that act on the protein metabolism of AA intake, but they are mostly disordered in ARF and not obvious in chronic kidney disease. Growth hormone also increased during RF, and the biological activity of INs-like growth factor I and the main composition effects of growth hormone axis were low. These hormonal disorders can promote protein catabolism. PTH also stimulates protein breakdown. Primary parathyroidism can improve nitrogen balance after parathyroidectomy, but hyperparathyroidism metabolism in uremia has not been described. Other catabolism hormones such as glucagon, cortisol, and catecholamines are often increased in uremic patients. These hormones increase gluconeogenesis and promote protein degradation. All ACRFs are involved in ACRF. In addition, vitamin D metabolism, interleukin work and PG also play a part. Uremic toxins also alter protein metabolism. It has been shown that uremic patients' plasma has an inhibitory effect on protein synthesis, while protease activity increases, and proteases are released from blood cells during dialysis. One hemodialysis may cause 89 free and 39 bound AA to be lost in the dialyzer. CAPD patients will lose about 8 to 99 blood proteins per day, and those with concurrent peritonitis will lose more.

Mechanisms of Metabolic Disorders in Renal Failure Protein Metabolism

CRF patients with protein and amino acid metabolism disorders often show decreased protein and amino acid synthesis, increased breakdown, and negative nitrogen balance. If not corrected in time, growth retardation may occur in children, and malnutrition manifests in adults, which seriously affects patient rehabilitation and wound healing, and increases the chance of infection, which is an important factor in increasing the incidence and mortality of CRF patients. During the pathogenesis of CRF, metabolic acidosis, insulin resistance, secondary hyperparathyroidism, increased steroid levels, uremic toxin and IGF-1 resistance, and the effects of some cellular mediators are all important factors that cause or aggravate protein metabolism disorders ^{[ 6]} .