What Is the Keratinocyte Growth Factor?

Keratinocyte growth factor (KGF-2) is a basic protein growth factor secreted by human subcutaneous tissue cells, which can specifically stimulate physiological processes such as metabolism of epithelial cells, including cell regeneration, differentiation, and migration. Keratinocyte factor, also known as FGF-10, is a late member of the large family of fibroblast growth factor (FGF) that was successfully cloned and is a commercialization of the Human Genome Project. It is an active soluble protein naturally occurring in the human body. It consists of 194 amino acid codes. Mature KGF has 163 amino acid residues. The N-terminus has a glycosylation site. It is mainly secreted by the subcutaneous tissue in the human body. The specific receptor that specifically binds to the surface of epithelial cells undergoes a complex signal transmission process to start the expression of genes involved in division and growth in epithelial cells, thereby stimulating the metabolism of epithelial tissues.