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Sterilization refers to the method of using physical or chemical methods to kill or remove all microbial propagules and their spores on the object or in the medium. The chemical reagents used in the sterilization process are collectively called sterilants. At present, the place where sterilants are applied in China is generally the sterilization of the environment in the sterile room. For example, the clean area of sterile drug production in pharmaceutical factories, the production workshops of medical device manufacturers, food processing production workshops, and biosafety laboratories need to strictly control the number of microorganisms. , Maintain an area of a certain cleanliness level.

Chemical sterilant

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Sterilization refers to the method of using physical or chemical methods to kill or remove all microbial propagules and their spores on the object or in the medium. The chemical reagents used in the sterilization process are collectively called sterilants. At present, the place where sterilants are applied in China is generally the sterilization of the environment in the sterile room. For example, the clean area of sterile drug production in pharmaceutical factories, the production workshops of medical device manufacturers, food processing production workshops, and biosafety laboratories need to strictly control the number of microorganisms. , Maintain an area of a certain cleanliness level.
Chinese name
Chemical sterilant
Nature
Disinfectant
According to the "disinfection technical specifications" chemical disinfectants on the sterilization of microorganisms, can be divided into high efficiency
The active chemical group carried by the sterilant has a chemical reaction after contacting with the microorganisms, causing the functional structure of the microorganisms (proteins, DNA, cell membranes, etc.) to be damaged, resulting in loss of life activities, thereby achieving the purpose of killing microorganisms (including spores and spores) )
At present, the place where sterilants are applied in China is generally the sterilization of the environment in the sterile room. For example, the clean area of sterile drug production in pharmaceutical factories, the production workshops of medical device manufacturers, food processing production workshops, and biosafety laboratories need to strictly control the number of microorganisms. Areas that maintain a certain cleanliness level.
With the development of the society, the requirements of the international community for the use of sterilants are becoming stricter: 1. The ingredients of the sterilants must be non-toxic and safe; 2. The sterilization effect of the sterilants meets the 10-6 power; 3. The agent is non-residual and non-corrosive to the items in contact; 4. Sterilizers require stable performance, safety and no explosion, easy to dissolve in water, and not pollute the environment.
For space environment sterilization, the sterilant can be fumigated by a fumigation generator (such as an electric rice cooker, a heater) or the professional sterilization equipment (such as a sprayer, a dry mist sterilization system) can be used to mist The atmosphere fills the entire area, and the doors and windows must be closed. For sterilization of the surface of the object, directly spray an appropriate amount, and then air dry or wipe dry with a sterile cloth.
Several types of sterilization are commonly used in clean areas: formaldehyde, glutaraldehyde, ethylene oxide, peroxyacetic acid, silver hydrogen ion, chlorine dioxide, isopropanol, lactic acid, and so on. Each has its own advantages and disadvantages, as for how to choose the correct analysis and judgment based on your actual situation.
In the use of sterilants, they must be used in strict accordance with the instructions. Since the sterilant itself is a dangerous product, it should not be used excessively. For example, peracetic acid is a strong oxidant, which is sensitive to various microorganisms and can kill all microorganisms. However, due to its strong oxidizing ability, it can stimulate and damage the skin and mucous membranes and corrode items at high concentrations. At the same time, long-term use of a large amount of sterilant will cause drug resistance and reduce the sterilization effect.
Inhalation in large quantities: Quickly withdraw from the harmful environment to fresh air, change contaminated clothing, wash hands and other exposed skin. If there is a large amount of contact or obvious discomfort, consult a nearby hospital as soon as possible.
Skin: After contacting high concentration disinfectant, rinse with plenty of running water in time, and wash with fresh soapy water. If the skin still has pain or irritation, go to the specialist hospital immediately after flushing.
Eyes: Immediately rinse with flowing water for at least 15 minutes immediately after splashing. If you still have severe eye pain, photophobia, tears and other symptoms, go to a nearby hospital as soon as possible.
Inadvertent poisoning: For adults, take no more than 200 ml of milk orally and take it multiple times. You can also take 3-5 raw egg whites. Generally do not induce vomiting or gastric lavage. Poisoning of iodine-containing disinfectants can take a lot of rice soup, starch syrup, etc. immediately. If you have severe gastrointestinal symptoms, you should go to a nearby hospital immediately.

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