How Do I Choose the Best Chewable Aspirin?

Chewable tablets are tablets that are swallowed after chewing in the mouth. Chewable tablets are generally the same size as ordinary tablets, and can be made into different shaped tablets according to needs.

Chinese name: Chewable tablets
Whether it contains preservatives: no

people suitble: most people
side effect: no

Definition of chewable tablets

Chewable tablets

Chewable tablets are mainly composed of drugs and suitable excipients. Chewable tablets are similar to ordinary tablets. Generally, starch, dextrin, powdered sugar, lactose, etc. are used as diluents, and polyvinylpyrrolidone (DED) and starch syrup are used as binders. Added the right amount of lubricant. Because the chewable tablet is swallowed after being crushed, there is no disintegration process, so there is no need to add a disintegrant. The biggest difference from ordinary tablets is that chewable tablets must have a good taste, so the main problem in the preparation process is the choice of flavoring agent.

Chewable tablets are easy to be accepted by patients, but most of the pharmaceutical ingredients, especially the traditional Chinese medicine ingredients, have poor taste. Chewable tablets absorbed in the mouth should use a less stimulating flavoring agent to reduce saliva secretion. Swallowing due to saliva secretion will reduce oral absorption of the drug, and flavoring agents should be omitted at this time. Chewable tablets that are not absorbed in the mouth generally choose sweet or slightly sour flavoring agents. After chewing, they should give people a cool feeling, and they can quickly dissolve in case of saliva. Generally, sucrose, lactose, glucose, citric acid, tartaric acid, etc. are used for compatibility tests to screen the appropriate flavoring agent ratio. Single syrup (such as orange peel syrup, cherry syrup, licorice syrup, etc.) is also more commonly used as a flavoring agent, which can not only correct the taste, but also mask the bad smell. Mannitol and sorbitol have no hard granules when chewing. They dissolve in the mouth to absorb heat and have a cooling sensation. They are also commonly used as flavoring agents in chewable tablets. Mannitol has good stability and no hygroscopicity. It is mostly used in chewable tablets of vitamins, acid-making drugs and other drugs to alleviate discomfort in the mouth; and it can form eutectic mixture with other sugars (such as sucrose, lactose, etc.). With good fluidity and compressibility, it can be directly compressed into tablets. If the drug tastes bitter, you can use aspartame, which has a sweeter taste, which is 150 to 200 times sweeter than sucrose. Obese patients. Diabetics can also choose stevia, glycyrrhizin, proteose, maltitol, xylitol, lactose, sorbitol and other flavoring agents. ^[2]

Chewing tablet preparation process

The preparation process of chewable tablets is not much different from ordinary tablets, and wet granulation is mostly adopted. The general process is as follows: drug pretreatment soft material granulation granulation and mixing tabletting analysis and testing finished product. Chemical drugs can be directly mixed with auxiliary materials, and a certain wetting agent or adhesive is used to make soft materials. When preparing Chinese medicine chewable tablets, the medicinal materials are generally extracted and separated to obtain an extract, and then the auxiliary materials are used to make soft materials. The active ingredients of some drugs may be affected by wet granulation. Direct powder compression can be used to improve drug stability, such as aspirin chewable tablets.

Chewable tablet production and storage requirements

The raw materials and excipients should be mixed uniformly. Tablets containing small or toxic or highly toxic drugs should be dispersed in an appropriate way according to the nature of the drug.

For drugs that are volatile or unstable to light and heat, appropriate methods such as shading and avoiding heat should be taken during the production process to avoid component loss or failure.

The materials, granules or semi-finished products before tabletting should be controlled to meet the needs of the tableting process, to prevent the tablets from mildew and deterioration during storage.

Flavoring agents, fragrances, and coloring agents can be added to the tablets according to compliance requirements.

In order to increase the stability, mask the bad odor of the raw material drugs, and improve the appearance of the tablet, the finished tablets can be coated with sugar or film. If necessary, film-coated tablets should be checked for residual solvents.

Chewable Tablets Chewable Tablets Features

The surface area of chewable tablets increases after chewing, which promotes the dissolution and absorption of the drug in the body, is convenient to take, has a hardness less than ordinary tablets, and has a good taste; Improve the effectiveness of medicine; chewable tablets are convenient to take, not restricted by time and place, can be used on time even under conditions of lack of water, especially suitable for children, patients with swallowing difficulties or poor gastrointestinal function, can reduce the drug on the stomach Intestinal burden; For children, the elderly, and patients with dysphagia, ordinary tablets are often difficult to take, and long-term medication may even cause psychological rejection, and chewable tablets can make up for this deficiency; Chewable tablets have A variety of colors and shapes, and good taste, so that children no longer afraid of taking medicine, good compliance; some bitter tablets are coated with sugar to cover the bitterness, the process is complex, the yield is low, and chewable tablets are made Later, the coating process was omitted and the production cycle was shortened ^[2] ^[3] .

Chewable tablet type

At present, the types of chewable tablets on the market are diverse and rich in varieties, mainly concentrated in the following types ^[2] .

Drug type	Representative chewable tablets	Features and functions
Calcium flakes	New cover in middle cover high calcium tablets	It is mainly used for the prevention and treatment of calcium deficiency. It is suitable for people who need calcium supplementation and easy to use.
	Citric acid-malate complex calcium	A new type of highly absorbable calcium material has the characteristics of good solubility, high bioavailability of calcium, and no toxic and side effects. The product has good taste and is easy to carry, especially suitable for children.
	Goji Berries Multidimensional Calcium Chewable Tablets	The fragrance is delicious, convenient to take, has calcium supplement and health care functions, and is used for calcium supplementation for children and the elderly.
Vitamins	Little Gold Vita Chewable Tablets	Various vitamins are the main medicines, which have the health function of supplementing multiple vitamins and minerals, and have a variety of flavors, which are especially suitable for children.
Antacids	Aluminum Magnesium Carbonate Chewable Tablets	For acute and chronic gastritis, gastric and duodenal ulcers and symptoms related to gastric acid
Food and health products	Oat dietary fiber chewable tablets, amino acid chelated calcium milk flavor chewable tablets, soy peptide chewable tablets, royal jelly chewable tablets	Nutrition

Chewable Tablets Clinical Application

In addition to the above-mentioned typical chewable tablets, researchers have begun to use the advantages of chewable tablets to solve clinical problems, for example, to improve the commonly used clinical but large adverse reactions to chewable tablets. The typical representative drugs are antipyretic and analgesic, anti-inflammatory and anti-rheumatic drugs aspirin. Low-dose aspirin can reduce the mortality of myocardial infarction, prevent arteriosclerosis, thrombosis and treat angina pectoris. Ordinary aspirin tablets have a stimulating effect on gastric mucosa. Aspirin slow-release tablets and enteric-coated tablets have a slow effect and cannot quickly relieve fever caused by pain and cold. The newly developed low-dose aspirin chewable tablets overcome the deficiency of the original dosage form. After being absorbed through the oral mucosa after chewing, it can not only reduce the adverse reactions of the gastrointestinal tract, reduce the irritation of the gastrointestinal tract, but also quickly play a role, similar to the onset time of ordinary tablets, and tests have proved that chewable tablets and ordinary tablets The agent is bioequivalent. After changing the traditional Longmu Zhuanggu granules to Longmu Zhuanggu chewable tablets, it is used to treat osteoporosis in the elderly, especially to prevent the increase of edema and heart strength when used in elderly patients with kidney disease and heart disease. Exhaustion. In addition, studies have shown that granules and chewable tablets are bioequivalent. The bioequivalence test of cefadroxil chewable tablets and cefadroxil ordinary tablets showed that the former absorbed quickly and had no adverse reactions, and the two preparations were bioequivalent. Stavudine, lamivudine, and nevirapine are all antiviral drugs. It has been confirmed in experiments on children with HIV infection that chewable tablets made of the above-mentioned stavudine, lamivudine, and nevirapine are fixed dose It is safe and has the same efficacy and bioavailability as capsules.