Is it safe to combine gemfibrozil and simvastatin?
The use of gemfibrozil and simvastatin together is contraindicated because it can pose the risks to the patient. In rare cases, doctors' provider may decide that the benefits of a combination of drugs outweigh risks. Patients who use a combination of drugs should be alert for side effects such as muscle pain and weakness, and should report these problems immediately. They may be a sign of serious complications that could lead to muscle and kidney damage. Simvastatin is a statin drug designed to reduce the level of poor cholesterol in the body. Gemfibrozil is a medicine in a class called fibretes, which controls cholesterol and triglycerides. These drugs can interact because it is known that fibrates increase the levels of statins in blood serum. If the body does not clean these drugs fast enough, known side effects as potential muscle damage to statins can become a more serious risk, as the concentration of drugs is higher. Others may develop a serious complication called rabdomyolysis. In this intenteRakci with medicines begins to attack his own muscle tissue, causing intense pain. The kidneys are not able to process the by -products of the muscle breakdown and may fail or be seriously injured.
Individual experience with gemfibrozil and simvastatin may vary. Some patients take medication without problems and can take them for years. It is important to discuss the possibility of interaction with the doctor and identify specific symptoms and symptoms so that patients know when to call if they have a problem. Rhabdomyolysis is a potentially very serious medical complication; Patients should not be afraid to call for fear and muscle pain as a doctor provider would rather be safe than sorry.
producers of both drugs recommend against a combination of gemfibrzil and simvastatin due to increased risk of side effects. More generally, statins and fibrates are not a good combination of patient treatment with high cholestEROLEM. In very specific cases, it may be necessary to mix drugs to check the patient's condition, in this case careful monitoring can be recommended. The patient might need regular blood tests to monitor kidney function and control of serum drugs. If problems occur, one or more medicines may need to be interrupted.