What Are the Different Uses for Atropine?

Anticholinergic drugs are M-receptor blockers. It is a racemic scopolamine extracted from the nightshade plant, belladonna, mandala, or scallion. Its alkali salt is colorless crystal or white powder, and it is easily soluble in water. ^[1]

Basic Information

Chinese name

atropine

English name

atropine Atropine Sulfatis, Atropinol

nickname

It can compete with acetylcholine on the acetylcholine M-receptor of the post-sympathetic ganglia fiber post-synaptic membrane, thereby antagonizing the muscarinic symptoms and central nervous symptoms caused by excessive acetylcholine on the post-synaptic membrane stimulation. It is often used clinically to inhibit glandular secretion, enlarge pupils, regulate ciliary muscle spasm, and relieve smooth muscle spasms such as gastrointestinal and bronchial. It can effectively control muscarinic symptoms and central nervous symptoms that occur when organophosphorus pesticides are poisoned. However, the tolerance to atropine sulfate is high when organophosphorus poisoning occurs, so the dosage should be large enough. Requires atropine: intramuscular or subcutaneous injection of atropine sulfate 1 to 2 mg during mild poisoning, repeat if necessary; double the dosage for moderate poisoning, repeat it after half an hour, and repeat as appropriate based on pupil changes; once for severe poisoning It can reach 3 ~ 5mg, and then repeat every 10 ~ 30min, until the pupils begin to dilate, the lungs sounds fade, or consciousness is restored, reduce the amount as appropriate. If the pupils become dilated and no longer shrink, or if you have mild flushing or mild restlessness, you can reduce or discontinue immediately. Atropine is a highly toxic drug, and patients should be closely monitored during the medication. Atropine has no significant effect on skeletal muscle tremor caused by organophosphate poisoning. Cholinesterase reactivating agents should be used in patients with moderate to severe illness. It cannot be used to prevent organophosphorus pesticide poisoning. ^[1]

Suitable for relief

Oral: 0.3 0.5mg / time, 3 times / day. Intramuscular, intravenous or subcutaneous intramuscular injection: 0.5mg / time.

This medicine has multiple pharmacological effects. When one of them is used clinically, the other effects become adverse reactions.

1. Common constipation, reduced sweating (severe perspiration can cause high fever), dry mouth, nose, and throat, blurred vision, flushed skin, and difficulty urinating (especially in elderly patients who are at risk of acute urinary retention), poor gastrointestinal motility, and stomach -Esophageal reflux.

2. Rarely increased intraocular pressure, allergic rash or herpes.

3. Long-term eye drops of this medicine can cause local allergic reactions (drug contact blephaconjunctivitis).

Not for use in patients with bronchial asthma. Intravenous atropine in pregnant women can cause fetal tachycardia. This product can be secreted into milk and has a lactation inhibiting effect. Infants and young children are extremely sensitive to the toxicity of this product, especially in children with spastic paralysis and brain injury. The response is stronger. When the ambient temperature is high, there is a risk of sudden rise in body temperature due to sweating. Please observe closely when applying.

Patients with glaucoma and benign prostatic hypertrophy and those with high fever are contraindicated.

Note: The above content is only for introduction, the drug use must be carried out by a regular hospital under the guidance of a doctor.