What Are the Most Common Sotalol Side Effects?

Sotalol hydrochloride injection is suitable for various life-threatening ventricular tachyarrhythmias. ^[1] .

Sotalol hydrochloride injection is suitable for various life-threatening ventricular tachyarrhythmias. ^[1] .

Drug Name

Sotalol hydrochloride injection

Hanyu Pinyin

Yan Suan Suo Ta Luo Er Zhu She Ye

Drug type

Occupational injury medical insurance

Use classification

Sympathetic inhibitor

Sotalol hydrochloride injection ingredients

The main ingredient of this product is sotalol hydrochloride, chemical name: (RS) -4 '-(1-hydroxy-2-isopropylaminoethyl) -methanesulfonylanilide hydrochloride.

Properties of Sotalol Hydrochloride Injection

This product is a colorless clear liquid.

Indications of sotalol hydrochloride injection

Suitable for all kinds of life-threatening ventricular tachyarrhythmias.

Specifications of Sotalol Hydrochloride Injection

2ml: 20mg

Sotalol hydrochloride injection dosage

The recommended dose is 0.5 to 1.5 mg / kg of body weight, diluted in 20 ml of 5% glucose, and a slow bolus within 10 minutes, which can be repeated after 6 hours if necessary. Note that this product, like other -blockers, has obvious racial differences. The dosage must be based on the patient's response and tolerance. Arrhythmia may occur at the beginning of treatment.

Adverse reactions of sotalol hydrochloride injection

Common side effects of intravenous injection are hypotension, bradycardia, conduction block, and other adverse reactions are fatigue, difficulty breathing, weakness, and dizziness. Similar to other antiarrhythmic drugs, this product can cause adverse reactions to arrhythmia in some patients, that is, it can induce new arrhythmias or exacerbate existing arrhythmias. These include induction of torsional ventricular tachycardia.

Contraindications of Sotalol Hydrochloride Injection

Forbidden in bronchial asthma, sinus bradycardia, second- or third-degree atrioventricular block (unless an effective pacemaker is placed), congenital or acquired prolonged QT interval syndrome, cardiogenic shock, Patients with uncontrolled congestive heart failure and allergies to this product.
When the creatinine clearance of patients is less than 60ml / h, this product should be used with caution.

Precautions for Sotalol Hydrochloride Injection

1. Avoid combination with drugs that can prolong the QT interval.
2. The electrolyte should be checked before applying this product. Patients with hypokalemia and hypomagnesemia should use this product after correction; especially for patients with long-term diarrhea or concurrent use of diuretics; should be used in combination with potassium-releasing diuretics Pay attention to potassium.
3. Patients with bronchospasm disease should avoid using this product.
4. Patients with Sinus Syndrome should be particularly careful when using this product to prevent sinus bradycardia, intermittent sinus, or sinus arrest.
5. This product has the function of -blockers, so it can inhibit myocardial contractility or cause heart failure. Therefore, patients with cardiac dysfunction should use this product with caution after using digitalis or diuretics to control cardiac dysfunction; in addition, both can prolong atrioventricular conduction and slow heart rate, and they should be alert to their arrhythmogenic effects.

Sotalol hydrochloride injection drug interactions

1. This product can prolong the QT interval, so drugs known to extend the QT interval, such as Class I antiarrhythmic drugs, phenothiazines, tricyclic antidepressants, terfenadine, etc., are not suitable for use with this product .
2. This product has no significant effect on the serum concentration of digoxin, but the arrhythmia caused by the combination of the two is more common.
3. This product combined with a calcium antagonist can produce an additive effect and cause hypotension, so it should be used with caution.
4. The combination of this product with reserpine, guanethidine and other drugs with -blockers can reduce sympathetic nerve tension, cause hypotension and severe bradycardia, and even fainting.
5. When this product is combined with -receptor agonists such as isoproterenol, it may be necessary to increase the dosage.

Pharmacology and Toxicology of Sotalol Hydrochloride Injection

Pharmacological effects: Like other beta-blockers, this product can slow heart rate and prolong AH interval and atrioventricular node conduction, but it is different from commonly used beta-blockers. It not only prolongs the atria, The effective refractory period of the ventricular muscle also prolongs the refractory period of the atrioventricular node, the Hispull field system, and the atrioventricular bypass bundle. By delaying and inhibiting outward potassium current, the action potential of the heart is prolonged, and the reactivation time of the slow calcium channel is prolonged by prolonging the repolarization of the ischemic myocardial reentry loop, thereby increasing the intracellular calcium and myocardial contraction at each heart Force, increase the threshold of ventricular fibrillation, and finally achieve anti-arrhythmic and anti-fibrillation effects.

Storage of Sotalol Hydrochloride Injection

Shading, sealed

Validity of Sotalol Hydrochloride Injection

Tentative two years