What Are the Most Common Tobramycin Side Effects?

Tobramycin dexamethasone eye ointment, the indications are 1. 1. Ophthalmic inflammatory lesions that respond to adrenocortical hormones and bacterial infections on the surface of the eye or situations at risk of infection; 2. Ophthalmic hormones are used in eyelids, bulbar conjunctiva, cornea, anterior segment of the eyeball and some inflammatory diseases such as infectious conjunctivitis, which can be potentially dangerous to hormones, and can reduce edema and inflammatory reactions. They are also suitable for chronic anterior uveitis, chemical, radioactive, burn and foreign body penetrating corneal injury; 3. Compound preparations with anti-infective ingredients can be used in areas where there is a high risk of ocular surface infections and when a large number of bacteria are expected to be potentially dangerous in the eyes; the unique anti-infective drugs in this product are effective against some common eye bacteria and pathogenic bacteria : Staphylococcus: Staphylococcus aureus and Staphylococcus epidermidis (thrombin positive and negative), including penicillin-resistant strains. Streptococcus: Group A beta hemolytic streptococcus, some non-hemolytic streptococci, and some pneumococci. Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morgan morganiformis, most common Bacillus strains, Haemophilus influenzae, Moraxella lacunae, Escherichia coli Haemophilus, Acinetobacter calcium acetate, and some Neisseria species.

Tobramycin dexamethasone eye ointment, the indications are 1. 1. Ophthalmic inflammatory lesions that respond to adrenocortical hormones and bacterial infections on the surface of the eye or situations at risk of infection; 2. Ophthalmic hormones are used in eyelids, bulbar conjunctiva, cornea, anterior segment of the eyeball and some inflammatory diseases such as infectious conjunctivitis, which can be potentially dangerous to hormones, and can reduce edema and inflammatory reactions. They are also suitable for chronic anterior uveitis, chemical, radioactive, burn and foreign body penetrating corneal injury; 3. Compound preparations with anti-infective ingredients can be used in areas where there is a high risk of ocular surface infections and when a large number of bacteria are expected to be potentially dangerous in the eyes; the unique anti-infective drugs in this product are effective against some common eye bacteria and pathogenic bacteria : Staphylococcus: Staphylococcus aureus and Staphylococcus epidermidis (thrombin positive and negative), including penicillin-resistant strains. Streptococcus: Group A beta hemolytic streptococcus, some non-hemolytic streptococci, and some pneumococci. Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morgan morganiformis, most common Bacillus strains, Haemophilus influenzae, Moraxella lacunae, E. ag Haemophilus, Acinetobacter calcium acetate, and some Neisseria species.

Drug Name

Tobramycin Dexamethasone Eye Cream

Drug type

Prescription drugs, topical drugs, medical insurance workers' injuries

Special medicine

Doping

Use classification

Other ophthalmic drugs

Tobramycin dexamethasone eye ointment ingredients

This product is a compound preparation, and its components are: tobramycin 0.3% and dexamethasone 0.1%.

Tobramycin Dexamethasone Eye Cream Properties

This product is white or off-white ointment.

Tobramycin dexamethasone eye ointment indications

1. Ophthalmic inflammatory lesions that respond to adrenocortical hormones and bacterial infections on the surface of the eye or situations at risk of infection;
2. Ophthalmic hormones are used in eyelids, bulbar conjunctiva, cornea, anterior segment of the eyeball and some inflammatory diseases such as infectious conjunctivitis, which can be potentially dangerous to hormones, and can reduce edema and inflammatory reactions. They are also suitable for chronic anterior uveitis, chemical, radioactive, burn and foreign body penetrating corneal injuries;
3 Compound preparations with anti-infective ingredients can be used in areas where there is a high risk of ocular surface infections and when a large number of bacteria are expected to be potentially dangerous in the eyes; the unique anti-infective drugs in this product are effective against some common eye bacteria and pathogenic bacteria :
Staphylococcus: Staphylococcus aureus and Staphylococcus epidermidis (thrombin positive and negative), including penicillin-resistant strains.
Streptococcus: Group A beta hemolytic streptococcus, some non-hemolytic streptococci, and some pneumococci. Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morgan morganiformis, most common Bacillus strains, Haemophilus influenzae, Moraxella lacunae, E. ag Haemophilus, Acinetobacter calcium acetate, and some Neisseria species.

Tobramycin Dexamethasone Eye Cream Specifications

Tobramycin 0.3% and dexamethasone 0.1%.

Tobramycin dexamethasone eye ointment usage dosage

1. Apply a cream about 1-1.5 cm long to the conjunctival sac 3 to 4 times a day.
2. The first prescription should not exceed 8 grams of ointment.

Adverse effects of tobramycin dexamethasone eye ointment

1. Adverse effects of hormones and anti-infective drugs can come from hormone components, anti-infective components, or a combination of both. There is no accurate data on the incidence of adverse reactions. The most common adverse reactions of ophthalmic tobramycin (topex) are: local ocular toxicity and allergic reactions, including itchy eyelids, edema, and conjunctival hyperemia. These adverse reactions occur in less than 4% of patients. Other adverse reactions similar to those of other aminoglycoside antibiotics for ophthalmology have not been reported. However, if you use tobramycin in the eye when using aminoglycosides throughout the body, you should monitor the concentration of the drug in the serum;
2. Adverse reactions related to hormone components include: increased intraocular pressure and possible glaucoma, occasional damage to the optic nerve, cataract formation under the posterior capsule, and delayed wound healing;
3 Double infection: A double infection may occur after a combination of antibiotics and hormones. Corneal fungal infections are prone to occur after long-term use of hormones.
Fungal infections should be considered for refractory corneal ulcers following the use of hormones. Due to the host's immunosuppression, secondary bacterial infections of the eye may also result.

Tobramycin Dexamethasone Eye Cream Taboo

1. Herpes simplex virus keratitis (dendritic keratitis), vaccinia, chicken pox and some corneal and conjunctival diseases caused by viral infections, mycobacterial infections in the eye, and fungal infections in the eye
2. Those who are allergic to any of the ingredients in this product;
3 Corneal foreign bodies are not completely removed.

Tobramycin Dexamethasone Eye Cream Precautions

1. Some patients may be allergic to topical aminoglycosides and should be discontinued if allergies occur;
2. Long-term use of eye hormones can cause glaucoma, damage to the optic nerve, decreased vision, visual field defects, and cataract formation under the posterior capsule. Intraocular pressure should be monitored routinely during use, even for children and uncooperative patients who have difficulty measuring. Long-term use of hormones can suppress the host's immune response and may increase the chance of secondary serious eye infections. The use of hormones in some lesions that lead to thinning of the cornea and sclera may lead to the occurrence of eyeball perforation. In acute purulent lesions of the eye, hormones can mask the infection and exacerbate existing infections;
3 The possibility of corneal fungal infection should be considered after long-term use of hormones. Like other antibiotics, long-term use may lead to excessive growth of non-sensitive microorganisms, including fungi. Once a secondary infection occurs, appropriate treatment must begin. When multiple treatments are needed or when clinical judgment suggests a secondary infection, patients should be examined with fluorescein corneal staining and slit-lamp biomicroscopy;
4 Research and evaluation on the carcinogenicity or mutagenicity of this product have not been performed. In the study of subcutaneous injection of tobramycin 50mg and 100mg / kg / day in rats, no adverse effect on fertility was found;
5. Medication should be kept out of reach of children.
6. Cross-sensitivity can occur with other aminoglycoside antibiotics.
7. To prevent the concentration of dexamethasone in the urine samples of athletes from exceeding the relevant regulations, athletes are advised to use this product with caution.
8. Do not touch the bottle mouth to the surface of any object, as this will contaminate the medicine in the bottle. Do not wear contact lenses while using this product.

Tobramycin and dexamethasone eye ointment for pregnant and lactating women

Pregnant women:
Animal tests have shown teratogenic effects. In two trials of pregnant rabbits, the use of 0.1% dexamethasone in the eye resulted in 15.6% and 32.3% teratogenicity. In tests of long-term use of dexamethasone in rats, an increase in the incidence of fetal retardation and stillbirth was also observed. No evidence of adverse effects of tobramycin for parenteral application on fertility and fetal development was found in parenteral studies in rats and rabbits. There are insufficient or well-controlled studies in pregnant women. This product should only be used during pregnancy if the potential benefits outweigh the potential danger to the fetus;
Breastfeeding women:
Adrenal corticosteroids used throughout the body can be present in human milk and inhibit growth, affect endogenous adrenal corticosteroid production or cause other side effects. It is unclear whether topical application of this product excretes milk. Because many drugs can be excreted from human milk, this product should be used with caution in lactating women.

Tobramycin dexamethasone eye ointment for children

The safety and effectiveness of this product for children under 2 years of age have not been established.

Tobramycin dexamethasone eye ointment for elderly

This experiment was not performed and there are no reliable references.

Tobramycin dexamethasone eye ointment drug interactions

This experiment was not performed and there are no reliable references.

Tobramycin dexamethasone eye ointment overdose

The clinical signs and symptoms (spot keratitis, congestion, tearing, edema, and itching of the eyelids) may be similar to the adverse reactions in some patients. If this product is used in excess, the excess medicine can be washed away with running water.

Tobramycin dexamethasone eye ointment pharmacology and toxicology

1. Adrenocortical hormones can inhibit inflammatory reactions caused by various factors, and may also delay wound healing. Adrenocortical hormones can inhibit the body's defense against infections. If this inhibition is of clinical significance, the combined use of antibiotics should be considered. Dexamethasone is a strong corticosteroid;
2. The antibiotic component (tobramycin) contained in the mixture is active against sensitive microorganisms. Experimental studies have shown that tobramycin is effective against the following microorganism-sensitive strains: Staphylococcus: Staphylococcus aureus and Staphylococcus epidermidis (thrombin-positive and negative), including penicillin-resistant strains. Streptococcus: Group A beta hemolytic streptococcus, some non-hemolytic streptococci, and some pneumococci. Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morgan morganiformis, most common Bacillus strains, Haemophilus influenzae, Haemophilus escherichia, Lactobacillus mora Bacillus, Acinetobacter calcium acetate, and some Neisseria species;
3 The susceptibility test of bacteria showed that some gentamicin-resistant microorganisms were still sensitive to tobramycin. No significant resistance to tobramycin has been found. However, resistant bacteria may appear over time;
4 There is no data on the extent of systemic absorption after use of this product. However, we all know that there is a systemic absorption effect when the drug is applied topically to the eye.
The usual physiological replacement for dexamethasone is 0.75 mg per day. When the dose is 4 times a day for both eyes, the dosage of dexamethasone will be 0.4 mg per day.

Pharmacokinetics of tobramycin dexamethasone eye ointment

This experiment was not performed and there are no reliable references.

Tobramycin Dexamethasone Eye Cream Storage

Store at 8 27 .

Tobramycin Dexamethasone Eye Cream Packaging

Aluminum tube, 3.5g / piece / box.

Tobramycin Dexamethasone Eye Cream

24 months.

Tobramycin dexamethasone eye ointment implementation standard

Import drug registration standard JX20000342 ^[1]