What is clozapine?

Clozapine is an anti-psychotic drug used to treat schizophrenia. It belongs to a drug class called atypical anti-psychotics and is the first drug of this type to be developed. The clozapine has a chemical formula C h _{19 cln 4 . It was first synthesized in 1961 and its first record was in Europe in 1971. It turned out to be somewhat dangerous due to the tendency to cause a blood disorder called agranulocytosis and was caused by use in 1975. Novartis, which produces a medicine and two companies that only sell it - Mylan Laboratories and Ivax Pharmaceuticals. Other companies can also launch generic versions of the drug. It is sold under the names of brands that differ in different parts of the world, including Clozaril®, Clopine, Denzapine, Kozapol and others.}

This medicine is considered to be highly effective for the treatment of schizophrenia, but is used as the last optionOptions for associated dangers. It is only prescribed for schizophrenia resistant to treatment, which is defined as schizophrenia that does not respond to at least two other less dangerous drugs. In the United States, US food and drug administration (FDA) requires clozapine packaging to indicate, among other things, warnings for many potentially dangerous side effects except agranulocytosis such as seizures, myocarditis, suppression of bone marrow and dementia. Several less serious side effects include drooling, constipation, muscle tremor, tardive dyskinesia and weight gain.

Despite its dangers, clozapine is still used to treat cases of schizophrenia that do not respond to other medicines. It is effective in the treatment of several symptoms associated with the disorder. Symptoms of schizophrenia are Genrally grouped into two categories: positive and negative. Positive symptoms include hallucinations and delusions. Negative symptoms include social withdrawal and emotional insulation.

clozapine isIt is known to treat both positive and negative symptones, and unlike many other psychoactive drugs, it can actually increase the clarity of the patient of thinking and perception of reality. There are other uses for this medicine, but are considered “outside the brand” or in experimental or testing phases. Patients with bipolar disorders, chronic insomnia, a schizoid personality disorder and a specific type of dementia called dementia Lewy-Body can benefit from clozapine, but these uses are not approved in most parts of the world, including the United States and Europe.

patients with other conditions should not take clozapine. Epileptics, patients with muscle disorder called myeloproliferative diseases and patients with liver damage or cardiovascular damage are considered too high to R AISS for serious health problems. It is also known that the drug interacts with other medicines, including fluvoxamine and benzodiazepines, in an unfavorable way.