What Is a Leukotriene Antagonist?

Leukotriene is a group of inflammatory mediators produced by arachidonic acid (AA) through 5-lipoxygenase (5-LOX) pathway metabolism. In vitro experiments show that it has about 1000 times stronger contraction effect on human bronchial smooth muscle than histamine and platelet activating factor (PAF). It can still stimulate mucus secretion, increase vascular permeability, and promote the formation of mucosal edema.

Leukotriene receptor antagonist

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1. Anti-inflammatory effect, prevention and reduction

LTRAs are well tolerated. Large-scale clinical trials conducted in recent years have confirmed that LTRAs has significant clinical efficacy compared with placebo. Long-term use has not found obvious side effects, is well tolerated, and is very effective in children. Safety. No deaths or serious adverse reactions have been reported. However, liver function should be measured if hepatic insufficiency or nausea, vomiting, hepatomegaly, and jaundice occur.