What Is Amisulpride?

Amisulpride, alias Amisulpride, is a white or nearly white crystalline powder chemical. Chemical name 4-amino- N -[(1-ethyl-2-pyrrolidinyl) methyl] -5- (ethylsulfonyl) -2-methoxybenzamide, the molecular formula is C ₁₇ H ₂₇ N ₃ O ₄ S with a molecular weight of 369.47900. Amisulpride is an antipsychotic and is mainly used clinically to treat schizophrenia.

Chinese name: Amisulpride
Foreign name: amisulpride

CAS number: 71675-85-9
Molecular formula: C17H27N3O4S

Introduction to Amisulpride

Amisulpride Basic Information

Chinese name

Chinese alias: 4-amino- N -[(1-ethyl-2-pyrrolidinyl) methyl] -5- (ethylsulfonyl) -2-methoxybenzamide; 4-amino- N- [(1-ethyl-2-pyrrolidinyl) methyl] -5- (ethylsulfonyl) -2-methoxybenzamide;

English name: amisulpride

English alias: Amisulprida; 4-amino-N-[(1-ethyl-2-pyrrolidin-yl) methyl] -5- (ethyl-sulfonyl) -2--methoxybenzamide; Amisulpridum [INN-Latin]; Amisulpiride; Socian;

CAS number: 71675-85-9

Molecular formula: C ₁₇ H ₂₇ N ₃ O ₄ S

Chemical structure:

Molecular weight: 369.47900

Exact mass: 369.17200

PSA: 110.11000

LogP: 3.27590 ^[1]

Amisulpride Properties

Appearance and properties: white or almost white crystalline powder

Density: 1.2 g / cm ³

Melting point: 124-128ºC

Boiling point: 558.9ºC at 760 mmHg

Flash point: 291.8ºC

Refractive index: 1.545

Storage conditions: 2-8ºC ^[1]

Description of Amisulpride Drug Related Drugs

Amisulpride classification name

Primary classification: Neurological drugs. Secondary classification: Antipsychotics, antidepressants, anxiolytics. Third classification: Other.

Drug Name

Chinese name: ammoniasulfur

English name: Amisulpride

Drug aliases: Amishubil, Socian, Solian ^[2]

Amisulpride drug dosage form

Tablet: 400mg.

Pharmacological effects of amisulpride

This product is a benzoamide antipsychotic. 1. See Shubilli. 2. This product has a high affinity for dopamine D2- and D3- receptors. ^[2]

Amisulpride Pharmacokinetics

This product can be absorbed from the gastrointestinal tract, and the bioavailability is 43% to 48%. There were two spikes in blood after oral administration, which occurred at 1 h and 3 to 4 h, respectively. The protein binding rate is very low. The metabolic rate is also low. A large amount of the original drug is excreted with urine. The terminal t _1/2 is about 12h. ^[2]

Amisulpride indication

It is mainly used for schizophrenia and also tried for depression. ^[2]

Amisulpride contraindications

1. Pregnant women, young children, breastfeeding and pheochromocytoma are forbidden.

2. Disabled in Parkinson's patients. ^[2]

Amisulpride precautions

1. (1) patients with hypertension; (2) patients with severe cardiovascular disease and hypotension; (3) patients with liver and kidney dysfunction; (4) pregnant women; (5) patients with mild mania; (6) patients with epilepsy; (7) Hyperthyroidism; (8) Patients with lung disease; (9) Urinary retention; (10) Those who are allergic to other benzamide antipsychotics.

2. Effects of drugs on children: The safety of newborns is uncertain.

3. The effects of drugs on the elderly: the elderly take sulpiride and the risk of adverse reactions increases.

4. The impact of drugs on pregnancy: the safety of pregnant women has not been determined.

5. The effects of drugs on breastfeeding: it is not clear.

6. Check or monitor before, after and during medication: liver and kidney function and blood image should be checked regularly.

7. Do not engage in dangerous activities such as driving and mechanical operation during the medication.

8. May be taken with food, water and milk to avoid stomach irritation.

9. In the treatment of schizophrenia, oral administration is the main method, and it can be administered by injection within 1 to 2 weeks of drug refusal or later.

10. Sedation and extrapyramidal symptoms can be reduced by reducing the dose or combining anti-parkinsonian drugs.

11. If allergic reactions such as rash and pruritus occur during medication, the drug should be discontinued.

12. It can cover up the symptoms of vomiting caused by tumor, intestinal obstruction and drug poisoning.

13. Do not stop the medicine suddenly, otherwise it may cause nausea, vomiting, stomach irritation, headache, rapid heartbeat, insomnia, tremor or worsening of the condition. It should be gradually reduced ^[2] .

Amisulpride adverse reactions

1. Mainly extrapyramidal reactions and sleep disorders. Others may include dizziness, fatigue, excessive excitement, irritability, nausea, difficulty swallowing, salivation, constipation, blurred vision, high blood pressure, amenorrhea, male hyperplasia, lactation, etc.

2. Whether or not it causes tardive dyskinesia is less controversial. ^[2]

Ammonia must be used

1. Acute phase can be taken orally at 400 800mg per day, divided into several doses, and can be increased to 1200mg per day if necessary. For patients with negative symptoms, 50 to 300 mg is administered orally. 2. The dose of renal insufficiency should be adjusted. The creatinine clearance rate is equal to half of the normal dosage for those with 30 to 60 ml per minute, and the creatinine clearance rate is equal to 10 to 30 ml per minute for only a constant 1/3. It can be injected intramuscularly at a dose of up to 800 mg per day ^[2] .

Corresponding effect of amisulpride

1. Tricyclic antidepressants (such as amoxapine, dutiapine, doxepin, amitriptyline, clomipramine, trimipramine, lofipramine, dexipramine, imipramine When used in combination with amisulpride, the two can affect each other's metabolism, leading to increased drug concentrations and increased toxicity. In addition, both have anticholinergic activity, and the anticholinergic effect is enhanced when combined. It should be used with caution.

2. Combined with belladonna, anticholinergic effect is enhanced.

3. Betel nut has a cholinergic effect, and combined with chlorpromazine can increase the extrapyramidal response of amisulpride ^[2] .

Amisulpride expert review

Has a strong antipsychotic effect. It has strong anti-stiffness, shrinking, hallucinations, delusions and insanity, and has a certain anti-depressant effect. There is no hypnotic effect, and it does not affect the normal activities of people after medication. In addition, it has a strong antiemetic effect. Oral is 160 times stronger than chlorpromazine ^[2] .