What Is Itraconazole?

Itraconazole is a new generation of triazole-based high-efficiency broad-spectrum antifungal drugs, which can combine with the fungal cytochrome P450 isoenzyme to inhibit its ergosterol synthesis. This product is suitable for dermatophytes, Candida, Cryptococcus neoformans, Porphyromonas sp., Aspergillus sp , Dermatitis and other infections are effective.

Basic Information

Drug Name
Itraconazole
Alias
Itaconazole
Main indications
Antifungal
Dosage
oral
Adverse reactions
allergy
Main medication contraindications
Prohibition of use with terfenadine, etc.
Dosage form
Pellet
CAS number
84625-61-6
Molecular formula
C35H38Cl2N8O4
Molecular weight
705.63

Itraconazole indication

It is mainly used for systemic infections caused by deep fungi, such as blastomycosis, histoplasmosis, coccidioidomycosis, pigmented fungal disease, sporotrichosis, and coccidioidomycosis. Can also be used for candidiasis and aspergillosis.

Clinical application of itraconazole

Oral, superficial fungal infection: once a day, 0.1g ~ 0.2g each time taken at meals, the course of treatment is 7 or 15 days. Onychomycosis short-term intermittent therapy; 0.2 g orally each time, 2 times a day, even for 7 days, with 3 weeks of withdrawal as a course of treatment. Nail ringworm disease is treated in this way for 2 courses; toenail ringworm disease is used in 3 courses. Pityriasis versicolor, vaginal candidiasis, fungal keratitis: Orally, 0.2 g once daily for 5 days, 3 days, and 3 weeks. Deep systemic fungal infections: Oral, starting at 0.2g per day, can be added to 0.4g per day when the effect is not good. The length of the medication period is determined according to clinical and test results.

Itraconazole adverse reactions

The effect of this product on liver enzymes is lighter than that of ketoconazole, but hepatic damage should still be watched for, and cases of liver failure have been found. With nausea and other gastrointestinal reactions, hypokalemia and edema can also occur. This product has a certain degree of cardiotoxicity. Multiple cases of congestive heart failure have been found and there have been deaths.

Itraconazole precautions

1. It is recommended to check liver function for those who continue to use the medicine for more than 1 month. Hypokalemia and edema may occur.
2. Women of childbearing age should take appropriate contraceptive measures when using this product until the next menstrual cycle after discontinuation.
3. Use with caution in patients with abnormal liver function.
4. Treatment should be discontinued when neurological symptoms occur.
5. For patients with renal insufficiency, it is recommended to monitor the blood concentration of this product to determine the appropriate dose.

Itraconazole medication contraindications

Those who are allergic to this product are prohibited, pregnant women and those with cardiac insufficiency are prohibited.

Itraconazole drug interactions

1. Enzyme-inducing drugs such as rifampicin can significantly reduce the oral bioavailability of this product. Therefore, the plasma concentration of this product should be monitored when combined with enzyme-inducing drugs.
2. This product interacts with warfarin and digoxin. Therefore, if these drugs are taken with this product, the dose should be reduced.
Note: The above content is only for introduction, the drug use must be carried out by a regular hospital under the guidance of a doctor.

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