Phenylacetone, colorless to light amber leaf-like crystals or liquid. Insoluble in water, ethylene glycol, propylene glycol and glycerin, soluble in alcohol, ether, benzene, toluene, etc. For general reagents, pharmaceuticals, flavors, fragrances and organic synthesis industries.
It is used in organic synthesis, as an intermediate for methotine and cholestyrol, and as a fragrance fixative.
Used in perfumes, for the synthesis of ephedrine and related compounds. [1]
By benzene and propionyl chloride obtained by condensation and hydrolysis. Benzene and anhydrous aluminum trichloride were put into a glass-lined reaction pot, cooled with stirring to 10 ° C, and a mixed solution of propionyl chloride and anhydrous benzene was added dropwise. After dripping, slowly raise the temperature to 20 ° C for 1h. The reaction solution was added to ice water, and was hydrolyzed by stirring at 30 ° C or lower. The oil layer was separated and separated, washed with sodium hydroxide solution, and then washed with water to neutrality, and distilled under reduced pressure. The distillate of 112 ~ 120 ° C (4.0kPa) was collected, which was phenylacetone with a yield of 85%. [1]
Oral: The treatment amount is 300-900mg per day, divided into 4-6 times. Maintain the amount of 300 to 600 mg per day, divided into 2 to 4 times. If necessary, it can be given intravenously under intensive monitoring, 70 mg every 8 hours, or followed by a intravenous drip (20-40 mg per hour). [2]
1. As this product has
CAS number: 93-55-0
MDL number: MFCD00009309
EINECS number: 202-257-6
RTECS number: UG7175000
BRN number: 606215
PubChem number: 24887922 [3]
Traits: colorless to light amber leaf-like crystals or liquid. Has a strong and lasting aroma.
Gas-phase standard combustion heat (enthalpy) (kJ / mol): -4862.0
Gaseous standard heat of formation (enthalpy) (kJ / mol): -108.7
Liquid phase standard combustion heat (enthalpy) (kJ / mol): -4803.5
Standard heat of formation (enthalpy) (kJ / mol): -167.2
Critical pressure (kPa): Not determined
Logarithm of oil-water (octanol / water) partition coefficient: not determined
Upper explosion limit (%, V / V): Not determined
Lower explosion limit (%, V / V): Not determined
Solubility: miscible with methanol, absolute ethanol, ether, benzene, toluene, insoluble in water, glycerol, ethylene glycol, propylene glycol. [3]
Molar refractive index: 40.91
Molar volume (cm 3 / mol): 137.4
Isometric Zhang Rong (90.2K): 332.2
Surface tension (dyne / cm): 34.1
Polarizability (10 -24 cm 3 ): 16.21 [3]
Hydrophobic parameter calculation reference value (XlogP): None
Number of hydrogen-bonded donors: 0
Number of hydrogen bond acceptors: 1
Number of rotatable chemical bonds: 2
Number of tautomers: 2
Topological molecular polar surface area 17.1
Number of heavy atoms: 10
Surface charge: 0
Complexity: 112
Number of isotope atoms: 0
Determine the number of atomic stereocenters: 0
Uncertain number of atomic stereocenters: 0
Determine the number of chemical bond stereocenters: 0
Uncertain number of chemical bond stereocenters: 0
Number of covalent bond units: 1 [3]
Exist in flue-cured tobacco leaves. [3]
This product should be sealed and stored in a cool place. [3]
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. After accidental contact with eyes, rinse immediately with plenty of water and seek medical advice.
