What Is Serum Creatinine?

The exact name of serum creatinine (Cr) is blood creatinine. Blood creatinine is generally considered to be endogenous blood creatinine, which is a product of human muscle metabolism. In muscle, creatine mainly slowly forms creatinine through an irreversible non-enzymatic dehydration reaction, is released into the blood, and is excreted with urine. Therefore, blood creatinine is closely related to the total muscle mass in the body and is not easily affected by diet. Creatinine is a small molecule substance that can be filtered through the glomerulus and is rarely absorbed in the renal tubules. Almost all creatinine produced in the body is excreted with urine and is generally not affected by urine output. Clinical detection of serum creatinine is one of the main methods to understand renal function, and it is an important indicator of renal function. An increase in serum creatinine means damage to renal function.

Basic Information

Chinese name

Serum creatinine

Foreign name

serum creatinine, Scr

Types of

noun

Field

medicine

Related

Serum, kidney function

Clinical significance of serum creatinine

1. Increased serum creatinine

(1) Acute and chronic glomerulonephritis, nephrosclerosis, polycystic kidney disease, rejection after kidney transplantation, etc. For patients with chronic nephritis, the higher the serum creatinine level, the worse the prognosis. When uremia and severe congestive heart dysfunction, creatinine concentration increases.

(2) Dehydration, blood loss, shock, heart failure, strenuous physical activity, acromegaly, and gigantism, and increased serum creatinine.

2. Decreased serum creatinine

Muscle atrophy, severe liver disease, leukemia and renal insufficiency.

3. Serum creatinine concentration for the breakdown of chronic renal insufficiency

The first stage (compensatory stage of renal insufficiency): GFR50 80mL / min; Scr133 177mol / L.

The second stage (decompensation stage of renal insufficiency): GFR50 20mL / min; scr178 442mol / L.

The third stage (period of renal failure): GFR20 10mL / min; scr443 707mol / L.

Phase 4 (Uremic Phase): GFRmin; scr> 707 mol / L.

Reference range of serum creatinine

(The normal value of serum creatinine varies from hospital to hospital. For details, please refer to the normal reference value of the testing hospital.)

Generally: Male: 44 133mol / L Female: 70 106mol / L

Serum creatinine considerations

Venous blood was collected on an empty stomach for 12 hours.