What Is Silver Sulfadiazine?

Silver sulfadiazine (INN: Silver sulfadiazine , or silvadene) is a sulfonamide / silver salt [2] antibacterial drug, CAS number is 22199-08-2, chemical formula is C10H9AgN4O2S, is a white or almost white crystalline powder It is easy to deteriorate when exposed to light or heat. It is used to treat burn wound infections. In addition to controlling infections, it can also promote wound dryness, crusting and promote healing. After applying the medicine, it will become dark brown when encountering light.

Silver sulfadiazine

Silver sulfadiazine (INN: Silver sulfadiazine , or silvadene) is a

1. Those who are allergic to sulfa drugs and silver salts are contraindicated.

2. Use with caution in pregnant and lactating women.

3 This product may cause

If you are using other drugs, you should consult your doctor or pharmacist before using this product.

1. The product can pass through blood

due to

Elderly patients have an increased chance of serious adverse reactions with sulfa drugs. Such as a severe rash,

The blood concentration of sulfa should not exceed 200 g / ml. If it exceeds this concentration, the incidence of adverse reactions will increase and the toxicity will increase.

Silver sulfadiazine

Huang 'an Midingyin

Sulfadiazine Silver

[Revised]

[Character] This product is insoluble in water, ethanol, chloroform or ether, and it is soluble in ammonia test solution.

[Updated]

[Inspection] The related substances should be protected from light. Take about 50mg of the test product, put it in a 10ml measuring bottle, add 3.0ml of ammonia water to dissolve it, dilute to the mark with methanol, shake well, and use it as the test solution; take a precise amount of 1ml, put it in a 100ml measuring bottle, and use methanol-ammonia (4: 1) Dilute to scale, shake well, and use as control solution. According to the thin layer chromatography (Appendix VB) test, take 10 l of each of the above solutions, point them on the same silica gel GF254 thin layer plate, and use chloroform-methanol-aqueous ammonia (7: 4: 1) as the developing agent to develop. Allow to dry and inspect under an ultraviolet light (254nm). If the spot of the test solution shows impurity spots, it must not be deeper than the main spot of the control solution (1.0%).

Take about 2g of nitrate, weigh it accurately, place it in a beaker, add 30ml of water precisely, shake for 20 minutes, filter with a nitrate-free filter, accurately measure 3ml of the filtrate, and place it in a test tube with a stopper; Salt control solution (take 0.326g of potassium nitrate, dissolve it with water and dilute it to 1000ml, and shake to obtain. 1ml contains about 200g NO3) 1ml, put in another stopper test tube, add 2ml of water, shake well; and then measure the water accurately 3ml was placed in a blank stoppered test tube. Put three test tubes in an ice bath, and slowly add chrome acidification solution (take 50mg of chromic acidification, add 100ml sulfuric acid in the ice bath to dissolve and cool) 7.0ml, place in the ice bath for 3 minutes, and shake to Swirly. The test tube was removed from the ice bath and left for 30 minutes. According to the ultraviolet-visible spectrophotometry (Appendix IV A), measure the absorbance at a wavelength of 408 nm. The absorbance of the test solution must not be greater than the absorbance of the control solution (0.1%).