What Is Spectinomycin?

[Alias] Clin; Lin Bizhi; Actinomycin; Qimicin; Penicillin; Treatment of Gonorrhea; Spectinomycin;

Spectinomycin Hydrochloride

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[Alias] Clin; Lin Bizhi; Actinomycin; Qimicin; Penicillin; Treatment of Gonorrhea; Spectinomycin;

[Foreign name] Spectinomycin, Dilspectin, Kemipi, Spectam, Togoplus, Trobicin

[Ingredients] This product is an aminocycloalcohol antibiotic produced by the combination of a neutral sugar and an aminocycloalcohol glycoside produced by streptomycin Streptomyces spectabilis.

[Character] The common hydrochloride is white or almost white crystalline powder, easily soluble in water, and the pH of 1% solution is 3.8--5.6.

Chinese name

Spectinomycin Hydrochloride

Foreign name

Spectinomycin

Use

Treatment of acute gonorrhea and cervicitis

Formula

t1 / 2 = 2.5 hours

Use

Single dose 2g

[Pharmacological action and use] This product has a moderate antibacterial effect on aerobic Gram-negative bacteria such as E. coli, Klebsiella, Enterobacteriaceae, Proteus, Acinetobacter, Haemophilus influenzae, Morganella, etc Neisseria gonorrhoeae is particularly effective. Among Gram-positive bacteria, it is effective against Group A Streptococcus and Staphylococcus epidermidis. Among atypical pathogenic bacteria, it is sensitive to Mycoplasma urolyticus. t1 / 2 = 2.5 hours. Commonly used in the treatment of urethritis, proctitis, acute gonorrhea, cervicitis and other patients with uncomplicated gonorrhea caused by penicillin-resistant bacteria and patients' resistance to penicillin. Mainly used in urinary tract infection caused by Neisseria gonorrhoeae, suitable for patients resistant to penicillin and tetracycline.

[Usage and dosage] 1. Mild: intramuscular injection, single dose 2g. Severe: 2g each time, 2 times a day. Children: 40mg / kg daily, single dose. 2. Intramuscular injection: 2g once. The special diluent (0.9% benzyl alcohol solution) 3.2ml. Inject it into a medicine bottle, shake it vigorously to make a suspension (about 5ml), and use a thick needle to inject it into the deep muscles outside the upper buttocks. Generally only used once. For patients who have not been cured with other antibiotics, they can be administered at a dose of 4g, that is, 4g once, divided into the upper and lateral glutes on both sides, or 2g intramuscularly, and twice a day.

[Adverse reactions] Occasionally rash, nausea, dizziness, fever, chills, insomnia headache, and local discomfort caused by injection. The second dose showed damage to liver and kidney function and blood cell reduction. Occasionally reduced hemoglobin and hematocrit, decreased creatinine clearance, and increased values of alkaline phosphatase, BUN, and transaminase. There are also cases of decreased urine output.

[Precautions] Allergic patients are prohibited, and pregnant women and newborns should be used with caution. It cannot be used for the treatment of syphilis, nor for intravenous administration. Avoid in patients with kidney disease.

[Specifications] Injection: 2g, with 5ml dilution (hydrochloride)