What is anti -malarial resistance?

Antimalarial resistance is the ability of microorganisms that cause the malaria of the disease to withstand the effects of medicines used to treat the disease. This is an example of a wider phenomenon of drug resistance, evolutionary adaptation of types of microorganisms causing diseases that provide them with greater ability to survive the treatment used to cure them. Malaria is a disease caused by the only cell of the family plasmodium , which is transmitted to people, even if the bite of a mosquito bearing these organisms. The malaria of the disease is an important health problem in most of the world and has been one of the primary goals of many initiatives in poor countries, which has been the development of antimala leesis to an important global health problem.

There are number of plasmodium that cause malaria in different species, although the vast majority of malaria in humans are caused by the type plasmodium falciparum . Malaria causes symptoms such as vomiting, convulsions and anemia and usually causes charactEristic alternating cycle of fever and chills in patients. It is potentially fatal and can also cause brain damage, especially in infected children, damage to retinees and dead or low birth in infected pregnant women. Malaria is extremely common diseases, especially in tropical or subtropical areas, where mosquitoes are very friendly heat and climate humidity, with an estimated 250 million infections and 1 million deaths per year.

Like other forms of drug resistance, antimalarial resistance develops due to evolutionary pressures placed on the types of the Plasmodium human medicine. When it enters the use of a new antimalarial drug, it tends to be highly effective, because the species to focus on, to endure it, because there was no advantage for such a ability. Once a new medicine is used, these changes change and all individual classesNew species that are less sensitive to a drug than typical of the species will have a better chance than their less resistant guys to survive and reproduce, which means that the next generation will descend primarily from them, and bears genes of organisms that are most able to survive the drug. The new genetic mutations increasing resistance occurring in subsequent generations that would be unnecessary or even harmful before the advent of the drug will now be advantageous for organisms that carry them, and they become more likely to be handed over.

6 As a result, an antimalarial drug becomes less and less effective. Antimalarial drugs on which malaria is resistant may vary from region to region, depending on the history of infection and treatment in this area.

This is a very important impulse for the development of new drugs, because the ability of modern medicine to reduce the loss of human health and life caused by malaria depends on the creation of drugs that this disease failed. The more you useThe medicine, the faster it is likely to develop due to selective pressure, so the initiatives in the fight against malaria usually focus on a large focus on preventing mosquitoes to spread people's infection in the first place by the repellents or physical barriers.