What is the difference between prednisone and prednisolone?

The difference between prednisone and prednisolone is that one is the forerunner of the other. Prednison is activated by enzymes in the liver to turn into prednisolone. They have similar uses, but prednisolone is easier to absorb the body. Prednisolone is usually used when it is a toxicity of liver or liver failure.

Although they have many similarities, there are some differences between prednisone and prednisolone. First, it has a different chemical structure and molecular weight. Prednison is also administered only orally, while prednisolone can be administered orally or topically or even if necessary. Finally, prednisolone has a greater anti -inflammatory effect, although not particularly significant. They are used for various problems that are chronic or acute inflammation. Some common examples are Crohns diseases, rheumatoid arthritis, severe allergies, cluster and migraine headaches and ulcerative colitis. Other examples are time arteritis, Bell's palsy, multiple sclerosis, vasculitis, acute lymphoblastic leukemia and autoimmune hepatitis.

both drugs also suppress the immune system and can be administered when organ transplant is carried out to prevent the body from rejecting the implanted organ. Prednisone and prednisolone can also be used in cases of hyperrative adrenal glands, as in the case of congenital adrenal gland - groups of diseases in which the adrenal glands do not work properly. Both can also be used to help fight tumors because of their immunosuppressive abilities.

Prednison and prednisolone also have similar side effects. In a long -term horizon, they may cause problems such as Cushing syndrome, a disease that includes adrenary glands; fluid retention; osteoporosis; glaucoma; cataracts; Diabetes type 2 mellita; And even depression when the dosage is reduced or stopped completely. There are also a number of short -term ledmore effects such as insomnia; increased blood glucose, especially in people who have diabetes mellitus; reduced or blurred vision; increased thirst; cataract formation; confusion; And other psychological problems.

both prednison and prednisolone cause the adrenal suppression, so they can cause the adrenal glands to stop functioning properly if used for more than seven days. If the use of prednisone or prednisolone is suddenly stopped, this can cause a serious condition known as the adrenal crisis. For this reason, the dose must be gradually reduced over time to provide the adrenal with the chance to start working properly.