What is pyridoxamine?

pyridoxamine, a form of vitamin B6, which naturally occurs in foods such as carrots, walnuts, chicken and fish, was once sold as a food supplement in the United States. In the form of pyridoxamine chemicals does not work as vitamin B6; First, it must be converted into its active shape of pyridoxic 5-phosphate by one of the vitamin rescue routes. It seems that in its chemical structure it is very similar in its chemical structure, it does not seem to be the same risk of causing peripheral neuropathy when high doses are used for a long time.

Since several studies indicated that it was more effective than other examination drugs in preventing renal tissue damage associated with diabetes at a late stage, its low incidence of side effects made it an ideal new drug candidate. Although research for the development of vitamin for the treatment of kidney disease has stopped since then, in 2009 pyridoxamine classified the United States (FDA) as an investigation medicine, ZAKAIt is stating its sale as a food supplement.

Before the prohibition, vitamin was recommended by some alternative physicians as an anti -aging medicine. This was partly due to the findings of several studies, suggesting that the compound inhibited the formation of certain free radicals produced when the body burned fat. Some research also indicated that it was a more efficient radioProtective agent than the only drug approved by the FDA used to protect against ionizing radiation damage. Since aging is partly due to DNA damage caused by free radicals and radiation, vitamin may act as a preventive agent.

pyridoxamine was best known for its ability to prevent the formation of advanced glyce terminal products. Advanced glycation terminal products have been involved in a number of serious conditions related to age vcluding atherosclerosis, Alzheimer's disease, illnessLiver, kidney disease and neuropathy. It is assumed that the binding to cells in almost every body system develops its pathological effects by increasing oxidation stress and causes secretion of inflammatory compounds, oxidize lipoproteins with low-density cholesterol and interfere with vascular dilatation and permeability. By reducing the age in the bloodstream, it is possible that pyridoxamine may slow down the progression of diseases associated with them. Despite the potential positive effects of pyridoxamine on multifactorial chronic diseases, in the United States will not be available as a medicine until the Study IIB and Phase III has been completed.