What Are Coagulation Factors?

Coagulation factors are the various protein components involved in the blood coagulation process. Its physiological role is to activate when blood vessels bleed, stick to platelets and plug leaks in blood vessels. This process is called coagulation. The whole coagulation process can be roughly divided into two stages, the activation of prothrombin and the formation of gelatinous fibrin. They are partially produced by the liver. Can be inhibited by coumarin. For unified naming, the World Health Organization is numbered in Roman numerals according to the order in which it was discovered. There are clotting factors , , , , , , , , X, , , Xlll, etc., and after factor XIII The discovered coagulation factors, after years of verification, are considered to have no decisive effect on coagulation function, and are no longer included in the number of coagulation factors. Factor VI is actually the fifth factor that has been activated, and factor VI has been de-named.

clotting factor

Coagulation factors are the various protein components involved in the blood coagulation process. Its physiological role is to activate when blood vessels bleed, stick to platelets and plug leaks in blood vessels. This process is called coagulation. The whole coagulation process can be roughly divided into two stages, the activation of prothrombin and the formation of gelatinous fibrin. They are partially produced by the liver. Can be inhibited by coumarin. For unified naming, the World Health Organization is numbered in Roman numerals according to the order in which it was discovered. There are clotting factors , , , , , , , , X, , , Xlll, etc., and after factor XIII The discovered coagulation factors, after years of verification, are considered to have no decisive effect on coagulation function, and are no longer included in the number of coagulation factors. Factor VI is actually the fifth factor that has been activated, and factor VI has been de-named.

Chinese name

clotting factor

Foreign name

blood coagulation factor

Types of

Protein component

Name Party

Factor I,

PT extension

PT extended representative

Activation system

From

Hemophilia is a group of hereditary bleeding disorders that cause severe coagulopathy due to the lack of certain coagulation factors in the blood. Both men and women can develop the disease, but the vast majority of patients are men. Including hemophilia A (A), hemophilia B (B), and factor XI deficiency (formerly known as hemophilia C). The former two are sex-linked recessive inheritance, and the latter are incomplete recessive inheritance of autosomes. Hemophilia is the most common congenital hemorrhagic disease, and bleeding is the main clinical manifestation of the disease. Treatment methods include local hemostasis and replacement therapy. Emerging therapies in the latter include recombinant human coagulation factor (recombinant human coagulation factor VIIIa for injection, Nozzle) treatment. Due to its characteristics of no artificial pollution and high safety, it has a tendency to spread in the future.