What Are Nicotinic Acetylcholine Receptors?

There are two types of acetylcholine receptors: muscarinic receptors (M receptors --- G protein-coupled receptors), which produce parasympathetic excitatory effects, that is, cardiac activity inhibition, bronchointestinal smooth muscle, and bladder detrusor contraction , Digestive gland secretion increases, pupils shrink. Atropine is a muscarinic receptor blocker. Nicotinic receptor (N receptor --- ion channel receptor), N1 is located in the post-synaptic membrane of the ganglion, which can cause the excitatory neurons of the autonomic ganglion to excite, and the N2 receptor is located in the skeletal muscle endplate membrane. Can cause motor end-plate potential, causing skeletal muscle excitement. Hexadecyl quaternary amines mainly block N1 receptor function, decaquat quaternary amines block N2 receptor function, and tuberosporine can simultaneously block N1 and N2 receptor functions.

Acetylcholine receptor

There are two types of acetylcholine receptors: muscarinic receptors (M receptors --- G protein-coupled receptors), which produce parasympathetic excitatory effects, that is, cardiac activity inhibition, bronchointestinal smooth muscle, and bladder detrusor contraction , Digestive gland secretion increases, pupils shrink. Atropine is a muscarinic receptor blocker. Nicotinic receptor (N receptor --- ion channel receptor), N1 is located in the post-synaptic membrane of the ganglion, which can cause the excitatory neurons of the autonomic ganglion to excite, and the N2 receptor is located in the skeletal muscle endplate membrane. Can cause motor end-plate potential, causing skeletal muscle excitement. Hexadecyl quaternary amines mainly block N1 receptor function, decaquat quaternary amines block N2 receptor function, and tuberosporine can simultaneously block N1 and N2 receptor functions.

Chinese name

Acetylcholine receptor

English name

acetylcholine receptor

nickname

AChR

Nature

Intrinsic membrane protein

AChR

[Specimen collection]

Fasting venous blood 2.0ml.

[Normal reference value]

negative.

[Clinical significance] 285

Anti-acetylcholine receptor antibody is an autoantibody in the serum of patients with myasthenia gravis. In particular, the positive rate of patients with thymoma is higher, which can reach 93% to 100%. The positive rate of those without thymoma was low, ranging from 17.2% to 88.7%. Anti-acetylcholine receptor antibody is one of the important reasons for the development of myasthenia gravis.

Features

Acetylcholine is both a peripheral and a central cholinergic neurotransmitter and specifically acts on various choline receptors. There is no clinical use value, generally only for experimental use.

The pharmacological effects of acetylcholine are: 1. Slow heart rate, partial vasodilation, weakened myocardial contractility, decreased blood pressure, gastrointestinal tract, urinary tract and bronchial smooth muscle excitement. Glandular secretion increases, pupil sphincter and ciliary muscle contraction.

2. Exciting the N2 receptors on the motor nerve end plate and contracting skeletal muscle. At higher doses, diffuse muscle contractions, muscle spasms, etc. may occur