What Is Citrate Synthase?
Citrate (Si) -synthase
Citrate synthase
discuss
- Chinese name
- Citrate synthase
- English name
- citrate (Si) -synthase
- Citrate (Si) -synthase
- The system name is: acetyl-CoA: oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S) -carboxymethyl forming], EC2.3.3.1 (formerly EC4.1.3.7).
- An enzyme that catalyzes the reaction of acetyl CoA from glycolysis or other dissimilation reactions with oxaloacetate to form citric acid. Because the release of CoA from acetyl CoA is an exothermic reaction (G0 =-7.7 kcal), so that the equilibrium tends to generate citric acid.
- This enzyme controls the entrance of the tricarboxylic acid cycle and is subject to a variety of regulations. It is an allosteric enzyme that is allosterically inhibited by NADH, ATP, and -ketoglutarate. Succinyl-CoA competes with acetyl-CoA, and AMP counteracts the inhibition of ATP and acts as an activation.
- The rate-limiting step that becomes the tricarboxylic acid cycle in the liver and other tissues exists in the mit-ochondrial matrix.