What is the nitric oxide synthase?

nitric acid (NO) is a small molecule with a double covalent bond between nitrogen and oxygen atoms. It is produced in the human body by a two -stage synthesis of amino acid arginine, a catalyzed enzyme synthase of nitric oxide (nose). The nose is present in three forms in different tissues. Highly reactive NO is produced as a stress reaction and is both cytotoxin and cytoprotective agent. Its production in epithelial cells is controlled by epithelial synthase of nitric oxide (Enos). Nitric oxide synthase is bound in the cell membrane on the cytoplasm side or in the membranes of various organelles. Not in epithelial cells is not helpful in controlling vascular contraction and dilatation. The anchorage of Enos in the cell membrane helps the cell to limit the activity of NO to small areas.L, breast and brain tumors. Understood by inos deactivates energy metabolism by reacting with deoxyribonucleic acid cells (DNA) and eventually kills the cell. Good tissue can be injured in the fight for killing tumor cells. FormNo synthesized with Enos fights the invasion of bacterial cells, while it kills the surrounding somatic cells without distinction. Each type of death of host cells can lead to toxic shock, a serious complication for patients with a compromised immune system.

in the nerve cells and around them does not set as a short -term signal transmitter that is easily distracted through membranes. Neuronal synthase of nitric oxide (nos) is continuously recycled to form NO, because it is stable after only seconds than neutralized by water molecules. The expression of the enzyme is regulated by the concentration of calcium ions. It is assumed that not it is involved in the transformation of the short -term long -term memory through a process called long -term potentiation (LTP).

Inhibitors of nitric oxide synthas are neuroprotective because they reduce the availability of free radical no. Compounds in this class include hydrophilic inITAMIN C and hydrophobic vitamin E. These and other molecules were examined with the hope of slowing neurodegenerative conditions such as Parkinson's disease. Since 2010, direct links have not been proven. One fear is that by reducing the activity of nitric oxide synthase, neurons can be protected, but memories can be lost.