What is screening with high permeability?
High throughput screening (HTS) is the process of testing chemical compounds and other substances to observe their interaction with biological materials. Laboratory equipment can test many different samples at the same time to find a reaction to further study. The final goal is to use reactive compounds to discover drugs for various diseases and conditions. In the past, in the past it has been used to detect reactions, but in the 21st century fluorescent techniques and systems are also used. The process also includes machines with higher capacities, so finding new pharmaceutical drugs becomes a faster process.
The process of high transmission is focused on testing procedures called tests that measure how chemicals and medicines interact with organic material. One frequently used test is a scintillation test that uses radiation to monitor the behavior of molecules. Another type, time -respected fluorescence, uses to indicate fluorescent particle molecules and monitor their activity during reactions. FULOrescence polarization detects the rotation of molecules exposed to polarized light, and if less movement occurs, the nature of the reaction can be measured.
work that includes the evaluation of the composition requires skills in different fields. Teaching molecular biology is necessary due to the knowledge needed to understand chemical and biological reactions. It is also necessary to control different types of instrumentation and understanding of the analytical ability of computers. Each process must be fully understood and the researcher must also use his knowledge of the principles for each of them.
different types of tools are used in high permeability screening. Some can do hundreds of thousands of tests every day. These tests sometimes bring useful results; Other times, the results of LIC metabotesting and toxicity help identify compounds for further study. The device includes readers who can detect radioactive or luminescent moleBoots, and test machines that can hold up to hundreds of samples at a time.
The evaluation of the compound is combined with finding a biological goal for screening with high permeability. It can be a specific enzyme, receptor or chemical reaction that occurs in cells. Independent companies are often responsible for testing, while pharmaceutical companies usually work in a partnership with them on drug development. Restricting high permeability screening involves the cost of obtaining materials and equipment. Potential sale of new drugs, as well as licensing materials and practices to other companies, helps make HTC a profitable enterprise.