How Common are Miscarriages?

Repeated miscarriage (or embryo termination) may indicate that the embryo itself may be unhealthy or that the environment of the uterus is not conducive to embryo growth. At present, people are not able to understand all the factors that cause embryos to stop developing, and people can only investigate common factors one by one. The embryo can develop healthy in the womb. It needs the embryo's own health, adequate nutrition, coordination of various hormones, and the avoidance of harmful external factors.

Basic Information

nickname

Embryo cessation

English name

recurrent abortion

Visiting department

Obstetrics and Gynecology

Common causes

Fertilized eggs with abnormal chromosomes, abnormal uterine morphology, endocrine abnormalities, infections, inflammation, etc.

Common symptoms

3 or more consecutive spontaneous abortions

Causes of repeated abortions

1. There are problems with the chromosomes of both spouses or fertilized eggs, which account for about 10% of all embryos aborted.

2. Abnormal uterine morphology is often a factor of repeated abortions, accounting for about 30%.

3. The abnormal endocrine environment is often the culprit of repeated abortions. This includes abnormal luteal development, abnormal thyroid function, abnormal adrenal function (abnormal blood glucose), and abnormal pituitary ovarian hormones.

4. Infectious factors, such as Toxoplasma gondii and rubella virus.

5. Intrauterine adhesions and endometrial inflammation have also received increasing attention.

6. It has been noticed that recurrent abortions often have autoantibodies or alloantibodies, that is, the so-called immune mechanism is disordered, so that the mother rejects embryos containing foreign antigens.

7. What confuses doctors and patients is that despite so many tests, about half of the patients can't find any reason. This shows that people's understanding of embryo termination is still quite limited.

Clinical manifestations of repeated abortions

3 or more consecutive spontaneous abortions.

Repeated abortion check

Routine screening

(1) Analysis of chromosome karyotypes of embryo chromosomes and couples' peripheral blood;

(2) Examination of infection factors;

(3) Complete set of sex hormone, thyroid function and blood glucose measurement;

(4) Ultrasound examination of reproductive organs;

(5) Autoantibody detection.

2. Special immunological etiological examination

(1) Microlymphocyte toxicity test (LCT);

(2) Unidirectional mixed lymphocyte culture (MLC) + inhibition test.

Repeated abortion treatment

1. Repeated miscarriages caused by chromosomal abnormalities

It is the choice of nature. This selection mechanism will eliminate bad embryos and enable human health and high-quality genes to be carried forward and inherited. Because of this factor, repeated abortions cannot be treated. The industry chooses to follow its natural attitude and does not advocate abortion treatment.

2. Repeated abortion caused by abnormal uterine morphology

In some cases it can be corrected by surgery, and in others it cannot be corrected. Repeated abortions due to infection can be treated.

Repeated abortions due to endocrine abnormalities can be regulated.

3. Caused by immune factors

Active immunotherapy with husband's lymphocytes and passive therapy with intravenous gamma globulin have reported effective rates of 70% to 80%.

Repeated abortion prognosis

Repeated miscarriages are still persistent and intractable, but active exploration and treatment can sometimes yield unexpected results. As scientists continue to explore, people will eventually overcome it.