What Is Acute Monocytic Leukemia?

Acute mononuclear leukemia, referred to as acute monoleukemia, belongs to the M5 type in the French-American-British cooperative group classification. It was first described by Scirllling's equal to 1913, so it is also called acute mononuclear leukemia Schilling type.

Acute monocyte leukemia

Acute monocytic leukemia

In the bone marrow or blood smear, the sum of leukemia promonocytes, juvenile monocytes and monocytes is 80%, and the number of neutrophil cells is <20%. AM ₀ L includes two types of acute prokaryotic leukemia and acute mononuclear leukemia. The former is more than 80% of prokaryotic monocytes in leukemia monocytes, which is common in young patients. It is a juvenile monocyte, which is common in adult patients. This line is equivalent to AML-M5 in the original FAB typing. Cytochemical staining NAE-positive sodium fluoride inhibition test positive and NBE-positive were more helpful in identifying monocytes.

A few acute mononuclear leukemias have relatively slow onset and are partly transformed from CMML in MDS. Onset is mainly fatigue, paleness, anorexia, night sweats, weight loss, and more infiltration of organs and tissues.

Leukemia promyeloblasts can express early hematopoietic cell antigens CD34 and CD117, which are positive for HLA-DR in almost all cases; they can also express myeloid markers, and generally express at least two markers of mononuclear differentiation. Protomonocytic leukemia rarely expresses MPO, while monocyte leukemia can be positive for MPO

The onset was mixed. Onset is insidious and gradually progresses within weeks to months, or the onset is rapid. Clinical signs and symptoms from bone marrow failure or

acute

The treatment of acute monocytic leukemia M5 is similar to acute myelogenous leukemia. The general treatment principle is to eliminate the leukemia cell population and control the massive proliferation of leukemia cells, and relieve various clinical manifestations caused by leukemia cell infiltration.