What Is Involved in a Hepatitis B Screening?

Hepatitis B is viral hepatitis type B (viral hepatitis type B). The five items of hepatitis B are also called two and a half of hepatitis B, in order: hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), hepatitis B e antigen (HBeAg), hepatitis B e antibody (anti-HBe), hepatitis B core antibody (anti-HBc). The five tests for hepatitis B are serological markers for detecting hepatitis B virus in the blood. Different combinations of the five items of hepatitis B are commonly used in clinical practice to determine the status and outcome of infection.

Basic Information

Visiting department

Department of Infectious Diseases, Gastroenterology, Laboratory Medicine

Multiple groups

Hepatitis B virus carriers, hepatitis B patients

Common locations

liver

Common causes

Hepatitis B virus

Five contents and significance of two pairs of hepatitis B and half

1.HBsAg (Hepatitis B surface antigen)

It is the shell material of hepatitis B virus, which is not infectious. HBsAg positive often indicates the presence of intact virus particles. HBsAg-positive can usually be detected in the serum 2 to 6 months after the virus infection, before the serum transaminase has risen. Most patients with acute hepatitis B can turn negative early in the course of the disease, but chronic hepatitis B patients will continue to be positive.

2. Anti-HBs (Hepatitis B surface antibody, HbsAb)

Hepatitis B virus (HBV) is naturally occurring in the recovery period of antibodies. At this time, HBsAg has often disappeared naturally. Its existence suggests that people have resistance to hepatitis B, which is an immune and protective antibody against hepatitis B virus in the body. More than 27% of the population in China has this antibody.

3.HBeAg (hepatitis B e antigen)

It is produced inside the virus and can be secreted into the blood. A positive e-antigen indicates that the virus has activity and is an indicator of infectivity. The e antigen is usually positive at the same time as the surface antigen after hepatitis B virus infection, or a few days later.

4. Anti-HBe (Hepatitis B e antibody, HBeAb)

It is a protein produced by the human body against the e antigen. The positive result indicates that the infectivity of the virus has weakened, and the disease is in the recovery stage. The e antibody positive appears several months after the antigen becomes negative. However, another situation may be that the hepatitis B virus has been mutated. At this time, there is no HBeAg in the serum, but anti-HBe can be produced. In this case, HBV-DNA needs to be checked to determine whether there is still the virus.

5. Anti-HBc (Hepatitis B core antibody, HbcAb)

Hepatitis B core antibodies are divided into two types: IgM and lgG: anti-HBc-IgM positive indicates virus activity and infectious; anti-HBc-IgG positive indicates previous infection, non-infectious, and does not require antiviral treatment. Core antibodies are usually detected in serum 3 to 5 weeks after the appearance of surface antigens, and before the onset of hepatitis B symptoms.

In addition, HBV-DNA is the genetic gene of the virus and exists in the core of the virus. Its positive and HBeAg positive meanings are basically the same. Therefore, the effectiveness of the currently recognized antiviral therapy is mainly based on the significant reduction in negative conversion or quantification of HBeAg and HBV-DNA.

Hepatitis B two-and-a-half hepatitis B checklist content

1. Hepatitis B is positive for item 1, and the remaining four items are negative, indicating that it is the late incubation period of acute viral infection.

2. Hepatitis B is positive for items 1, 3, and 5, and the remaining two are negative, commonly known as hepatitis B. The three positives indicate that it is acute and chronic hepatitis B, which is relatively infectious.

3. Hepatitis B is positive for items 1, 4, 5 and the other two are negative, commonly known as hepatitis B small three positives, indicating acute and chronic hepatitis B and relatively weak infectivity.

4. Hepatitis B is positive for items 1 and 3, and the remaining three are negative. This is the early stage of acute hepatitis B.

5. Hepatitis B five items 1, 3, 4, 5 are positive, indicating that acute hepatitis B infection tends to recover, or chronic hepatitis B virus carriers.

6. Hepatitis B is positive for items 1 and 4 and the remaining three are negative, indicating that carriers of chronic hepatitis B surface antigen are likely to become negative, or that acute infection tends to recover.

7. Hepatitis B is positive for items 1, 5 and the other three are negative, indicating acute and chronic hepatitis B, namely: acute HBV infection; chronic HBsAg carriers; weak infectivity.

8. Hepatitis B is positive for item 5 and the remaining four items are negative, indicating that: anti-HBs could not be detected in previous infections; HBsAg has disappeared during the recovery period, and anti-HBs has not yet appeared;

9. Hepatitis B is positive for items 2, 4, and 5, and the other two are negative, indicating that it is the recovery period of hepatitis B and that it has immunity.

10. Hepatitis B is positive for item 2 and the remaining four items are negative, indicating that: Hepatitis B vaccine has been injected and antibodies have been produced, and immunity; Hepatitis B virus infection has occurred, and there is a certain degree of immunity; False Positive.

11. Hepatitis B is positive for items 2 and 5 and the remaining three items are negative, indicating that he has recovered from the hepatitis B vaccine or has recovered from the hepatitis B virus infection.

12. Hepatitis B is positive for items 4 and 5 and the remaining three are negative, indicating that it is the recovery period of acute hepatitis B virus infection, or has been infected with the virus.

13. Hepatitis B five total negative, indicating that HBV has not been infected in the past and present, but there is no protective antibody.