What Is Tetanus Immunoglobulin?

Tetanus immunoglobulin is made by collecting high titer plasma or serum from healthy blood donors who have been immunized with hepatitis B vaccine and then immunized with tetanus toxoid. It is mainly used to prevent and treat tetanus, especially for tetanus. Allergic reactions to antitoxin (TAT). It is suitable for tetanus patients with unclear immunization history and serum allergies, wound infection for more than 24 hours, and tetanus toxoid inoculation.

Tetanus immunoglobulin

Tetanus immunoglobulin is made by collecting high titer plasma or serum from healthy blood donors immunized with hepatitis B vaccine and then immunized with tetanus toxoid. It is mainly used to prevent and treat tetanus, especially for tetanus.

It is mainly used to prevent and treat infections caused by Clostridium tetanus, especially for those who are allergic to tetanus antitoxin (TAT).

Plasma collected from the vaccinated tetanus vaccine was automatically immunized to healthy blood donors according to the nationally approved immunization program. Each batch should be mixed with the plasma of at least 100 immune donors, and the tetanus antibody titer of the combined plasma should not be less than 8 IU per 1ml.

The immunoglobulin components are extracted by fractional precipitation using a low-temperature ethanol protein separation method, and are obtained through processes such as ultrafiltration or freeze-drying, dealcoholization, concentration, and virus inactivation. The purity of the immunoglobulin should be greater than 90%. It is then formulated into a solution of tetanus antibody titer of not less than 100 international units per 1ml, adding an appropriate amount of stabilizer, sterilizing and filtering, and aseptic filling.

Preventive dose: 250IU for children and adults. For serious wounds or serious contamination, double the dose.

Therapeutic dose: The recommended dose is 3000-10000IU.

The lyophilized preparation is dissolved with sterile water for injection, and an appropriate amount of solution is added to dissolve according to the IU number indicated on the bottle label. All operations such as dissolution and injection should be carried out according to strict disinfection procedures. This product is limited to intramuscular injection of the buttocks, no skin test is required, and no intravenous injection is allowed.

1. While applying this product for passive immunization, you can use the adsorption tetanus vaccine for automatic immunization, but the injection site and equipment should be separated.

2. The product should be clear or opalescent liquid, trace precipitation may occur, but it should dissipate immediately after shaking. Do not use if there is unshakable sediment or foreign matter, and if the glass is cracked or expired.

3. After opening the bottle, the product should be used in one injection and not used for several times.

4. This product is a human blood product. Although it has been screened and inactivated by virus, it still cannot completely exclude the possibility of transmission of blood-borne diseases caused by unknown pathogens such as viruses.

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1. The lyophilized preparation should be clear or milky liquid after reconstitution. Do not use if there is unshakable precipitation or foreign matter. The liquid preparation may show a slight precipitation for a long time, but it should dissipate immediately after shaking.

2 . After the ampoule is opened, the product should be used in one injection and not used for several times.

The specification is that the titer of tetanus antibody is not less than 100IU / m1, 250IU per dose.