Toxicity data from literature and journals Numbering | Toxicity type | testing method | Test object | Dosage used | Toxic effect |
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1 | Acute toxicity | oral | Humanity | 714 mg / kg | 1. Cerebral toxicity-other degenerative changes 2. Behavioral toxicity-convulsions or seizure thresholds affected 3. Gastrointestinal toxicity-nausea, vomiting |
2 | Acute toxicity | Intravenous injection | Adult male | 71 mg / kg | 1. Hepatotoxicity-Hepatitis (hepatocyte necrosis), spread 2. Hematological toxicity-Orthocytic anemia 3. Biochemical toxicity-Other changes in metabolism |
3 | Acute toxicity | Intraperitoneal injection | Rat | 150 mg / kg | Detailed effects are not reported other than lethal dose |
4 | Acute toxicity | Intraperitoneal injection | Mouse | 140 mg / kg | Detailed effects are not reported other than lethal dose |
5 | Acute toxicity | Intravenous injection | Mouse | 104 mg / kg | 1. Nutritional and metabolic system toxicity-weight loss or weight loss rate |
6 | Acute toxicity | oral | dog | 300 mg / kg | Detailed effects are not reported other than lethal dose |
7 | Acute toxicity | Subcutaneous injection | dog | 80 mg / kg | Detailed effects are not reported other than lethal dose |
8 | Acute toxicity | Intravenous injection | dog | 300 mg / kg | Detailed effects are not reported other than lethal dose |
9 | Acute toxicity | Subcutaneous injection | Cat | 100 mg / kg | Detailed effects are not reported other than lethal dose |
10 | Acute toxicity | Subcutaneous injection | rabbit | 300 mg / kg | Detailed effects are not reported other than lethal dose |
11 | Acute toxicity | Intravenous injection | rabbit | 25 mg / kg | 1. Behavioral toxicity-affected by convulsions or seizure thresholds 2. Behavioral toxicity-affected food intake (animals) 3. Gastrointestinal toxicity-excessive exercise, diarrhea |
12 | Acute toxicity | Intraperitoneal injection | pigeon | 150 mg / kg | Detailed effects are not reported other than lethal dose |
13 | Acute toxicity | Subcutaneous injection | frog | 1600 mg / kg | Detailed effects are not reported other than lethal dose |
14 | Chronic toxicity | oral | Rat | 240 mg / kg / 17W-I | 1. Liver toxicity-other changes 2. Kidney, ureter and bladder toxicity-other changes 3. Biochemical toxicity-Inhibition or induction of dehydrogenase |
15 | Chronic toxicity | oral | Rat | 122 mg / kg / 90D-C | 1. Cardiotoxicity-changes in electrocardiogram 2. Vascular toxicity-increased blood pressure without autonomic ganglia 3. Nutritional and metabolic system toxicity-changes in calcium concentration |
16 | Chronic toxicity | oral | Rat | 2006 mg / kg / 61W-C | 1. Cerebral toxicity-other degenerative changes 2. Vascular toxicity-increased blood pressure without autonomic ganglia 3. Nutrition and metabolic system toxicity-changes in metal ion concentration |
17 | Chronic toxicity | oral | Rat | 43 mg / kg / 1.5YC | 1. Kidney, ureter and bladder toxicity-other changes 2. Hematological toxicity-changes in serum composition (such as TP, bilirubin, cholesterol) |
18 | Chronic toxicity | oral | Rat | 923 mg / kg / 28W-C | 1. Peripheral neurotoxicity-sensory changes 2. Peripheral neurotoxicity-peripheral nervous system abnormalities 3. Nutrition and metabolic system toxicity-weight loss or rate of weight loss |
19 | Chronic toxicity | oral | Rat | 192 mg / kg / 5W-C | 1. Hematological toxicity-changes in red blood cell counts 2. Nutrition and metabolic system toxicity-weight loss or weight gain rate reduction 3. Biochemical toxicity-inhibition of transaminase activity and changes in the spatial structure of transaminase |
20 | Chronic toxicity | oral | Rat | 126 mg / kg / 30W-C | 1. Kidney, ureter and bladder toxicity-changes in bladder weight 2. Endocrine toxicity-hypoglycemia |
twenty one | Chronic toxicity | oral | Rat | 344 mg / kg / 1Y-C | 1. Brain toxicity-other degenerative changes 2. Brain toxicity-Changes in brain weight 3. Nutrition and metabolic system toxicity-Weight loss or rate of weight loss |
twenty two | Chronic toxicity | oral | Rat | 2907 mg / kg / 36W-C | 1. Kidney, ureter and bladder toxicity-other changes 2. Kidney, ureter and bladder toxicity-changes in bladder weight 3. Endocrine toxicity-changes in spleen weight |
twenty three | Chronic toxicity | Intraperitoneal injection | Rat | 59 mg / kg / 6W-I | 1. Gastrointestinal toxicity-other changes 2. Nutrition and metabolic system toxicity-changes in sodium concentration 3. Biochemical toxicity-inhibition or induction of phosphatase |
twenty four | Chronic toxicity | oral | Rat | 4404 mg / kg / 8W-I | 1. Cerebral toxicity-other degenerative changes 2. Biochemical toxicity-Inhibition or induction of cholinesterase 3. Biochemical toxicity-Metabolism and abnormal blood transport |
25 | Chronic toxicity | Subcutaneous injection | Rat | 450 mg / kg / 6W-I | 1. Hematological toxicity-Orthocytic anemia 2. Biochemical toxicity-Inhibition of other hydrolases 3. Biochemical toxicity-Affects porphyrins, including bile pigments |
26 | Chronic toxicity | Subcutaneous injection | Rat | 1920 mg / kg / 14W-I | 1. Hematological toxicity-abnormal staining of red blood cells or affecting nucleated red blood cells 2. Hematological toxicity-appearance of methemoglobin, carboxyhemoglobin 3. Hematological toxicity-changes in red blood cell count |
27 | Chronic toxicity | Intraperitoneal injection | Rat | 30 mg / kg / 30D-I | 1. Hematological toxicity-other changes 2. Nutritional and metabolic system toxicity-weight loss or rate of weight gain reduction 3. Chronic disease-related toxicity-changes in testicular weight |
28 | Chronic toxicity | Intraperitoneal injection | Rat | 152 mg / kg / 4D-I | 1. Brain toxicity-changes in EEG 2. Hematological toxicity-other changes 3. Nutrition and metabolic system toxicity-Weight loss or rate of weight loss |
29 | Chronic toxicity | Intraperitoneal injection | Rat | 69 mg / kg / 22W-I | 1. Peripheral neurotoxicity-abnormal afferent nerve 2. Peripheral neurotoxicity-abnormal peripheral nervous system 3. Kidney, ureter and bladder toxicity-changes in urine components |
30 | Chronic toxicity | oral | Mouse | 1120 mg / kg / 16W-I | 1. Cerebral toxicity-other degenerative changes 2. Cerebral toxicity-changes in brain weight 3. Biochemical toxicity-other proteins |
31 | Chronic toxicity | oral | Mouse | 880 mg / kg / 14D-C | 1. Kidney, ureter and bladder toxicity-changes in urine components 2. Biochemical toxicity-Inhibition of other hydrolytic enzymes 3. Biochemical toxicity-Inhibition or induction of other enzymes |
32 | Chronic toxicity | oral | Mouse | 11087 mg / kg / 26W-C | 1. Hematological toxicity-other changes 2. Biochemical toxicity-inhibition or induction of other enzymes |
33 | Chronic toxicity | oral | Mouse | 4710 mg / kg / 30D-C | 1. Hematological toxicity-other changes 2. Hematological toxicity-changes in bone marrow 3. Biochemical toxicity-inhibition of other hydrolases |
34 | Chronic toxicity | Intraperitoneal injection | Mouse | 37680 ug / kg / 5D-I | 1. Kidney, ureter and bladder toxicity-other changes 2. Hematological toxicity-other changes 3. Nutrition and metabolic system toxicity-changes in metal ion concentration |
35 | Chronic toxicity | oral | dog | 286 mg / kg / 13W-I | 1. Kidney, ureter and bladder toxicity-changes in urine components 2. Hematological toxicity-other changes 3. Biochemical toxicity-inhibition or induction of other enzymes |
36 | Chronic toxicity | Subcutaneous injection | rabbit | 117 mg / kg / 33W-I | 1. Hematological toxicity-Orthocytic anemia 2. Hematological toxicity-Other changes |
37 | Chronic toxicity | oral | pigeon | 4396 mg / kg / 64W-I | 1. Kidney, ureter and bladder toxicity-changes in renal tubules (including acute renal failure, acute tubular necrosis) 2. Hematological toxicity-Orthocytic anemia 3. Hematological toxicity-Other changes |
38 | Chronic toxicity | oral | Domestic mammal | 105 mg / kg / 7D-I | 1. Cerebral toxicity-affects the central nervous system in specific areas 2. Eye toxicity-not reported 3. Biochemical toxicity-affects glycolysis |
39 | Mutation toxicity | | Escherichia coli | 50 umol / L | |
40 | Mutation toxicity | | Saccharomyces cerevisiae | 250 umol / L | |
41 | Mutation toxicity | | Human lymphocyte | 1 mmol / L / 24H | |
42 | Mutation toxicity | Intraperitoneal injection | Rat | 51800 ug / kg | |
43 | Mutation toxicity | | Rat embryo | 200 mg / L | |
44 | Mutation toxicity | Intraperitoneal injection | Rat | 50 ug / kg | |
45 | Mutation toxicity | Parenteral | Rat | 5 mg / kg | |
46 | Mutation toxicity | Intraperitoneal injection | Rat | 10400 ug / kg | |
47 | Mutation toxicity | oral | Rat | 5000 ppm | |
48 | Mutation toxicity | Not reported | Rat | 9 mg / kg / 26W (continuous) | |
49 | Mutation toxicity | Intraperitoneal injection | Rat | 51800 ug / kg | |
50 | Mutation toxicity | Not reported | Rat | 1825 ug / kg / 1Y (continuous) | |
51 | Mutation toxicity | Intraperitoneal injection | Mouse | 7500 ug / kg | |
52 | Mutation toxicity | | Mouse fibroblast | 800 ug / L | |
53 | Mutation toxicity | oral | Mouse | 16800 mg / kg / 4W | |
54 | Mutation toxicity | Intraperitoneal injection | Mouse | 100 mg / kg | |
55 | Mutation toxicity | oral | Mouse | 19200 mg / kg / 48D | |
56 | Mutation toxicity | Intraperitoneal injection | Mouse | 179 ug / kg | |
57 | Mutation toxicity | Parenteral | Mouse | 1 mg / kg | |
58 | Mutation toxicity | Intraperitoneal injection | Mouse | 400 mg / kg / 5D (intermittent) | |
59 | Mutation toxicity | | Hamster embryo | 1 mg / L | |
60 | Mutation toxicity | | Hamster lung | 1700 umol / L | |
61 | Mutation toxicity | | Hamster embryo | 200 umol / L | |
62 | Mutation toxicity | | Hamster lung | 1700 umol / L | |
63 | Mutation toxicity | oral | monkey | 206 mg / kg / 64W (intermittent) | |
64 | Mutation toxicity | oral | Domestic mammal | 364 mg / kg / 52W (continuous) | |
65 | Mutation toxicity | Testicle injection | Domestic mammal | 10 mg / kg | |
66 | Carcinogenicity | oral | Rat | 900 mg / kg / 60D-C | 1. Carcinogenicity-tumor (according to RTECS standards) 2. Lung, chest or respiratory toxicity-tumor 3. Endocrine toxicity-adrenal tumor |
67 | Carcinogenicity | oral | Rat | 250 mg / kg / 47W-C | 1. Carcinogenicity-may be carcinogenic (according to RTECS standards) 2. Kidney, ureter and bladder toxicity-kidney tumors |
68 | Carcinogenicity | oral | Rat | 2430 mg / kg / 23W-C | 1. Carcinogenicity-may be carcinogenic (according to RTECS standards) 2. Brain toxicity-tumor 3. Endocrine toxicity-tumor |
69 | Carcinogenicity | oral | Rat | 4605 mg / kg / 44W-C | 1. Carcinogenicity-may be carcinogenic (according to RTECS standards) 2. Lung, chest or respiratory toxicity-tumor 3. Endocrine toxicity-adrenal tumor |
70 | Carcinogenicity | oral | Rat | 7560 mg / kg / 72W-C | 1. Carcinogenicity-tumor (according to RTECS standards) 2. Endocrine toxicity-tumor 3. Endocrine toxicity-thyroid tumor |
71 | Carcinogenicity | oral | Rat | 9150 mg / kg / 44W-C | 1. Carcinogenicity-tumor (according to RTECS standards) 2. Kidney, ureter and bladder toxicity-kidney tumors |
72 | Carcinogenicity | oral | Rat | 218 mg / kg / 1Y-C | 1. Carcinogenicity-may be carcinogenic (according to RTECS standards) 2. Kidney, ureter and bladder toxicity-kidney tumors |
73 | Carcinogenicity | oral | Rat | 138 mg / kg / 76W-C | 1. Carcinogenicity-may be carcinogenic (according to RTECS standards) 2. Kidney, ureter and bladder toxicity-kidney tumors |
74 | Reproductive toxicity | oral | Rat | 1257 uL / kg, female 10 days before conception | 1. Reproductive toxicity-affects the mother's body 2. Reproductive toxicity-abnormal development of blood and lymphatic system (including spleen and bone marrow) 3. Reproductive toxicity-other developmental abnormalities |
75 | Reproductive toxicity | oral | Rat | 600 ug / kg, male mating 30 days ago | 1. Reproductive toxicity-abnormal male spermatogenesis (including genetic material, sperm morphology, sperm motility and count) 2. Reproductive toxicity-changes in prostate, seminal vesicles, Cobb's glands, and accessory glands 3. Reproductive toxicity-impotence |
76 | Reproductive toxicity | oral | Rat | 97 mg / kg, male mating 5 weeks ago | 1. Reproductive toxicity-affecting the behavior of newborns |
77 | Reproductive toxicity | oral | Rat | 14700 mg / kg, 1 to 21 days after conception | 1. Reproductive toxicity-affect the live birth index of newborn 2. Reproductive toxicity-other changes 3. Reproductive toxicity-decrease in newborn weight gain |
78 | Reproductive toxicity | oral | Rat | 1800 mg / kg, 1 to 22 days after conception | 1. Reproductive toxicity-affecting the biochemistry and metabolism of the newborn |
79 | Reproductive toxicity | oral | Rat | 460 mg / kg, 49 days before female conception | 1. Reproductive toxicity-reduced weight gain in newborns |
80 | Reproductive toxicity | oral | Rat | 230 mg / kg, 49 days before female conception | 1. Reproductive toxicity-abnormal development of blood and lymphatic system (including spleen and bone marrow) 2. Reproductive toxicity-has other effects on newborns |
81 | Reproductive toxicity | oral | Rat | 1950 mg / kg, 6-18 days after conception | 1. Reproductive toxicity-increased mortality after implantation |
82 | Reproductive toxicity | oral | Rat | 1413 mg / kg, 1-18 days after female conception | 1. Reproductive toxicity-affects mother-to-child communication 2. Reproductive toxicity-fetal toxicity (such as fetal dysplasia but not death) |
83 | Reproductive toxicity | Intraperitoneal injection | Rat | 25 mg / kg, 9 days after conception | 1. Reproductive toxicity-increased mortality after implantation 2. Reproductive toxicity-embryo or fetal death 3. Reproductive toxicity-ear / eye developmental abnormalities |
84 | Reproductive toxicity | Intraperitoneal injection | Rat | 120 mg / kg, male mating 30 days ago | 1. Reproductive toxicity-changes in testis, epididymis, and vas deferens 2. Reproductive toxicity-changes in prostate, seminal vesicles, Cobb's glands, and accessory glands |
85 | Reproductive toxicity | Intraperitoneal injection | Rat | 60 mg / kg, 13-19 days after female conception | 1. Reproductive toxicity-affects the fetus |
86 | Reproductive toxicity | Intraperitoneal injection | Rat | 1256 mg / kg, male mating 14 weeks ago | 1. Reproductive toxicity-abnormal male spermatogenesis (including genetic material, sperm morphology, sperm motility and count) 2. Reproductive toxicity-changes in testis, epididymis, and vas deferens |
87 | Reproductive toxicity | oral | Rat | 2380 mg / kg, male mating 17 weeks ago | 1. Reproductive toxicity-abnormal male spermatogenesis (including genetic material, sperm morphology, sperm motility and count) 2. Reproductive toxicity-late birth |
88 | Reproductive toxicity | oral | Mouse | 236 mg / kg, 7-16 days after conception | 1. Reproductive toxicity-fetal toxicity (such as fetal dysplasia but not death) |
89 | Reproductive toxicity | oral | Mouse | 4800 mg / kg, 1-8 days after conception | 1. Reproductive toxicity-increased pre-implantation mortality |
90 | Reproductive toxicity | oral | Mouse | 9 mg / kg, 7-21 days after conception | 1. Reproductive toxicity-abortion |
91 | Reproductive toxicity | oral | Mouse | 259 mg / kg, 7-17 days after conception | 1. Reproductive toxicity-abnormal development of blood and lymphatic system (including spleen and bone marrow) |
92 | Reproductive toxicity | Intraperitoneal injection | Mouse | 35 mg / kg, 8 days after female conception | 1. Reproductive toxicity-fetal toxicity (such as fetal dysplasia but not death) 2. Reproductive toxicity-embryo or fetal death 3. Reproductive toxicity-abnormal development of the musculoskeletal system |
93 | Reproductive toxicity | Intraperitoneal injection | Mouse | 180 mg / kg, 10-16 days after conception | 1. Reproductive toxicity-abnormal ear / eye development 2. Reproductive toxicity-Reduced weight gain in the newborn 3. Reproductive toxicity-affects the behavior of the newborn |
94 | Reproductive toxicity | Intravenous injection | Mouse | 100 mg / kg, 11 days after female conception | 1. Reproductive toxicity-fetal toxicity (such as fetal dysplasia but not death) 2. Reproductive toxicity-embryo or fetal death 3. Reproductive toxicity-abnormalities of the skull and face (including nose / tongue) |
95 | Reproductive toxicity | Intravenous injection | Mouse | 200 mg / kg, 7-8 days after conception | 1. Reproductive toxicity-increased mortality after implantation |
96 | Reproductive toxicity | oral | monkey | 765 mg / kg, 90 days before female conception | 1. Reproductive toxicity-affecting the behavior of newborns |
97 | Reproductive toxicity | oral | monkey | 1557 mg / kg, female pregnant 62 weeks ago | 1. Reproductive toxicity-affects newborns |
98 | Reproductive toxicity | oral | monkey | 600 mg / kg, female 57 weeks before conception | 1. Reproductive toxicity-affects the mother 2. Endocrine toxicity-changes in luteinizing hormone |
99 | Reproductive toxicity | Subcutaneous injection | Rat | 110 mg / kg, male mating 15 weeks ago | 1. Reproductive toxicity-affects the behavior of the newborn 2. Reproductive toxicity-has other effects on the newborn |
100 | Reproductive toxicity | oral | Guinea Pig | 300 mg / kg, 22-52 days after female conception | 1. Reproductive toxicity-affects the mother 2. Reproductive toxicity-abnormal development of the central nervous system 3. Reproductive toxicity-abnormal development of blood and lymphatic system (including spleen and bone marrow) |
101 | Reproductive toxicity | oral | Guinea Pig | 1108 mg / kg, 22-52 days after female conception | 1. Reproductive toxicity-affects the mother 2. Reproductive toxicity-abnormal development of the endocrine system |
102 | Reproductive toxicity | Intraperitoneal injection | Guinea Pig | 12500 ug / kg, 20 days after female conception | 1. Reproductive toxicity-abnormal development of the central nervous system |
103 | Reproductive toxicity | Intravenous injection | Hamster | 50 mg / kg, 8 days after female conception | 1. Reproductive toxicity-abnormal development of the musculoskeletal system 2. Reproductive toxicity-abnormal development of the central nervous system 3. Reproductive toxicity-abnormal ear / eye development |
104 | Reproductive toxicity | Intravenous injection | Hamster | 25 mg / kg, 8 days after conception | 1. Reproductive toxicity-increased mortality after implantation 2. Reproductive toxicity-abnormal development of the musculoskeletal system |
105 | Reproductive toxicity | Testicle injection | Domestic mammal | 10 mg / kg, male mated 1 day ago | 1. Reproductive toxicity-abnormal male spermatogenesis (including genetic material, sperm morphology, sperm motility and count) 2. Reproductive toxicity-changes in testis, epididymis, and vas deferens |
106 | Reproductive toxicity | Intravenous injection | mammal | 256 mg / kg, 7-10 days after conception | 1. Reproductive toxicity-increased mortality after implantation |