What Is Buffered Lidocaine?

The compound chamomile lidocaine gel is suitable for inflammatory pain of gums, lips and oral mucosa. 2. It can alleviate the local symptoms during the eruption of deciduous teeth and wisdom teeth and the local symptoms caused by wearing orthodontic appliances. 3. It can be used as an adjuvant treatment for pain and discomfort and irritating and / or allergic reactions that occur after wearing dentures.

The compound chamomile lidocaine gel is suitable for inflammatory pain of gums, lips and oral mucosa. 2. It can alleviate the local symptoms during the eruption of deciduous teeth and wisdom teeth and the local symptoms caused by wearing orthodontic appliances. 3. It can be used as an adjuvant treatment for pain and discomfort and irritating and / or allergic reactions that occur after wearing dentures.

Drug Name

Compound chamomile lidocaine gel

Drug type

prescription

Compound chamomile lidocaine gel ingredients

This product is a compound preparation, and its components are as follows:
Dolicaine hydrochloride 20 mg thymol 1 mg chamomile chrysanthemum (1: 5.5) 200 mg Other ingredients are: benzalkonium chloride, polyacrylic acid, sodium saccharin, azatriol, cinnamon oil

Compound chamomile lidocaine gel traits

This product is a brown-yellow uniform gel.

Compound chamomile lidocaine gel indication

1. For inflammatory pain of gums, lips and oral mucosa.
2. It can alleviate the local symptoms during the eruption of deciduous teeth and wisdom teeth and the local symptoms caused by wearing orthodontic appliance
3. It can be used as an adjuvant treatment for the pain and discomfort and irritating and / or allergic reactions after wearing dentures.

Compound chamomile lidocaine gel specifications

10g (each 10g contains 200mg lidoca hydrochloride, 10mg thymol, 2g chamomile flower tincture)

Compound chamomile lidocaine gel usage dosage

1, inflammatory pain in the gums or oral mucosa.
Apply the gel about 0.5 cm 3 times a day to the painful or inflamed gum area and massage a little.
2. Treatment of symptoms or lesions related to wearing dentures:
Massage the affected area with a pea-sized gel.

Compound chamomile lidocaine gel adverse reactions

This product generally has no adverse reactions, but it may be absorbed in special areas when used in large doses. For example, a 11-month-old child used a 2% lidocaine solution in the painful area due to tooth eruption. One week after using 6 times the daily recommended dose, the child's lidocaine blood concentration was 10 ug / Convulsions occur in mL, usually with a blood concentration above 6 ug / mL, which is prone to toxic symptoms, and it is unknown whether children accidentally swallow lidocaine solution. Therefore, this product is only used in older children to ease the discomfort of permanent tooth eruption, and accidental swallowing should be avoided.
Lidocaine can trigger late-onset and rapid-onset allergies. It can cross-allergic with other amide drugs. Frequent local use of lidocaine, especially for mucosa, can trigger allergies.

Compound chamomile lidocaine gel contraindicated

This product is contraindicated in patients with known allergic reactions to various ingredients in Gamiida gel.

Notes on compound chamomile lidocaine gel

Keep this product out of the reach of children.

Compound chamomile lidocaine gel for pregnant and lactating women

No relevant information yet.

Compound chamomile lidocaine gel for children

This product can be used to relieve the discomfort caused by teething in young children or school-age children, but the length of each gel should not exceed 0.5 cm, and should not exceed 3 times in 24 hours. When the gel is used in large doses, especially when the lidocaine plasma concentration is greater than 6 ug / mL, a toxic reaction may occur. The gel is more suitable for older children to prevent accidental swallowing.

Compound chamomile lidocaine gel for the elderly

No relevant information yet.

Compound chamomile lidocaine gel drug interaction

No interactions between the components in Gumida gel or adverse interactions with other drugs have been reported.

Compound chamomile lidocaine gel overdose

For different symptoms, take appropriate symptomatic treatment.

Compound chamomile lidocaine gel pharmacology and toxicology

I. Pharmacological effect This product is a topical medicine for local application. <br /> Gammeida is a hydrosol preparation for oral mucosa and inflammation or damaged skin. It is a compound preparation, which has quick and long-lasting analgesic, antibacterial, anti-inflammatory and promoting wound healing for inflammatory diseases of oral mucosa and skin.
1. Lidocaine HCL
Local anesthesia / analgesic effect is achieved by blocking the generation and conduction of nerve impulses. The intensity of action is higher than procaine, and it is one of the most commonly used epidermal / mucosal local anesthetics in clinical practice.
Some research reports show that lidocaine can inhibit the growth of Neisseria meningitidis and Neisseria gonorrhoeae at low concentrations. At high concentrations, it can kill E. coli and group A streptococci.
2. Thymol: It is a phenol derivative and a disinfectant and antiseptic. It is effective against a variety of bacteria, fungi, and viruses. Its bactericidal ability is 30 times that of phenol, and its toxicity is only 1/4 of the latter. In dentistry or laryngology, thymol is also often used as an active ingredient to formulate disinfecting mouthwashes.
3. Chamomile tincture: Chamomile flower (also known as mother chamomile, German chamomile) is a supplementary active ingredient in this gel.
In a rat paw edema model induced by carrageenan, the anti-edema effect of chamomile flower extract is comparable to salicylic acid. Experimental data show that chamomile flower extract can reduce arachidonic acid production and inhibit cyclooxygenase activity, thereby reducing prostaglandin production; it has antihistamine and inflammatory mediator activity. In addition, chamomile flower extract also has the effect of scavenging oxygen free radicals.
The chamomile flower extract at a concentration of 10 mg / mL has an inhibitory effect on a variety of bacteria, and is particularly sensitive to S. aureus, a common oral pathogen.
The medicine and its extract have various effects such as anti-inflammatory, antispasmodic, promoting wound healing, antibacterial and promoting skin metabolism.
4. Benzalkonium Chloride
As a cationic surfactant, benzalkonium chloride can destroy bacterial enzymes and is effective against common pathogens such as Staphylococcus aureus, Streptococcus, Escherichia coli, Streptococcus mutans, Klebsiella, and Pseudomonas aeruginosa; Fungi such as Candida albicans also have a role.
Toxicology test:
1. Lidocaine HCL
The content in Ganda Gel is 20 mg / g. Tests have confirmed that lidocaine is a safe dosage for topical oral application and use in Ganmeida gel.
Oral acute toxicity mouse LD ₅₀ 220 mg / kg
The minimum toxic dose of intravenous acute poisoning in humans (male) is 14 mg / kg
Rat LD50 21 mg / kg
Mouse LD50 22 mg / kg.
Unless used on a large area of the skin / mucosa, lidocaine hydrochloride is generally free of systemic toxicity. Due to individual tolerance, age, gender, general health status, and tissue vascularization, there are large individual differences in human toxicity. When the lidocaine concentration in the plasma is 5 ug / mL, it can cause muscle tremors, convulsions, and respiratory arrest. Lidocaine is easily absorbed, but the dose in Ganmeda gel is only one-fifth of the therapeutic dose in nude mouse plasma. Clinical trials confirm that lidocaine is a safe topical analgesic.
2. Thymol: The content in the gel is 1.0 mg / g. The drug has very low toxicity. Its toxicity is only 1/4 of that of phenol.
Oral acute poison rat LD50 980 mg / kg
Mouse LD50 1800 mg / kg
Guinea pig LD50 880 mg / kg.
Intravenous acute poisoning mice LD50 74 mg / kg.
Chronic toxicity rats received 10,000 PPM daily for 19 weeks without toxicity.
The human body takes 1 g of thymol orally, and there is no obvious adverse reaction, and there is only a burning sensation in the stomach. When the dose is more than 1 g, it can cause gastrointestinal discomfort, fatigue, sweating, decreased heart rate, and collapse.
3. Chamomile tincture
The content of Gummy Gel is 200 mg / g.
The Pharmacopoeia (Chamomile Flower Master Monograph, Bundesanzeiger, Federal Gazette of Germany No. 228) details that no toxic reaction has been found to occur. Toxicity data show that this product and its ingredients have a high therapeutic index.
Acute toxicity:
Lyophilized chamomile flower extract mice nontoxic 1440 mg / kg
-bisabolol (Myrrhol) causing adverse reactions Minimum dose for mice 6.35 mg / kg
Rat oral 6.35 mg / kg
Dog 15.9 mg / kg
Monkey (Rhesus monkey) 0.5 mg / kg.
Subacute toxicity:
(-bisabolol) 6 weeks non-toxic to rats 1.0 mg / kg
Rat 4 weeks early symptoms 2.0 mg / kg
Beagle dogs have no toxicity of 1.0 mg / kg for 2 weeks.
4. Benzalkonium Chloride: The content in Ganda Gel is 1.0 mg / g. The drug is low-toxic.
Oral acute rat LD50 450-750 mg / kg
Mouse LD50 300 mg / kg.
Intravenous acute poisoning in mice with LD50 20 mg / kg.
Subacute toxicity: Rats daily oral dose of 550 ppm × 3 months without toxicity.
Other results of skin irritation, sensitivity tests, accumulation tests, chronic toxicity tests and mutagenicity tests performed on animals and humans have shown its safety. 0.1% of benzalkonium chloride does not cause sensitization in humans and animals.
summary:
Toxicological tests show that the active ingredients of this gel are not particularly dangerous. No adverse interactions were observed when the active ingredients in this product were combined. Alpha-Bisabolol facilitates penetration of other active ingredients. However, it has not been proven whether this effect includes lidocaine, and no adverse interaction with other drugs has been seen during external use.

Pharmacokinetics of Compound Chamomile Lidocaine Gel

Ganmeida gel is a hydrogel preparation for (oral) mucosa and inflammation or damage to the skin. The pharmacokinetic data of various active ingredients are as follows:
1. Lidocaine HCL
When the concentration is 0.5-4%, it is effective for skin with lack of immunity, and its effect is to buffer the skin by forming a free matrix on the skin surface. As a result of the concentration gradient, the free matrix can quickly diffuse into the deep layers of the skin and enter the capillary network.
The 2% lidocaine solution has been used for bronchoscopy. The local concentration of lidocaine in the tissue can be measured from the biopsy is 0.05-1.19%. The author emphasizes that within this concentration range, lidocaine in the tissue has a clear Antibacterial activity.
Lidocaine absorbed throughout the body is metabolically inactivated in the liver.
2. Thymol
When thymol is applied topically, its absorption is very limited, and a small amount of absorbent is completely biotransformed by the body. Combined with sulfate or glucuronic acid, excreted from urine.
3. Chamomile tincture:
A single dose of topical 6 mg [ ¹⁴ C] -bisabolol (the main active ingredient in chamomile) was applied to the skin of the neck of female nude mice. 75% of the markers reached 120 mcm in depth after 1 hour and 5 hours later. 50% of the markers were obtained to a skin depth of 90-180 mcm. It suggests that the medicine has a constant penetrating power to the skin.
4. Benzalkonium Chloride:
The concentration of 0.1% can exert its antiseptic effect in the gel.

Compound chamomile lidocaine gel storage

Keep away from light, keep in a tightly closed place, and keep it at a temperature not higher than 25 ° C. Keep this product out of the reach of children.

Compound chamomile lidocaine gel pack

Aluminum tube packaging

Compound chamomile lidocaine gel expiration date

3 years ^[1]