What is nimesulide?

Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) designed to inhibit the enzyme COX-2. It is generally used as analgesic and antipyretic, which means that it treats acute pain and anxiety. In addition to therapeutic properties, however, it is remarkable for its side effects, including liver damage. The pharmaceutical company based in Switzerland Helsinn is responsible for the original production of nimesulide in 1976, although the patent protection has been completed since. Today, nimesulide is undergoing more than 50 brands around the world, including Lomotil, Renov, something, Lamisil, Nimesil, Nimulide and Sulide. It works by deactivating cox-2, enzyme accused of the way of inflammation and pain. Therefore, the drug is also known as selective inhibitor COX-2.

Recommended, especially for people of 14 years and older, is a 100 -millionth tablet twice a day through oral administration. Patients can expect positive results between three and 14 days. Nimesulide is mainly used for specific pain sources, includingosteoarthrosis, which is a degenerative joint disease; and dysmenorea, a health condition characterized by the pain that women tolerate during the menstrual periods.

However, it should be noted that nimesulide treats only the symptoms of the above alimony, but not the disease itself. Nimesulide is also associated with side effects such as abdominal convulsions, diarrhea, heartburn, discomfort and vomiting. More serious side effects include swelling that includes swelling due to the accumulation of fluids in certain parts of the body.

However, hepatotoxicity or liver damage has brought about toxicity. The chemicals that cause this condition are referred to as hepatotoxins. In the 2003 book entitled Contemporary Diagnostics and Treatment in Gastroenterology The authors identified more than 900 drugs that could increase the risk of hepatotoxicity, including nimesulide. InterrogationIt was that its use and production of drugs was banned or suspended in several countries, including India, Singapore, the United Kingdom, Denmark and Finland. It is sold in the United States where The Food and Drug Administration (FDA) did not evaluate the medicine.

Nimesulide still remains popular in some countries, and there are societies that still produce and sell the drug, sometimes illegally depending on the jurisdiction that are below. In addition, the European Agency for Medicines (EMA) argues at least controlled use and distribution of drugs.