What Is Disulfiram?

Disulfiram-like reaction, also known as disulfiram-like reaction or drunk appearance reaction, refers to the inhibition of acetaldehyde dehydrogenase by disulfiram-like reaction, hindering the normal metabolism of ethanol, so that drinking a small amount of ethanol can also cause disulfiram-like reaction. Reaction of aldehyde poisoning. Disulfiram, also known as quitting sulfur, will cause weakness, dizziness, drowsiness, hallucinations, flushing, headache, nausea, vomiting, decreased blood pressure, and even shock after drinking alcohol. To achieve the purpose of quitting drinking. For generally mild reactions, they can recover without treatment. If severe reactions occur, such as respiratory depression, collapse, convulsions, and cardiac dysfunction, appropriate measures should be taken to treat them.

These two medicines cannot be taken together

Huoxiangzhengqi water generally contains 40% to 50% alcohol. Taking it with cephalosporins may cause disulfiram-like reactions. May induce chest pain, myocardial infarction, acute heart failure, dyspnea, acute liver injury, convulsions and even death.

What is disulfiram-like reaction more

Disulfiram is often used as an alcohol sensitizer, in order to train drinkers to react to alcohol's aversion to alcohol during drinking to achieve the purpose of abstaining from alcohol. This feeling of aversion is disulfiram-like reaction.

Not all cephalosporins are more dangerous

Cephalosporins contain many types. Not all cephalosporins combined with alcohol produce disulfiram-like reactions. Only cephalosporins containing thiomethyltetrazole groups have disulfiram-like reactions. In addition to Huoxiangzhengqi water, you should avoid the beginning spores when taking ten drops of water and bone water.

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Basic Information

Chinese name

Disulfiram-like reaction

Foreign name

disulfiram-like reaction

Alias

Quitting sulfur-like reaction

Application

Quit drinking

Response characteristics

Acetaldehyde accumulation in the body

Appear

1948

Causes of disulfiram-like reactions

In addition to disulfiram, metronidazole, furazolidone, tolbutamide, chlorpromazide, and some cephalosporins (such as cefmetazole, cefmendol, cefoperazone, and cephem Methoxime, cefotiam, oxycefax, etc.) can cause this reaction. Patients should be warned against alcohol and alcohol-containing medications.

Clinical manifestations of disulfiram-like reactions

Drinking alcohol (or exposure to alcohol) during the medication, manifested as chest tightness, shortness of breath, edema of the throat, lip cyanosis, dyspnea, increased heart rate, decreased blood pressure, limb weakness, facial flushing, sweating, insomnia, headache, nausea, vomiting, dazzling, Drowsiness, hallucinations, nausea, and even anaphylactic shock, blood pressure dropped to 60-70 / 30-40mmHg, accompanied by loss of consciousness. Easily misdiagnosed as acute coronary syndrome, heart failure, etc. In addition, the severity of the disulfiram-like reaction was directly proportional to the dose of the applied drug and the amount of alcohol consumed. Liquor drinking was more reactive than drinking beer and alcoholic beverages. Drinking alcohol during the medication period was more severe than drinking alcohol.

Disulfiram-like reaction therapy

1. The patient rests in bed, and the shocked person adopts a "V" position.

2. Keep the airway unobstructed, give oxygen inhalation 4 6L / min, and improve tissue hypoxia.

3. Establish a venous channel, and give dexamethasone 5-10mg to a glucose solution by intravenous drip or intravenous injection, rehydration and diuresis, and give vasoactive drugs according to the condition.

4. Treat symptomatically. For nausea and vomiting, 10 mg intramuscular injection of metoclopramide can be given; for drowsiness and unconsciousness, naloxone can be given anti-treatment.

5. Prepare emergency equipment and medicines, such as defibrillator, sputum suction device, tracheotomy bag and venipuncture bag, respiratory stimulant, diuretic, etc.

6. Observe the patient's consciousness, temperature, pulse, respiration, heart rate, heart rate, blood pressure, urine volume and other clinical changes, and make a record of the dynamic state of the nursing.

Precautions for disulfiram-like reactions

1. After drinking alcohol, avoid using drugs that can cause disulfiram-like reactions until the alcohol is eliminated from the body.

2. When using drugs that can cause disulfiram-like reactions, alcoholic beverages and foods containing alcohol should be banned during the medication and as long as possible (up to one week) after discontinuation.