What is the connection between methotrexate and hair loss?
Methhotrexate is a strong drug used to treat various health conditions such as autoimmune diseases and cancer. It can also have very serious side effects, including the weakness of the immune system and alopecia or hair loss. The Link Between Methotrexate and Hair Loss, As Well Potentially Causing Other Side Effects, Has To With the Way The Drug Works in the body.
cells manufacture folic acid using Essential to Cell Life and Reproduction, Including Deoxyribonucleic Acid (DNA), Ribonucleic Acid (RNA), and Proteins. This medicine prevents the proper operation of dihydropholate reductase, thus preparing cells on a compound that is necessary for them to flourish. Because only cells that are about to divide are produced more DNA, this treatment focuses mainly on cells quickly with it. This is because of this connection with rapidly dividing cells, that methotrexate and hair loss combine.
The bone marrow cells and cells that produce cells involved in autoimmune diseases are divided relatively quickly. For this reason, methotrexate against these conditions is extremely effective. Hair follicle cells do not divide as quickly as cancer or bone marrow cells, but are still dividing quite quickly, up to once a day and a half. Therefore, this medicine can easily affect follicle cells, prevent their DNA production so that they cannot split and prevent them from surviving the proteins they need to survive.
When hair follicles cells die out, they can no longer hold the hair in place and the hair begins to weaken and fall out. The connection between methotrexate and hair loss is one of the more significant side effects. Other side effects such as nausea and vomiting are caused by the same effect of methotrexate because they affect the cells in the stomach and intestines rapidly.
Unlike some JInch of powerful chemotherapeutic drugs that focus on specific places, injections and oral forms of this drug are used to distribute methotrexate throughout the body. It was first developed to fight the immune system cancer, such as leukemia, based on this ownership. The ability of this drug to move quickly through blood circulation and access to many parts of the body quickly means that its side effects tend to be of global nature, even at smaller doses. Regardless of the dosage and size schedule, there are problems with methotrexate and hair loss generally inseparable events. However, the connection between methotrexate and hair loss is not permanent; After treatment, hair often grows, albeit thinner than before.