What is naloxone hydrochloride?
Naloxone hydrochloride is a drug that is often used to treat symptoms of emergency overdose or withdraw opioid drugs. It is usually administered intravenously to act against overdose, such as heroin or morphine, and may reduce the symptoms of the withdrawal when the patient is dependent on these medicines. In some cases, doctors use naloxone HCl to treat septic shock cases in which the patient is at risk of death by overdose. It is considered a pure opioid antagonist, which means that it acts or reverses the effects of opioid drugs in the patient's system.
When the patient is admitted to the hospital after an overdose of opioid and suffers from toxicity, naloxone hydrochloride is often given to reverse the effects. OPTAVE overdose signs may include coma, convulsions and extreme sedation. When the patient suffers from respiratory depression, HC1 dosage -dosage often reverse effects and restore normal breathing. If doctors nEjsou sure whether the handover of the emergency patient passes, a small amount of drug is often administered; A good reaction to Naloxon HCI confirms the diagnosis of opiate toxicity. In the case of septic shock caused by opioid, doctors used the drug to increase the patient's blood pressure, although it has not been shown to reduce the rate of death in these patients. Finally, Naloxon HCL can be used in cases where there is a suspected drug use; If a small dose is given to the patient's system, it can immediately cause symptoms of similar withdrawal.
naloxone hydrochloride is often administered by intravenous injection and takes effect in one to two minutes. It can also be administered by intramuscular injection, in which case it will occur in two to five minutes. NALOXON HCL interacts with receptors in the central nervous system to act against the effects, but the exact mechanism that happens is unknown. The drug is metabolized by the liver and is excreted from the body of the urine. Up to 70 percent of the drug leaves the body after the first 72 hours. It is known that drugs exceed the placental wall, but are considered safe for use in pregnant women suffering from opiate overdose. American food and drug administration mentioned it as a medicine pregnancy category B.
naloxone hydrochloride is contraindicated in patients with a history of allergic reactions to the drug and also in patients with lung disease or cardiovascular disease. It is also not recommended in patients known to be dependent on opiates, as it can often cause immediate withdrawal symptoms. The use of naloxone HCI can cause extreme side effects including convulsion, increased or reduced blood pressure, pulmonary edema and violent behavior. Less serious effects include abundant sweating, nausea, vomiting and trembling.