What Is Phenylpropanolamine?

Phenylpropanolamine is a chemical substance with the chemical formula C 9 H 13 NO and is a phenethylamine drug. It is an airway dilator.

Phenylpropanolamine is a chemical substance with the chemical formula C 9 H 13 NO and is a phenethylamine drug. It is an airway dilator.
Chinese name
Phenylpropanolamine
Foreign name
Phenylpropanolamine, PPA
Also known as
Norephedrine or norephedrine
Molecular formula
C9H13NO
CAS number
14838-15-4
Classification
Airway dilator

Introduction to Phenylpropanolamine

Currently in the United States, young women must have a prescription to purchase the drug, and there are no restrictions in other regions. A drug that is commonly used to collect nasal fluid can make the blocked upper airways and trachea open. In Hong Kong, the most common package is a round medicine cake with white and green underneath. The most common drug on the market that contains PPA is Neozap.

Phenylpropanolamine Basic Information

Chinese name: phenylpropanolamine
Chinese alias: desmethylephedrine; racemic norephedrine;
English name: Bencenemethanol, Phenylpropanolamine
English alias: PHENYLPROPANOLAMINE; Norpseudoephedrine; (1S, 2R) -2-amino-1-phenyl-propan-1-ol; (1S, 2R) -2-amino-1-phenylpropan-1-ol; (1S, 2R) 2-azanyl-1-phenyl-propan-1-ol; BenzeneMethanol, a-[(1R) -1-aMinoethyl]-, (aS) -rel-; Norefedrine
CAS number: 14838-15-4
Molecular formula: C 9 H 13 NO
Molecular weight: 151.20600
Exact mass: 151.10000
PSA: 46.25000
LogP: 1.76750

Phenylpropanolamine Properties

Density: 1.072 g / cm 3
Boiling point: 288.143ºC at 760 mmHg
Flash point: 128.065ºC [1]

Calculated Chemical Data for Phenylpropanolamine

1. Hydrophobic parameter calculation reference value (XlogP): None
2.Number of hydrogen-bonded donors: 2
3.Number of hydrogen bond acceptors: 2
4.Number of rotatable chemical bonds: 2
5.Number of tautomers: none
6.Topological molecular polar surface area: 46.2
7.Number of heavy atoms: 11
8.Surface charge: 0
9.Complexity: 110
10.Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 2
12. Uncertain number of atomic stereocenters: 0
13. Determine the number of chemical bond stereocenters: 0
14. Uncertain number of chemical bond stereocenters: 0
15. Number of covalent bond units: 1 [2]

Phenylpropanolamine Related Drug Information

1 Phenylpropanolamine 1 dosage form

25mg;
Nasal drops: 1% to 3%.

2 Pharmacological effects of phenylpropanolamine 2 norephedrine

The pharmacological effect is similar to that of ephedrine, which can directly stimulate the adrenaline receptors or indirectly by releasing norepinephrine. It differs from ephedrine in that it has a slightly stronger vasoconstrictive effect, while its central excitatory effect and bronchodilator effect are weaker.

3 Pharmacokinetics of Phenylpropanolamine 3 Norephedrine

Oral absorption is easy and complete, and the highest concentration can be reached in plasma within about 1 to 2 hours. Most are excreted in the original form through the urine.

4 Indications for phenylpropanolamine 4 norephedrine

Norphedrine is clinically applied to nasal mucosal congestion; urinary incontinence; and loss of appetite. Can also be used for coma.

5 Contraindications of phenylpropanolamine 5 norephedrine

Hypertension, overweight and elderly people are prohibited or used with caution.

6 Phenylpropanolamine 6 precautions

Systemic application has a narrow safety range, and severe hypertensive reactions can occur when doses exceed 100 mg. Cerebral hemorrhage, ventricular arrhythmia, and myocardial damage can still occur. Symptoms of central excitement include anxiety, insomnia, hallucinations, and dizziness.

7 Adverse reactions of phenylpropanolamine 7 norephedrine

A severe hypertensive response can occur when the dose exceeds 100 mg. Cerebral hemorrhage, ventricular arrhythmia, and myocardial damage can still occur.

8 Dosage of phenylpropanolamine 8 norephedrine

1% to 3%; oral: 25mg, 3 times / d.

9 Interaction of phenylpropanolamine 9 norephedrine with other drugs

Combination with indomethacin can cause severe hypertension, and inhibition of prostaglandin synthesis leads to an increase in the sympathomimetic effect of norephedrine.

10 Phenylpropanolamine 10 Drug Evaluation

There are many aliases for coffee norephedrine. The pharmacological effect is similar to that of ephedrine. The central excitatory effect and bronchodilator effect are weak. The safety scope of systemic application is narrow, high blood pressure, overweight, and disabled or used with caution in the elderly.

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