What Is Phenylpropanolamine?
Phenylpropanolamine is a chemical substance with the chemical formula C 9 H 13 NO and is a phenethylamine drug. It is an airway dilator.
- Chinese name
- Phenylpropanolamine
- Foreign name
- Phenylpropanolamine, PPA
- Also known as
- Norephedrine or norephedrine
- Molecular formula
- C9H13NO
- CAS number
- 14838-15-4
- Classification
- Airway dilator
- Phenylpropanolamine is a chemical substance with the chemical formula C 9 H 13 NO and is a phenethylamine drug. It is an airway dilator.
Introduction to Phenylpropanolamine
- Currently in the United States, young women must have a prescription to purchase the drug, and there are no restrictions in other regions. A drug that is commonly used to collect nasal fluid can make the blocked upper airways and trachea open. In Hong Kong, the most common package is a round medicine cake with white and green underneath. The most common drug on the market that contains PPA is Neozap.
Phenylpropanolamine Basic Information
- Chinese name: phenylpropanolamine
- Chinese alias: desmethylephedrine; racemic norephedrine;
- English name: Bencenemethanol, Phenylpropanolamine
- English alias: PHENYLPROPANOLAMINE; Norpseudoephedrine; (1S, 2R) -2-amino-1-phenyl-propan-1-ol; (1S, 2R) -2-amino-1-phenylpropan-1-ol; (1S, 2R) 2-azanyl-1-phenyl-propan-1-ol; BenzeneMethanol, a-[(1R) -1-aMinoethyl]-, (aS) -rel-; Norefedrine
- CAS number: 14838-15-4
- Molecular formula: C 9 H 13 NO
- Molecular weight: 151.20600
- Exact mass: 151.10000
- PSA: 46.25000
- LogP: 1.76750
Phenylpropanolamine Properties
- Density: 1.072 g / cm 3
- Boiling point: 288.143ºC at 760 mmHg
- Flash point: 128.065ºC [1]
Calculated Chemical Data for Phenylpropanolamine
- 1. Hydrophobic parameter calculation reference value (XlogP): None
- 2.Number of hydrogen-bonded donors: 2
- 3.Number of hydrogen bond acceptors: 2
- 4.Number of rotatable chemical bonds: 2
- 5.Number of tautomers: none
- 6.Topological molecular polar surface area: 46.2
- 7.Number of heavy atoms: 11
- 8.Surface charge: 0
- 9.Complexity: 110
- 10.Number of isotope atoms: 0
- 11. Determine the number of atomic stereocenters: 2
- 12. Uncertain number of atomic stereocenters: 0
- 13. Determine the number of chemical bond stereocenters: 0
- 14. Uncertain number of chemical bond stereocenters: 0
- 15. Number of covalent bond units: 1 [2]
Phenylpropanolamine Related Drug Information
1 Phenylpropanolamine 1 dosage form
- 25mg;
- Nasal drops: 1% to 3%.
2 Pharmacological effects of phenylpropanolamine 2 norephedrine
- The pharmacological effect is similar to that of ephedrine, which can directly stimulate the adrenaline receptors or indirectly by releasing norepinephrine. It differs from ephedrine in that it has a slightly stronger vasoconstrictive effect, while its central excitatory effect and bronchodilator effect are weaker.
3 Pharmacokinetics of Phenylpropanolamine 3 Norephedrine
- Oral absorption is easy and complete, and the highest concentration can be reached in plasma within about 1 to 2 hours. Most are excreted in the original form through the urine.
4 Indications for phenylpropanolamine 4 norephedrine
- Norphedrine is clinically applied to nasal mucosal congestion; urinary incontinence; and loss of appetite. Can also be used for coma.
5 Contraindications of phenylpropanolamine 5 norephedrine
- Hypertension, overweight and elderly people are prohibited or used with caution.
6 Phenylpropanolamine 6 precautions
- Systemic application has a narrow safety range, and severe hypertensive reactions can occur when doses exceed 100 mg. Cerebral hemorrhage, ventricular arrhythmia, and myocardial damage can still occur. Symptoms of central excitement include anxiety, insomnia, hallucinations, and dizziness.
7 Adverse reactions of phenylpropanolamine 7 norephedrine
- A severe hypertensive response can occur when the dose exceeds 100 mg. Cerebral hemorrhage, ventricular arrhythmia, and myocardial damage can still occur.
8 Dosage of phenylpropanolamine 8 norephedrine
- 1% to 3%; oral: 25mg, 3 times / d.
9 Interaction of phenylpropanolamine 9 norephedrine with other drugs
- Combination with indomethacin can cause severe hypertension, and inhibition of prostaglandin synthesis leads to an increase in the sympathomimetic effect of norephedrine.
10 Phenylpropanolamine 10 Drug Evaluation
- There are many aliases for coffee norephedrine. The pharmacological effect is similar to that of ephedrine. The central excitatory effect and bronchodilator effect are weak. The safety scope of systemic application is narrow, high blood pressure, overweight, and disabled or used with caution in the elderly.