What Is the Connection Between Aspirin and Platelets?

Aspirin can reduce myocardial infarction, sudden cardiac death, and stroke in high-risk patients. However, in the case of regular taking aspirin, cardiovascular and cerebrovascular events still occur, which is called aspirin resistance (AR). Aspirin resistance may appear as soon as you start taking aspirin, or it may appear after taking a period of time (effective). Tests have shown that aspirin resistance can develop in some individuals over time with fixed doses of aspirin. Although the dosage of aspirin required to inhibit platelets varies from individual to individual, aspirin resistance exists even at 1300 mg / ml.

Aspirin resistance

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Early research estimates that the incidence of aspirin resistance in the population is 8% to 45%. Clinical observations

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At present, the treatment of AR is still being explored. The main solutions are:

Choose the right dose. Some scholars have suggested that some patients are dose-dependent on aspirin, and AR can be treated by increasing the aspirin dose. However, there is also a contrary view that increasing aspirin dose does not reduce the risk of cardiovascular events, but increases adverse reactions.

Avoid drug interactions. FitzGerald pointed out that the combination of certain drugs may affect the efficacy of aspirin. For example, non-steroidal anti-inflammatory drugs may prevent aspirin from acting on serine sites by competitively blocking the active site of COX. Patients with aspirin should avoid concurrent use of these drugs.

clopidogrel. Platelet ADP receptor antagonist clopidogrel is one of the options, but there have been reports of clopidogrel resistance in recent years.

platelet glycoprotein b / a receptor antagonist. Its antiplatelet effect is positive, but the risk of bleeding is higher, the price is more expensive, and there is currently no oral dosage form, mainly for short-term use in hospitalized patients, there is no evidence for long-term use.

It is reported that Fufang Danshen Diwan combined with aspirin is a useful supplement to AR therapy, and the liver and kidney function of the subjects monitored before and after the test did not change. ^[1]

In addition, aspirin combined with Fufang Danshen Diwan can reduce the platelet aggregation rate; Fufang Danshen Diwan can be used as a supplementary treatment for patients with aspirin resistance. ^[2]