What is the connection between aspirin and blood plates?
Aspirin is an oral medicine that has anti-inflammatory and blood-thinning properties. It inhibits the formation of blood clots by preventing plates in the production of a chemical called the Thidoxane A-2, which usually induces clustering of plates. When aspirin and plates interact, the drug blocks the effect of the cyclooxygenase-1 (COX-1) enzyme, which forms thromboxane A-2. Without thromboxan A-2, the plates cannot stick together and connect with fibrin to form a blood clot. While other reagents also block the COX-1 enzyme, the antiasslothelet effect of aspirin takes several days compared to several hours for other agents, making it a preferred choice according to many doctors for long-term prevention of heart attacks and secondary strokes to blood clots.
The connection between aspirin and plates was well studied in clinical trials. At doses of 325 milligrams a day, the greatest anti -aggregation effect occurs within 30 minutes after ingestion. Low -dose aspirin, However, may take up to several days to reachyour strongest effect. For this reason, doctors recommend a regular dose of aspirin when patients experience the symptoms and symptoms of chest, heart attack and stroke. Unlike other anti-aggregation drugs, aspirin only blocks the path of cox-1 Tromboxan formation A-2, allowing some normal platelet activity.
further demonstrating the relationship between aspirin and blood plates, one large multicentric study of patients with acute infarction revealed a 23 % reduction in mortality when aspirin was administered with 24 hours of symptoms. Contemporary recommendations for patients suffering from severe chest pain, shortness of breath, prying, nausea and pain radiating into the jaw or arm is to take regular aspirin as soon as the symptoms develop and continue to aspirin for one month. Although aspirin does not open a blocked vessel existing blood clot, it prevents the growth of this clot andprevents more clots from forming. In this way, Aspirin limits the extent in which the heart tissue becomes starving for oxygen, thereby limiting damage.
Cerebrovascular accident (CVA) or stroke is damage that occurs in the brain or body due to reduced blood flow. Common contributors to stroke include narrowing blood vessels due to cholesterol and damage to high blood pressure, as well as blood clots or cholesterol plaques that move in the bloodstream and are stored in a small blood vessel. The connection between aspirin treatment and blood plates in patients with stroke is revealed in several studies that show that mild aspirin administration during the first 48 hours of symptoms dramatically increases survival, reduces the severity of neurological deficits and prevents other strokes. Doctors recommend doses160 to 350 milligrams to be given as soon as patients notice classic symptoms of stroke, including weakness, insensitivity, changes inIze, problems with difficulty and balancing problems.
Although research continues in connection between aspirin and blood plates, aspirin is not always the best solution to blood clot problems. Significant side effects of aspirin include allergic reactions, asthma, bleeding ulcers and bleeding in the brain. Poor candidates for aspirin therapy include pregnant women or breastfeeding mothers, children and kidney patients or gastrointestinal diseases. On the other hand, most doctors prescribe low doses of aspirin for patients with severe atherosclerosis and history of previous heart attacks, previous strokes or mini-tits, chest pain with exercise and reduced blood flow at the ends.