What is a complicated human insulin?
Rekombinant human insulin is a commercial hormone used to treat patients suffering from diabetes. Insulin, which is usually produced in the pancreatic, is used to control blood sugar levels. It works by allowing blood sugar to pass into the body cells so that the cells can use it for energy. If the patient is a diabetic and cannot produce insulin, blood sugar levels will increase, which could cause serious health problems. Insulin must then be injected daily to maintain a constant level of levels of blood sugar levels. Beef insulin from cows differs from human insulin by three amino acids, while pig insulin from pigs differs from human insulin with one amino acid. Some diabetic patients may develop an allergic response to insulin from animals if the body recognizes it as foreign. The recombinant human insulin produced in the laboratory is identical to the hormone produced naturally and does not cause an allergic reaction. Insulin consists of two stringsThe amino acids that are connected together to form a small protein molecule. The recombinant human insulin is synthesized by the insertion of DNA from each insulin chain separately into the DNA of the weakened non-infectious tribes of Escherichia coli-mostly known as E. coli.
bacteria will then submit many cell division cycles and can produce many copies of each of the insulin chains. Individual chains of insulin molecules are extracted from bacteria and cleaned. Two chains that form a complete insulin molecule are then mixed and left to bind each other.
Supportant human insulin can be sophisticated in yeast cells. Yeast cells may secrete the complete insulin molecule containing both chains already connected together. This is an improvement compared to E.Coli production, because it eliminates the next step of mixing two chains together.
Once the full r is purifiedEcombinant Molecule of human insulin, further structural changes can be made to increase the function of the molecule. Replacing one amino acid in a certain position in the molecule can lead to insulin preparation, which is either fast -acting or long -acting. These are referred to as insulin analogs and can remain active after different lengths of time in the body. This gives the physician and flexibility of the patient in designing a protocol on the treatment of insulin -based insulin.