What Are the Side Effects of Folic Acid?

Silian Folic Acid Tablet is a kind of medicine, its main role is to prevent fetal neural tube defects (no brain deformity, spina bifida); prevent fetal cleft lip and palate; prevent fetal congenital heart disease, other body deformities and other birth defects; prevent pregnant women, nursing mothers and fetuses anemia.

Slyan folic acid tablets

Drug Name: Folic acid tablets
Alias: Slian
Foreign name: Folic Acid Tablets

Adverse reactions: Fewer adverse reactions and rare allergic reactions.
Approval Number: National Medicine Standard H10970079
Drug type: Domestic medicine

1, can prevent chronic cardiovascular disease such as coronary heart disease.

2, can prevent dementia and other cancers, reduce the incidence.

3. Reduce and prevent the incidence of breast and cervical cancer in women.

4. Prevention and treatment of megaloblastic anemia caused by drugs.

5.Promote the fetal nervous system

Generally from 3 months before pregnancy to 3 months after pregnancy, folic acid should be supplemented according to the recommended amount. However, iron supplementation must be based on the physical fitness of the pregnant woman and must not be performed blindly. Iron intake is not good. If you take too much iron for a long time, you can cause various diseases, even iron poisoning.

You can go to the hospital to check the most common blood routine to see if it is iron deficiency anemia. Generally speaking, if you have a rich diet, you can eat a certain amount of red meat every day (the recommended amount is 100 ~ 200 grams), such as beef, mutton, and pork, which can basically meet the needs.

In the second to third trimester of pregnancy, the nutritional needs of pregnant women are gradually increasing. Some vitamins and minerals may need to be added, which can be supplemented according to the doctor's advice.

In short, there are two principles for nutritional supplements: first, don't use nutritional supplements that can be supplemented from ordinary food; second, pay attention to the dosage, too much, and lack and excess may also have side effects on the human body.

common name

Folic acid tablets

Product name

Slian

Approval Number

National Medicine Standard H10970079

English name

Folic Acid Tablets

[Chinese Pinyin]

Yesuan Pian

[Character]

This product is yellow or orange yellow tablets

[ Category ]

Domestic Western Medicine> Blood System Drugs> Anti Anemia Drugs> Folic Acid Tablets

Pharmacology and Toxicology of Silian Folic Acid Tablets

Folic acid is a water-soluble B vitamin consisting of pteridine, p-aminobenzoic acid, and glutamic acid residues. It is an essential substance for the growth and reproduction of body cells. Exist in liver, kidney, yeast and green leafy vegetables such as beans, spinach, tomato, carrot, etc., and can now be synthesized artificially. Folic acid forms tetrahydrofolate (THFA) through the action of dihydrofolate reductase and vitamin B12, which combines with a variety of one-carbon units (including CH3, CH2, CHO, etc.) to form tetrahydrofolate coenzymes, delivering one-carbon units It is involved in many important reactions in the body and the synthesis of nucleic acids and amino acids. THFA forms N5,10 methylenyltetrahydrofolate under the action of serine transhydroxylase, which can promote uracil nucleotides (dUMP) to form thymine nucleotides (dTMP), which can be involved in cell DNA synthesis. Promote cell division and maturation. During DNA synthesis, deoxyuridine is converted to deoxythymidylate, during which the required methyl group is provided by methylenetetrahydrofolate. In the absence of folic acid, DNA synthesis is slowed, but RNA synthesis is not affected. As a result, blood cells in the bone marrow have larger volumes and the nucleus develops more naive blood cells, especially red blood cells. Timely supplementation may have a therapeutic effect.

Pharmacokinetics of Silian Folic Acid Tablets

After oral administration, it is mainly absorbed in the proximal part of the jejunum in a reduced form, appears in the blood within 5-20 minutes, and reaches a peak one hour later, and its t1 / 2 is about 0.7 hours. Anemia patients absorb faster than normal people. Folic acid enters the liver from the portal vein and is stored in the liver in the form of N5-methyltetrahydrofolate and distributed to other tissues and organs. The amount of folic acid stored in the liver is about 1/3 to 1/2 of the total body. About 90% of the therapeutic amount of folic acid is excreted from the urine, and 20% to 30% appear in the urine 2 hours after the high-dose injection.

Sirian folic acid tablets indications

Folic acid deficiency caused by various causes and megaloblastic anemia caused by folic acid deficiency;

Prophylactic administration for pregnant and lactating women;

Folic acid deficiency caused by chronic hemolytic anemia;

Sirian folic acid tablets dosage

Oral: Adults, 5-10mg once a day, 15-30mg a day, until the blood picture returns to normal;

Children, 5 mg once a day, 3 times a day (or 5 to 15 mg a day, 3 times a day);

Prevention: 0.4mg once, once a day.

Adverse effects of slian folic acid tablets

Fewer adverse reactions and rare allergic reactions. Long-term medication can cause gastrointestinal symptoms such as anorexia, nausea, and bloating. When taking folic acid in large amounts, it can make urine yellow.

Contraindications to Sirian Folic Acid Tablets

Megaloblastic anemia caused by vitamin B12 deficiency cannot be treated with folic acid alone

Precautions for Slyan folic acid tablets

(1) Intravenous injection is more likely to cause adverse reactions, so it should not be used; When intramuscular injection, it should not be injected with vitamin B1, vitamin B2, and vitamin C in the same tube;

(2) Oral high-dose folic acid can affect the absorption of trace element zinc;

(3) Do not take medicine until the diagnosis is clear. For experimental treatment, use a physiological amount (0.5mg a day) orally;

(4) Nutritional megaloblastic anemia is often associated with iron deficiency, and iron should be added at the same time, as well as protein and other B vitamins;

(5) Patients with pernicious anemia and suspected vitamin B12 deficiency should not use folic acid alone, because this will increase the burden of vitamin B12 and neurological symptoms.

(6) Maintenance treatment is generally not required, except for patients with malabsorption;

[Medication for pregnant and lactating women]

Applicable to this product

Sirian Folic Acid Drug Interactions

Large doses of folic acid can antagonize the antiepileptic effects of phenobarbital, phenytoin, and primidone, which can significantly reduce the threshold of seizures and increase the number of seizures in sensitive patients;

Oral high-dose folic acid can affect the absorption of trace element zinc.

Sirian Folic Acid Tablets Overdose

Because high-dose folic acid can antagonize the antiepileptic effect of phenobarbital, phenytoin, and polimetone, it can significantly reduce the threshold of seizures and increase the number of seizures in sensitive patients. Therefore, the dose of folic acid used in these patients should not exceed 1 mg, and it is advisable to not exceed 400 g to avoid affecting the condition;

Storage

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