What is Triclosan?

Triclosan, scientific name "dichlorophenoxychlorophenol", chemical formula is C ₁₂ H ₇ Cl ₃ O ₂ , also known as "triclosan", "triclosan", etc., triclosan is normally white or off-white crystal Powdery powder with slight phenol odor. Insoluble in water, easily soluble in lye and organic solvents. Triclosan is a broad-spectrum antibacterial agent and is widely used in daily chemicals such as soap and toothpaste. It is also detected in human breast milk or urine. As for the statement that triclosan is carcinogenic in toothpaste, relevant experts stated on November 29, 2011 that there is no scientific research to prove that triclosan in toothpaste can cause cancer, but recent research results have shown that triclosan can cause cancer. Mouse liver cancer and liver fibrosis need to pay close attention to its toxic and side effects on the human body! ^[1]

Triclosan

Triclosan, scientific name "dichlorophenoxychlorophenol", chemical formula is C ₁₂ H ₇ Cl ₃ O ₂ , also known as "triclosan", "triclosan", etc., triclosan is normally white or off-white crystal Powdery powder with slight phenol odor. Insoluble in water, easily soluble in lye and

Triclosan is widely used in high-efficiency medicinal soaps / hygienic soaps, sanitary lotions, body odor / foot aerosols, hand sanitizers, wound disinfection sprays, medical device disinfectants, sanitary facial cleansers / creams, air fresheners, and refrigerator deodorants It is also used in the finishing of sanitary fabrics and the preservation and treatment of plastics. Higher purity triclosan is also widely used in the treatment of toothpaste and mouthwash, such as dentitis, periodontitis, and oral ulcers. The recommended concentration is 0.05% -0.3%.

[Storage]: Sealed, dry and dark place, storage temperature does not exceed 40

In the United States, triclosan is mainly made up of

Mild teratogenicity

An experiment by Physician Bide of the Virginia Tech University in the United States showed that products containing triclosan react with tap water containing chlorine to form a substance called "growth", which is chloroform. And chloroform has been used as an anesthetic. Animal experiments have found that this substance can cause damage to the heart and liver, and is mildly teratogenic. It can induce liver cancer in mice, but there is no research data on carcinogenesis in humans.

Impairs muscle function

According to researchers at the University of California, Davis and the University of Colorado, as a class of antibacterial agents widely used in hand sanitizers and other personal care products, triclosan can prevent muscle contraction at the cellular level and reduce fish swimming speed Decreased muscle strength in mice.

The team also found that triclosan impairs the contractile function of the heart and skeletal muscle of living animals. Heart function decreased by 25% in anesthetized mice within 20 minutes of exposure to the substance

The application of experimental results from animal models to humans is a large span and requires more in-depth research. But because the effect in animal models is so significant under different experimental conditions, it can effectively prove that triclosan can affect the health of animals and humans under the current exposure levels. ^[3]

Toxicity data from literature and journals

Numbering	Toxicity type	testing method	Test object	Dosage used	Toxic effect
1	Acute toxicity	oral	Rat	3700 mg / kg	Detailed effects are not reported other than lethal dose
2	Acute toxicity	Intraperitoneal injection	Rat	89 mg / kg	Detailed effects are not reported other than lethal dose
3	Acute toxicity	Subcutaneous injection	Rat	3900 mg / kg	Detailed effects are not reported other than lethal dose
4	Acute toxicity	Intravenous injection	Rat	29 mg / kg	Detailed effects are not reported other than lethal dose
5	Acute toxicity	oral	Mouse	4530 mg / kg	Detailed effects are not reported other than lethal dose
6	Acute toxicity	Intraperitoneal injection	Mouse	84 mg / kg	Detailed effects are not reported other than lethal dose
7	Acute toxicity	Subcutaneous injection	Mouse	3800 mg / kg	Detailed effects are not reported other than lethal dose
8	Acute toxicity	Skin surface	rabbit	9300 mg / kg	Detailed effects are not reported other than lethal dose
9	Ocular toxicity	Skin surface	Humanity	750 ug / 3D (intermittent)	Lighter
10	Ocular toxicity	Skin surface	rabbit	10%	Lighter
11	Mutation toxicity		Bacillus subtilis	5 mg / disc
12	Reproductive toxicity	oral	Rat	4400 mg / kg, 7-17 days after conception	1. Reproductive toxicity-embryo or fetal death

References for substance toxicity: ^{[5] [5-7] [5] [8-9]}