Why shouldn't I combine simvastatin and grapefruit?

Simvastatin and grapefruit should not be combined because the presence of grapefruit in the person's system makes it difficult to break the active chemicals in simvastatin. This can lead to a situation where there is too much simvastatin in a person's body or where the drug remains in the body for too long. Whether these situations can lead to serious health complications. In most cases, it is safe to drink grapefruit juice or eat grapefruit in small amounts when using simvastatin.

Although the exact reasons why Simvastatin and Grapefruit should not combine, scientists have not been well known that patients who consume large amounts of fruit have difficulty breaking simvastatin. This chemical is metabolized by enzymes in the patient's body, but it is assumed that the presence of certain grapefruit molecules is assumed to prevent these enzymes from breaking up simvastatin. The drug remains in the patient's body for a longer period of time, because the metabolized by normal speed. This means that the normal dosing mode of simvastatin can lead to a situationor when there is too much simvastatin in the patient's body at once.

If the enzymes of grapefruit finally leaves the patient's system, simvastatin can be correctly divided. Unfortunately, because the drug has not been divided at the recommended time, a large amount may persist in the body. If the molecules from several doses of simvastatin are divided at once, overdose may occur even if the patient has taken medication in the right times. Unexplained pain in muscles or joints, painful urination, dizziness and loss of consciousness are possible symptoms of too much of this drug in the patient's body.

To prevent the risk of potentially serious interaction between simvastatin and grapefruit, patients taktedocage that this medicine does not eat much grapefruit during treatment. Drinking large amounts of grapefruit juice and the use of extract or grapefruit supplements can also cause interaction between simvastatin and grapefruit. In most pHowever, it is safe to drink up to a liter of grapefruit juice or eat the equivalent throughout the fruit every day when taking this medicine. However, consumption and a small amount of grapefruit can lead to a dramatic increase in the amount of simvastatin in the body of the person and should be done carefully.