What Are T Helper Cells?

CD4 expressing T cells are usually attributed to helper T cells (TH). These cells can be divided into two main parts according to their functions, their response to different cytokines, and their ability to secrete cytokines. TH cells are now thought to initiate In precursor cells capable of secreting IL-2, after initial stimulation, these cells develop into THO cells, which can secrete several cytokines, including IFN-, IL-2, IL-4, IL-5 and IL-10 .

Helper T cell

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CD4 expressing T cells are usually attributed to helper T cells (TH). These cells can be divided into two main parts according to their functions, their response to different cytokines, and their ability to secrete cytokines. TH cells are now thought to initiate In precursor cells capable of secreting IL-2, after initial stimulation, these cells develop into THO cells, which can secrete several cytokines, including IFN-, IL-2, IL-4, IL-5 and IL-10 .

Chinese name

Helper T cell

Foreign name

Helper T cell

Use

Response to different cytokines

development of

gE secretion and atopic disease

Immune.

Enhance humoral immunity.

CD4 expressing T cells are usually attributed to helper T cells (TH). These cells can be divided into two main parts according to their functions, their response to different cytokines, and their ability to secrete cytokines. TH cells are now thought to initiate In precursor cells capable of secreting IL-2, after initial stimulation, these cells develop into THO cells, which can secrete several cytokines, including IFN-, IL-2, IL-4, IL-5 and IL-10 According to the action of cytokines, THO cells can develop into TH1 or TH2 cells. IFN- and IL-12 are conducive to the development of TH1, while IL-4 and IL-10 are beneficial to the development of TH2. TH1 cells secrete IFN- TH2 secretes IL-4, however, these two subclasses equally secrete several other cytokines (such as IL-3, GM-CSF, TNF-). In general, TH1 is good for enhancing cellular immunity, and TH2 is good for Enhance humoral immunity.

The mentioned TH1 and TH2 responses have changed perceptions about the relationship between the immune system and disease. An immune response should not only be energetic, but also moderate to infection or disease. The best example is leprosy, which is now believed to cause tuberculosis Like leprosy, and TH2 response causes neoplastic leprosy. Furthermore, TH1 response can aggravate autoimmune disease, and TH2 response is conducive to IgE secretion and the development of atopic diseases.