What is matrix metalloproteinase 9?
Matrix Metalloproteinase 9 (MMP9) is an enzyme found primarily in humans, coded genes of matric metalloproteinase (MMP). Human proteins and enzymes from the decomposition of the MMP of cellular materials within normal tissue remodeling and other biological processes. MMP enzymes also contribute to the progression of certain diseases by degrading collagens, decomposing extracellular matrixs and helping metastasis. Scientists believe that MMP9 plays an integral role in metastasis of certain types of cancer and also degrading collagens in certain types of arthritis.
While matrix metalloproteinase 9 is a naturally occurring, productive enzyme necessary for tissue repair and other processes, is most often associated with cancer progression. Specifically, the MMP9 decomposes the basement membranes of the cells, giving tumors more space for growth. Cancer cells help direct MMP9 to degrade collagen IV, allowing cancer to migrate, resulting in metastases. In short, a theputor of the purpose of such enzymes becomes PROSPfor harmful cells. These categories are collagenases, gelatinases, strings and membrane types. As for matric metalloproteinase 9, this enzyme is mainly in the category of MMP gelatin. The MMP9 Gen also corresponds to certain behavioral and functional criteria of collagenases.
In scientific research, matric metalloproteinase 9 also has such names and classification as gelatinase B, 92 KDA type IV collagenase and 92 KDA gelatinase. Other names include type IV collagenase and IV-B collagenase. The Hugo (HGNC) Nomenclature Committee assigned a MMP9 symbol to replace the previous CLG4B symbol. Official symbolypos to provide consistency among scientists working in various laboratories, countries and languages.
Looking at human chromosomes and DNA, the matric metalloproteinase gene is found on Chromosome 20. As shown in HGNC, the exact location is 20Q12-Q13. Such a coordinateICE indicates the position of the gene to 20. Chromosome in the area between Q12 and Q13. As a result, scientists have found in this genetic area of amplification with regard to patients with breast and ovarian cancer. Other studies associate this genetic area with pituitary tumors, pseudo -parathyroidism and diabetes.
Structurally, MMP9 carries striking similarities to MMP2, another scientist of the MMP gene believes it helps in metastasizing cancer. In terms of homology or similarity of two structures, the amino acid sequences of MMP9 and MMP2 are such that both are commonly associated with aggressive invasive cancer. MMP9 and MMP2 enzymes degrade extracellular matric proteins with highly increased expressio of both cancer such as pancreatic, breasts and colorectal.