What Is Carbon Tetrachloride?

Carbon tetrachloride, organic compound, chemical formula CCl ₄ . It is a colorless and toxic liquid that can dissolve many substances such as fat and paint. It is a volatile liquid with a slightly sweet smell of chloroform. It has a molecular weight of 153.84, a density of 1.595g / cm ³ (20 ° C), a boiling point of 76.8 ° C, a vapor pressure of 15.26kPa (25 ° C), and a vapor density of 5.3g / L at room temperature and pressure. Carbon tetrachloride is incompatible with water and can be miscible with ethanol, ether, chloroform and petroleum ether. It is not flammable and was used as a fire extinguishing agent, but it was stopped because it can react with water above 500 degrees Celsius to produce carbon dioxide and toxic phosgene, chlorine and hydrogen chloride gas. In addition, it will accelerate the decomposition of the ozone layer. The use of carbon tetrachloride is strictly restricted by the country. It is only used for non-ozone depleting material raw materials and special applications. It is not commonly used as an extractant.

Carbon tetrachloride

CAS number: 56-23-5

MDL number: MFCD00000785

EINECS number: 203-453-4

RTECS number: 203-453-4

BRN number: 1098295

PubChem number: 24857387 ^[2]

1. Molar refractive index: 26.04

2. Molar volume (cm3 / mol): 90.6

3. Isometric Zhang Rong (90.2K): 220.7

4. Surface tension (dyne / cm): 35.2

5. Polarizability (10-24cm3): 10.32 ^[2]

1. Hydrophobic parameter calculation reference value (XlogP): 2.8

2.Number of hydrogen bond donors: 0

3.Number of hydrogen bond acceptors: 0

4.Number of rotatable chemical bonds: 0

5.Number of tautomers: none

6. Topological molecular polar surface area

7.Number of heavy atoms: 5

8.Surface charge: 0

9.Complexity: 19.1

10.Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Uncertain number of chemical bond stereocenters: 0

15. Number of covalent bond units: 1 ^[2]

Used extensively as a solvent, fire extinguishing agent, organic

Ecological toxicity

LC50: 27 ~ 125mg / L (96h) (bluegill sunfish); 20.8 ~ 41.4mg / L (96h) (blackhead fish); 45mg / L (96h) (green algae)

IC50: 600mg / L (72h) (algae)

2. Biodegradability

Aerobic biodegradation (h): 4032 ~ 8640

Anaerobic biodegradation (h): 168 ~ 672

3. Non-biodegradable

Photooxidation half-life in air (h): 1.60 × 104 ~ 1.60 × 105

First-stage hydrolysis half-life (h): 7000

4. Other harmful effects Carbon tetrachloride is a highly accumulating substance, which can accumulate in the liver of mammals and cause liver cancer in salmon. The substance's ozone depletion potential (ODP) is 1.1, which has a particularly strong destructive effect on the atmospheric ozone layer. ^[2]

There are many production methods of carbon tetrachloride, including methane thermal chlorination method, carbon disulfide chlorination method, and cogeneration

Carbon disulfide methanol methane chlorine natural gas caustic soda ethanol

Toxicity test data

Numbering	Toxicity type	testing method	Test object	Dosage used	Toxic effect
1	Acute toxicity	Inhale	Humanity	20 ppm	1. Gastrointestinal toxicity-nausea, vomiting
2	Acute toxicity	oral	Adult woman	1800 mg / kg	1. Eye Toxicity-Mydriasis 2. Behavioral Toxicity-Coma 3. Behavioral Toxicity-Suppression of Mind
3	Acute toxicity	oral	Adult male	1700 mg / kg	1. Behavioral toxicity-tremor 2. Lung, chest or respiratory toxicity-other changes 3. Gastrointestinal toxicity-other changes
4	Acute toxicity	oral	Adult male	429 mg / kg	1. Cardiotoxicity-change in heart rate 2. Lung, chest or respiratory toxicity-cyanosis 3. Kidney, ureter and bladder toxicity-interstitial nephritis
5	Acute toxicity	Inhale	Humanity	1000 ppm	Detailed effects are not reported other than lethal dose
6	Acute toxicity	Inhale	Humanity	45 ppm / 3D	1. Behavioral toxicity-lethargy 2. Behavioral toxicity-anorexia 3. Gastrointestinal toxicity-nausea and vomiting
7	Acute toxicity	Inhale	Humanity	317 ppm / 30M	1. Gastrointestinal toxicity-nausea, vomiting
8	Acute toxicity	Inhale	Humanity	5 pph / 5M	Detailed effects are not reported other than lethal dose
9	Acute toxicity	Not reported	Adult male	93 mg / kg	Detailed effects are not reported other than lethal dose
10	Acute toxicity	oral	Rat	2350 mg / kg	Detailed effects are not reported other than lethal dose
11	Acute toxicity	Inhale	Rat	8000 ppm / 4H	Detailed effects are not reported other than lethal dose
12	Acute toxicity	Skin surface	Rat	5070 mg / kg	Detailed effects are not reported other than lethal dose
13	Acute toxicity	Intraperitoneal injection	Rat	1500 uL / kg	Detailed effects are not reported other than lethal dose
14	Acute toxicity	trachea	Rat	90 mg / kg	Detailed effects are not reported other than lethal dose
15	Acute toxicity	oral	Mouse	8263 mg / kg	Detailed effects are not reported other than lethal dose
16	Acute toxicity	Inhale	Mouse	9526 ppm / 8H	Detailed effects are not reported other than lethal dose
17	Acute toxicity	Intraperitoneal injection	Mouse	572 mg / kg	Detailed effects are not reported other than lethal dose
18	Acute toxicity	Subcutaneous injection	Mouse	31 mg / kg	1. Behavioral toxicity-sleep 2. Behavioral toxicity-ataxia
19	Acute toxicity	oral	dog	1 mg / kg	Detailed effects are not reported other than lethal dose
20	Acute toxicity	Inhale	dog	14620 ppm / 8H	1. Behavioral toxicity-general anesthesia 2. Vascular toxicity-decreased blood pressure regulation 3. Nutrition and metabolic system toxicity-decreased body temperature
twenty one	Acute toxicity	Intraperitoneal injection	dog	1500 mg / kg	1. Liver toxicity-decreased liver function
twenty two	Acute toxicity	Intravenous injection	dog	125 mg / kg	Detailed effects are not reported other than lethal dose
twenty three	Acute toxicity	Inhale	Cat	38110 ppm / 2H	Detailed effects are not reported other than lethal dose
twenty four	Acute toxicity	Subcutaneous injection	Cat	300 mg / kg	1. Lung, chest or respiratory toxicity-other changes 2. Hepatotoxicity-Hepatolenticular degeneration 3. Hematological toxicity-bleeding
25	Acute toxicity	oral	rabbit	5760 mg / kg	Detailed effects are not reported other than lethal dose
26	Acute toxicity	Skin surface	rabbit	> 20 mg / kg	Detailed effects are not reported other than lethal dose
27	Acute toxicity	Intraperitoneal injection	rabbit	477 mg / kg	Detailed effects are not reported other than lethal dose
28	Acute toxicity	Subcutaneous injection	rabbit	3 mg / kg	Detailed effects are not reported other than lethal dose
29	Acute toxicity	Intravenous injection	rabbit	5840 mg / kg	1. Behavioral toxicity-excitement 2. Behavioral toxicity-coma 3. Lung, chest or respiratory toxicity-dyspnea
30	Acute toxicity	oral	Guinea Pig	5760 mg / kg	Detailed effects are not reported other than lethal dose
31	Acute toxicity	Inhale	Guinea Pig	20000 ppm / 2H	Detailed effects are not reported other than lethal dose
32	Acute toxicity	Skin surface	Guinea Pig	> 9400 uL / kg	Detailed effects are not reported other than lethal dose
33	Acute toxicity	Intraperitoneal injection	Chickens	4497 mg / kg	1. Gastrointestinal toxicity-small intestinal ulcer or bleeding 2. Gastrointestinal toxicity-other changes
34	Acute toxicity	Inhale	frog	58 gm / m3	Detailed effects are not reported other than lethal dose
35	Acute toxicity	oral	mammal	6 mg / kg	Detailed effects are not reported other than lethal dose
36	Acute toxicity	Inhale	mammal	34500 mg / m3	Detailed effects are not reported other than lethal dose
37	Chronic toxicity	oral	Rat	4800 uL / kg / 8W-I	1. Behavioral toxicity-affects food intake (animals) 2. Hepatotoxicity-hepatitis, fiber (cirrhosis, post-necrotic scar) 3. Kidney, ureter and bladder toxicity-changes in renal tubules (including acute renal failure, acute tubular necrosis)
38	Chronic toxicity	oral	Rat	1200 mg / kg / 12W-I	1. Liver toxicity-changes in liver weight 2. Biochemical toxicity-inhibit or induce mixed function oxidases (dealkylation, hydroxylation, etc.) of liver microsomes 3. Biochemical toxicity-Inhibiting transaminase activity and changing the spatial structure of transaminase
39	Chronic toxicity	oral	Rat	4197 ug / kg / 28D-I	1. Liver toxicity-other changes
40	Chronic toxicity	oral	Rat	400 mg / kg / 10D-I	1. Liver toxicity-changes in liver weight 2. Nutrition and metabolic system toxicity-weight loss or weight loss rate 3. Biochemical toxicity-inhibits transaminase activity and changes the spatial structure of transaminase
41	Chronic toxicity	Inhale	Rat	41 mg / m3 / 4H / 8D-I	1. Endocrine toxicity-hypothyroidism
42	Chronic toxicity	Inhale	Rat	61 mg / m3 / 90D-C	1. Hepatotoxicity-hepatolenticular degeneration 2. Hepatotoxicity-other changes
43	Chronic toxicity	Inhale	Rat	400 ppm / 1H / 46D-I	1. Liver toxicity-changes in liver weight
44	Chronic toxicity	Inhale	Rat	200 ppm / 7H / 27W-I	1. Hepatotoxicity-hepatitis (hepatocyte necrosis), banding 2. Hepatotoxicity-hepatolenticular degeneration 3. Chronic disease-related toxicity-death
45	Chronic toxicity	Inhale	Rat	50 ppm / 3H / 8W-I	1. Hepatotoxicity-hepatolenticular degeneration
46	Chronic toxicity	Inhale	Rat	400 ppm / 8H / 46W-I	1. Peripheral neurotoxicity-changes in nerve or nerve sheath structure 2. Chronic disease-related toxicity-death
47	Chronic toxicity	Subcutaneous injection	Rat	31200 uL / kg / 12W-I	1. Liver toxicity-hepatitis, fiber (cirrhosis, post-necrotic scar)
48	Chronic toxicity	Intraperitoneal injection	Rat	4200 uL / kg / 2W-I	1. Hepatotoxicity-other changes 2. Hematological toxicity-changes in serum composition (such as TP, bilirubin, cholesterol) 3. Biochemical toxicity-inhibit or induce phosphatase
49	Chronic toxicity	oral	Mouse	8750 mg / kg / 14D-I	1. Liver toxicity-changes in liver weight 2. Endocrine toxicity-changes in spleen weight 3. Chronic disease-related toxicity-death
50	Chronic toxicity	oral	Mouse	1080 mg / kg / 90D-I	1. Liver toxicity-changes in liver weight 2. Endocrine toxicity-changes in spleen weight 3. Biochemical toxicity-inhibition or induction of phosphatase
51	Chronic toxicity	Inhale	Mouse	20 ppm / 12W-I	1. Hepatotoxicity-hepatitis (necrosis of liver cells), spread 2. Hematological toxicity-changes in serum composition (such as TP, bilirubin, cholesterol) 3. Biochemical toxicity-inhibit or induce enzymes
52	Chronic toxicity	oral	dog	636 mg / kg / 16D-I	1. Behavioral toxicity-muscle weakness 2. Hematological toxicity-changes in coagulation factors 3. Chronic disease-related toxicity-death
53	Chronic toxicity	Inhale	dog	515 mg / m3 / 8H / 6W-I	1. Hepatotoxicity-hepatolenticular degeneration
54	Chronic toxicity	Inhale	monkey	515 mg / m3 / 8H / 6W-I	1. Lung, chest or respiratory toxicity-liver fibrosis 2. Nutrition and metabolic system toxicity-weight loss or rate of weight loss 3. Chronic disease-related toxicity-death
55	Chronic toxicity	Inhale	monkey	61 mg / m3 / 90D-C	1. Liver toxicity-other changes 2. Skin and accessory toxicity-hair changes
56	Chronic toxicity	Inhale	monkey	200 ppm / 8H / 46W-I	1. Peripheral neurotoxicity-changes in nerve or nerve sheath structure
57	Chronic toxicity	Inhale	rabbit	515 mg / m3 / 8H / 6W-I	1. Hepatotoxicity-hepatolenticular degeneration
58	Chronic toxicity	Inhale	rabbit	61 mg / m3 / 90D-C	1. Liver toxicity-other changes
59	Chronic toxicity	Inhale	rabbit	100 ppm / 7H / 30W-I	1. Nutritional and metabolic system toxicity-weight loss or weight loss rate
60	Chronic toxicity	Inhale	rabbit	100 mg / m3 / 3H / 35W-I	1. Liver toxicity-decreased liver function 2. Kidney, ureter and bladder toxicity-Changes in urine components 3. Immune system toxicity-decreased immune response
61	Chronic toxicity	Inhale	Guinea Pig	515 mg / m3 / 8H / 6W-I	1. Hepatotoxicity-Hepatolenticular degeneration 2. Nutritional and metabolic system toxicity-Weight loss or rate of weight loss 3. Chronic disease-related toxicity-Death
62	Chronic toxicity	Inhale	Guinea Pig	61 mg / m3 / 90D-C	1. Hepatotoxicity-Hepatolenticular degeneration 2. Nutritional and metabolic system toxicity-Weight loss or rate of weight loss 3. Chronic disease-related toxicity-Death
63	Chronic toxicity	Inhale	Guinea Pig	100 ppm / 7H / 33W-I	1. Liver toxicity-hepatitis (necrosis of liver cells), spread 2. Chronic disease-related toxicity-death
64	Chronic toxicity	Inhale	Guinea Pig	25 ppm / 8H / 46W-I	1. Hepatotoxicity-Hepatolenticular degeneration 2. Kidney, ureter and bladder toxicity-Other changes 3. Endocrine toxicity-Other changes
65	Chronic toxicity	Inhale	Hamster	100 ppm / 12W-I	1. Hepatotoxicity-hepatitis (necrosis of liver cells), spread 2. Hematological toxicity-changes in serum composition (eg TP, bilirubin, cholesterol) 3. Biochemical toxicity-inhibit or induce enzymes
66	Ocular toxicity	Skin surface	rabbit	4 mg	Lighter
67	Ocular toxicity	Skin surface	rabbit	500 mg / 24H	Lighter
68	Ocular toxicity	In the eye	rabbit	2200 ug / 30S	Lighter
69	Ocular toxicity	In the eye	rabbit	500 mg / 24H	Lighter
70	Mutation toxicity		Salmonella typhimurium	20 uL / L
71	Mutation toxicity		E.coli	12500 ng / well
72	Mutation toxicity		E.coli	300 ppm
73	Mutation toxicity		E.coli	200 ug / well
74	Mutation toxicity		Saccharomyces cerevisiae	2 gm / L
75	Mutation toxicity		Aspergillus nidulans	5000 ppm
76	Mutation toxicity		Aspergillus nidulans	5000 ppm
77	Mutation toxicity		Aspergillus nidulans	5000 ppm
78	Mutation toxicity	Intraperitoneal injection	Rat	367 umol / kg
79	Mutation toxicity	Subcutaneous injection	Rat	31 mg / kg / 12W (intermittent)
80	Mutation toxicity		Rat liver	3 mmol / L
81	Mutation toxicity	Intraperitoneal injection	Rat	100 mg / kg
82	Mutation toxicity	Intraperitoneal injection	Rat	100 mg / kg
83	Mutation toxicity	oral	Rat	1400 mg / kg
84	Mutation toxicity	oral	Rat	50 mg / kg
85	Mutation toxicity	Subcutaneous injection	Rat	31 mg / kg / 12W (intermittent)
86	Mutation toxicity	Intraperitoneal injection	Mouse	367 umol / kg
87	Mutation toxicity		Mouse liver	10 umol
88	Mutation toxicity	oral	Mouse	335 umol / kg
89	Mutation toxicity		Mouse lymphocyte	6550 umol / L
90	Mutation toxicity	oral	Mouse	100 mg / kg
91	Mutation toxicity	oral	Mouse	2 mg / kg
92	Mutation toxicity		Hamster fetus	500 ug / L
93	Mutation toxicity		Hamster lung	1600 umol / L
94	Mutation toxicity		Mammalian lymphocyte	1 mmol / L
95	Carcinogenicity	Subcutaneous injection	Rat	15600 mg / kg / 12W-I	1. Carcinogenicity-may be carcinogenic (according to RTECS standards) 2. Liver toxicity-tumor
96	Carcinogenicity	oral	Mouse	4400 mg / kg / 19W-I	1. Carcinogenicity-tumor (according to RTECS standards) 2. Liver toxicity-tumor 3. Skin and accessory toxicity-tumor
97	Carcinogenicity	Parenteral	Mouse	305 mg / kg / 30W-I	1. Carcinogenicity-may be carcinogenic (according to RTECS standards) 2. Liver toxicity-tumor
98	Carcinogenicity	oral	Hamster	9250 mg / kg / 30W-I	1. Carcinogenicity-may be carcinogenic (according to RTECS standards) 2. Hepatotoxicity-hepatitis, fiber (cirrhosis, post-necrotic scar) 3. Liver toxicity-tumor
99	Carcinogenicity	oral	Mouse	12 mg / kg / 88D-I	1. Carcinogenicity-tumor (according to RTECS standards) 2. Liver toxicity-tumor
100	Carcinogenicity	Subcutaneous injection	Rat	100 mg / kg / 25W-I	1. Carcinogenicity-may be carcinogenic (according to RTECS standards) 2. Liver toxicity-tumor
101	Carcinogenicity	Subcutaneous injection	Rat	31 mg / kg / 12W-I	1. Carcinogenicity-may be carcinogenic (according to RTECS standards) 2. Liver toxicity-tumor
102	Carcinogenicity	Subcutaneous injection	Rat	182 mg / kg / 70W-I	1. Carcinogenicity-Carcinogenic (according to RTECS standards) 2. Liver toxicity-tumor 3. Endocrine toxicity-thyroid tumor
103	Carcinogenicity	oral	Mouse	8580 mg / kg / 9W-I	1. Carcinogenicity-tumor (according to RTECS standards) 2. Liver toxicity-tumor
104	Carcinogenicity	oral	Mouse	57600 mg / kg / 12W-I	1. Carcinogenicity-tumor (according to RTECS standards) 2. Liver toxicity-tumor
105	Reproductive toxicity	oral	Rat	2 mg / kg, 7-8 days after conception	1. Reproductive toxicity-increased mortality after implantation
106	Reproductive toxicity	oral	Rat	3 mg / kg, 14 days after female conception	1. Reproductive toxicity-produces additional embryonic structures (eg placenta, umbilical cord)
107	Reproductive toxicity	oral	Rat	150 mg / kg, 8 days after conception	1. Reproductive toxicity-affects the mother 2. Reproductive toxicity-increased mortality after implantation
108	Reproductive toxicity	oral	Rat	750 mg / kg, 6-15 days after conception	1. Reproductive toxicity-increased mortality after implantation
109	Reproductive toxicity	Inhale	Rat	300 ppm / 7H, 6-15 days after conception	1. Reproductive toxicity-fetal toxicity (such as fetal dysplasia but not death) 2. Reproductive toxicity-abnormal development of the musculoskeletal system 3. Reproductive toxicity-abnormal development of the body at steady state
110	Reproductive toxicity	Inhale	Rat	250 ppm / 8H, 10-15 days after conception	1. Reproductive toxicity-affect the vitality index of the newborn (such as alive on the 4th day of birth) 2. Reproductive toxicity-other changes
111	Reproductive toxicity	Intraperitoneal injection	Rat	71500 mg / kg, male mated 15 days ago	1. Reproductive toxicity-changes in testis, epididymis, and vas deferens 2. Reproductive toxicity-changes in prostate, seminal vesicles, Cobb's glands, and accessory glands
112	Reproductive toxicity	Intraperitoneal injection	Rat	5 mg / kg, male mated 1 day ago	1. Reproductive toxicity-affect male fertility
113	Reproductive toxicity	Parenteral	Rat	2384 mg / kg, 18 days after female conception	1. Reproductive toxicity-fetal toxicity (such as fetal dysplasia but not death) 2. Reproductive toxicity-abnormal development of the hepatobiliary system

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