What Is Cycloheximide?

Cycloheximide, another name is actinomycin, a chemical substance, molecular formula: C15H23NO4, molecular weight: 281.35, English name: Cycloheximide.

1. Appearance and properties: off-white to light yellow-brown powder

2. Density: 1.136 g / cm3

3. Melting point: 111-116 ° C

4. Boiling point: 491.8ºC at 760 mmHg

5. Flash point: 251.2ºC

6. Refractive index: 1.498

7. Water solubility: 2.1 g / 100 mL (2 ºC)

8. Stability: Stable. Combustible. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, alkali.

9. Storage conditions: storeroom is ventilated, low-temperature and dry, and stored and transported separately from food ingredients ^[1]

   1. Packing level: II

   2. Hazard category: 6.1 (a)

   3. Customs Code: 29419000

   4. Dangerous Goods Transport Code: UN 2811 6.1 / PG 1

   5. WGK Germany: 3

   6. Danger category code: R28; R51 / 53; R61; R68

   7. Safety instructions: S53-S45-S61

   8. RTECS number: MA4375000

   9. Dangerous goods mark: T +; N

   1. Molar refractive index: 72.66

   2. Molar volume (cm3 / mol): 247.5

   3. Isotonic specific volume (90.2K): 622.4

   4. Surface tension (dyne / cm): 39.9

   5. Polarizability (10-24cm3): 28.80

   1. Hydrophobic parameter calculation reference value (XlogP): None

   2.Number of hydrogen-bonded donors: 2

   3.Number of hydrogen bond acceptors: 4

   4.Number of rotatable chemical bonds: 3

   5.Number of tautomers: 15

   6. Topological molecular polar surface area 83.5

   7.Number of heavy atoms: 20

   8.Surface charge: 0

   9.Complexity: 404

   10.Number of isotope atoms: 0

   11. Determine the number of atomic stereocenters: 4

   12. Uncertain number of atomic stereocenters: 0

   13. Determine the number of chemical bond stereocenters: 0

   14. Uncertain number of chemical bond stereocenters: 0

   15.Number of covalent bond units: 1

   first aid:

   • Inhalation: If inhaled, remove patient to fresh air.

   • Skin contact: Remove contaminated clothing and rinse skin thoroughly with soap and water. Seek medical attention if you feel unwell.

   • Eye contact: Separate the eyelids and rinse with running water or saline. Seek medical attention immediately.

   • Ingestion: Rinse mouth and do not induce vomiting. Seek medical attention immediately.

   Advice for protecting rescuers:

   • Transfer patient to a safe place. Consult a doctor. Show this chemical safety data sheet to the doctor at the scene.

   Extinguishing agent:

   • Extinguish with water spray, dry powder, foam or carbon dioxide.

   • Avoid using DC water to extinguish the fire. DC water may cause the splash of flammable liquid and spread the fire.

   Precautions and protective measures:

   • Firefighters must wear portable breathing apparatus, full-body firefighting suits, and extinguish the fire in the upwind direction.

   • Move the container from the fire to the open space as much as possible.

   • Containers in the fire must be evacuated immediately if they have changed colour or made a sound from a safety pressure relief device.

   • Isolate the scene of the accident and prohibit unrelated personnel from entering. Contain and handle fire fighting water to prevent environmental pollution.

   Worker protective measures, protective equipment and emergency procedures:

   • It is recommended that emergency handlers wear portable breathing apparatus, antistatic clothing, and rubber oil-resistant gloves.

   • Do not touch or cross spillage.

   • All equipment used during work should be grounded.

   • Cut off the source of the leak if possible.

   • Eliminate all ignition sources.

   • The warning area is defined according to the area affected by liquid flow, vapor or dust diffusion, and irrelevant personnel are evacuated from the crosswind and upwind to the safe area.

   Environmental protection measures:

   • Contain spills and avoid polluting the environment. Prevent spills from entering sewers, surface water and groundwater.

   Methods and materials for containment and cleaning up of spilled chemicals:

   • Small leaks: Collect leaking liquid in sealable containers if possible. Absorb with sand, activated carbon or other inert materials and transfer to a safe place. Do not rush into the sewer.

   • Large spills: build dikes or dig pits for containment. Close the drainage pipe. Cover with foam to suppress evaporation. Use explosion-proof pump to transfer to tanker or special collector, recycle or transport to waste disposal place for disposal. ^[2]